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Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy.
Int J Obes (Lond). 2005 Sep; 29(9):1115-20.IJ

Abstract

OBJECTIVE

To evaluate the effect and safety of treatment with low-calorie formula diet on renal function and proteinuria in obese patients with diabetic nephropathy.

DESIGN

Prospective study on safety and efficacy of a 4-week low-calorie (11-19 kcal/kg/day) normal-protein (0.9-1.2 g/kg/day) diet partly supplemented with formula diet.

SUBJECTS

In all, 22 obese patients with diabetic nephropathy (BMI: 30.4+/-5.3 kg/m(2), HbA1c: 7.1+/-1.4%, serum creatinine: 172.4+/-57.5 micromol/l, urinary protein: 3.3+/-2.6 g/day).

RESULTS

The mean body weight decreased by 6.2+/-3.0 kg. The mean systolic blood pressure, creatinine, blood urea nitrogen, urinary protein, and 8-hydroxydeoxyguanosine decreased significantly by 7.5+/-12.7 mmHg, 41.6+/-23.9 micromol/l, 1.50+/-1.61 mmol/l, 1.8+/-1.7 g/day, and 3.1+/-3.6 ng/mg creatinine, respectively. No patient had increased serum creatinine and urinary protein. Mean creatinine clearance (40.6+/-17.9 to 46.1+/-14.6 ml/s/1.73 m(2)) and serum albumin showed no significant changes. Delta serum creatinine and Delta urinary protein correlated with Delta body weight (r=0.62 and 0.49, respectively) and Delta visceral fat area (r=0.58 and 0.58, respectively), but did not correlate with Delta systolic blood pressure, Delta fasting blood glucose and Delta subcutaneous fat area.

CONCLUSION

These results suggested that weight reduction using formula diet might improve renal function and proteinuria safely for a short term in obese patients with diabetic nephropathy.

Authors+Show Affiliations

Saiki A
Center of Diabetes, Endocrine and Metabolism, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan.
Nagayama D
No affiliation info available
Ohhira M
No affiliation info available
Endoh K
No affiliation info available
Ohtsuka M
No affiliation info available
Koide N
No affiliation info available
Oyama T
No affiliation info available
Miyashita Y
No affiliation info available
Shirai K
No affiliation info available

MeSH

Adipose TissueBlood GlucoseBlood PressureCreatinineDiabetic NephropathiesDietary ProteinsEnergy IntakeFemaleFood, FormulatedHumansKidneyMaleMiddle AgedObesityOxidative StressProspective StudiesProteinuriaWeight Loss

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15925953

Citation

Saiki, A, et al. "Effect of Weight Loss Using Formula Diet On Renal Function in Obese Patients With Diabetic Nephropathy." International Journal of Obesity (2005), vol. 29, no. 9, 2005, pp. 1115-20.
Saiki A, Nagayama D, Ohhira M, et al. Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy. Int J Obes (Lond). 2005;29(9):1115-20.
Saiki, A., Nagayama, D., Ohhira, M., Endoh, K., Ohtsuka, M., Koide, N., Oyama, T., Miyashita, Y., & Shirai, K. (2005). Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy. International Journal of Obesity (2005), 29(9), 1115-20.
Saiki A, et al. Effect of Weight Loss Using Formula Diet On Renal Function in Obese Patients With Diabetic Nephropathy. Int J Obes (Lond). 2005;29(9):1115-20. PubMed PMID: 15925953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy. AU - Saiki,A, AU - Nagayama,D, AU - Ohhira,M, AU - Endoh,K, AU - Ohtsuka,M, AU - Koide,N, AU - Oyama,T, AU - Miyashita,Y, AU - Shirai,K, PY - 2005/6/1/pubmed PY - 2006/2/8/medline PY - 2005/6/1/entrez SP - 1115 EP - 20 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 29 IS - 9 N2 - OBJECTIVE: To evaluate the effect and safety of treatment with low-calorie formula diet on renal function and proteinuria in obese patients with diabetic nephropathy. DESIGN: Prospective study on safety and efficacy of a 4-week low-calorie (11-19 kcal/kg/day) normal-protein (0.9-1.2 g/kg/day) diet partly supplemented with formula diet. SUBJECTS: In all, 22 obese patients with diabetic nephropathy (BMI: 30.4+/-5.3 kg/m(2), HbA1c: 7.1+/-1.4%, serum creatinine: 172.4+/-57.5 micromol/l, urinary protein: 3.3+/-2.6 g/day). RESULTS: The mean body weight decreased by 6.2+/-3.0 kg. The mean systolic blood pressure, creatinine, blood urea nitrogen, urinary protein, and 8-hydroxydeoxyguanosine decreased significantly by 7.5+/-12.7 mmHg, 41.6+/-23.9 micromol/l, 1.50+/-1.61 mmol/l, 1.8+/-1.7 g/day, and 3.1+/-3.6 ng/mg creatinine, respectively. No patient had increased serum creatinine and urinary protein. Mean creatinine clearance (40.6+/-17.9 to 46.1+/-14.6 ml/s/1.73 m(2)) and serum albumin showed no significant changes. Delta serum creatinine and Delta urinary protein correlated with Delta body weight (r=0.62 and 0.49, respectively) and Delta visceral fat area (r=0.58 and 0.58, respectively), but did not correlate with Delta systolic blood pressure, Delta fasting blood glucose and Delta subcutaneous fat area. CONCLUSION: These results suggested that weight reduction using formula diet might improve renal function and proteinuria safely for a short term in obese patients with diabetic nephropathy. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/15925953/Effect_of_weight_loss_using_formula_diet_on_renal_function_in_obese_patients_with_diabetic_nephropathy_ DB - PRIME DP - Unbound Medicine ER -