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[Risk factors for Alzheimer's disease].
Rev Neurol 2005 May 16-31; 40(10):613-8RN

Abstract

AIM

In this review we present and discuss the main risk factors for Alzheimer's disease (AD) reported by epidemiological, genetic and biochemical studies.

DEVELOPMENT

The most frequently mentioned factors are: 1. Age. It is the principal marker for the disease risk; 2. Sex. It is estimated that the prevalence of AD is higher in women than in men; 3. Genetics. Although the genetic role has been demonstrated, there is an important genetic heterogeneity; 4. Tobacco. Various studies have found a protective effect, however this effect could be attributed to survival bias; 5. Alcohol. The regular consumption of alcohol was associated with reduced incidence of AD, especially with wine consumption; 6. Family history of dementia. Nearly 40% of persons with AD have family history of dementia; 7. Non steroidal antiinflammatories (NSAIDs). The use of NSAIDS could help in reducing the symptoms of the disease or even avoid them; 8. Craneoencephalic trauma. The role of the craneoencephalic trauma is controversial; 9. Education. The increase of AD in low education persons was published; 10. Diet. The consumption of antioxidants in diet o in supplementary forms appears to be neuroprotector.

CONCLUSIONS

The grand variety of published epidemiological studies with different methodology makes it difficult to find homogeneous results. This leaves us controversial impressions about how to prevent the disease.

Authors+Show Affiliations

Faculty of Medicine, Department of Preventive Medicine and Public Health, Universidad de Córdoba, Av. Menéndez Pidal s/n, E-14004 Córdoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

15926136

Citation

Barranco-Quintana, J L., et al. "[Risk Factors for Alzheimer's Disease]." Revista De Neurologia, vol. 40, no. 10, 2005, pp. 613-8.
Barranco-Quintana JL, Allam MF, Del Castillo AS, et al. [Risk factors for Alzheimer's disease]. Rev Neurol. 2005;40(10):613-8.
Barranco-Quintana, J. L., Allam, M. F., Del Castillo, A. S., & Navajas, R. F. (2005). [Risk factors for Alzheimer's disease]. Revista De Neurologia, 40(10), pp. 613-8.
Barranco-Quintana JL, et al. [Risk Factors for Alzheimer's Disease]. Rev Neurol. 2005;40(10):613-8. PubMed PMID: 15926136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Risk factors for Alzheimer's disease]. AU - Barranco-Quintana,J L, AU - Allam,M F, AU - Del Castillo,A S, AU - Navajas,R F-C, PY - 2005/6/1/pubmed PY - 2005/9/16/medline PY - 2005/6/1/entrez SP - 613 EP - 8 JF - Revista de neurologia JO - Rev Neurol VL - 40 IS - 10 N2 - AIM: In this review we present and discuss the main risk factors for Alzheimer's disease (AD) reported by epidemiological, genetic and biochemical studies. DEVELOPMENT: The most frequently mentioned factors are: 1. Age. It is the principal marker for the disease risk; 2. Sex. It is estimated that the prevalence of AD is higher in women than in men; 3. Genetics. Although the genetic role has been demonstrated, there is an important genetic heterogeneity; 4. Tobacco. Various studies have found a protective effect, however this effect could be attributed to survival bias; 5. Alcohol. The regular consumption of alcohol was associated with reduced incidence of AD, especially with wine consumption; 6. Family history of dementia. Nearly 40% of persons with AD have family history of dementia; 7. Non steroidal antiinflammatories (NSAIDs). The use of NSAIDS could help in reducing the symptoms of the disease or even avoid them; 8. Craneoencephalic trauma. The role of the craneoencephalic trauma is controversial; 9. Education. The increase of AD in low education persons was published; 10. Diet. The consumption of antioxidants in diet o in supplementary forms appears to be neuroprotector. CONCLUSIONS: The grand variety of published epidemiological studies with different methodology makes it difficult to find homogeneous results. This leaves us controversial impressions about how to prevent the disease. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/15926136/[Risk_factors_for_Alzheimer's_disease]_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2004360&Revista=RevNeurol DB - PRIME DP - Unbound Medicine ER -