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[Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides].
Izv Akad Nauk Ser Biol. 2001 Sep-OctIA

Abstract

In our study of the effect of proline-containing linear di- and tri-peptides (Pro-Gly, Pro-Gly-Pro) and cyclic peptide cPro-Gly in vitro, we have found that they show depolymerizing activity towards the nonstabilized form of fibrin in the presence and in the absence of sigma-aminocapronic acid, an inhibitor of enzymatic fibrinolysis. The peptides have an inhibitory effect on platelet aggregation in platelet-enriched blood plasma, when the process is induced by ADP, they also diminish the activity of factor XIIIa in blood plasma.

Authors

Pastorova VE
No affiliation info available
Liapina LA
No affiliation info available
Alshmarin IP
No affiliation info available
Ostrovskaia PU
No affiliation info available
Gudasheva TA
No affiliation info available
Lugovskoĭ EV
No affiliation info available

MeSH

AnimalsBlood PlateletsDipeptidesFibrinFibrinolytic AgentsOligopeptidesPeptides, CyclicPlatelet AggregationPlatelet Aggregation InhibitorsProlineRats

Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

15926323

Citation

Pastorova, V E., et al. "[Fibrin-depolymerization Activity and the Antiplatelet Effect of Small Cyclic and Linear Proline-containing Peptides]." Izvestiia Akademii Nauk. Seriia Biologicheskaia, 2001, pp. 593-6.
Pastorova VE, Liapina LA, Alshmarin IP, et al. [Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides]. Izv Akad Nauk Ser Biol. 2001.
Pastorova, V. E., Liapina, L. A., Alshmarin, I. P., Ostrovskaia, P. U., Gudasheva, T. A., & Lugovskoĭ, E. V. (2001). [Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides]. Izvestiia Akademii Nauk. Seriia Biologicheskaia, (5), 593-6.
Pastorova VE, et al. [Fibrin-depolymerization Activity and the Antiplatelet Effect of Small Cyclic and Linear Proline-containing Peptides]. Izv Akad Nauk Ser Biol. 2001 Sep-Oct;(5)593-6. PubMed PMID: 15926323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides]. AU - Pastorova,V E, AU - Liapina,L A, AU - Alshmarin,I P, AU - Ostrovskaia,P U, AU - Gudasheva,T A, AU - Lugovskoĭ,E V, PY - 2005/6/2/pubmed PY - 2005/7/26/medline PY - 2005/6/2/entrez SP - 593 EP - 6 JF - Izvestiia Akademii nauk. Seriia biologicheskaia JO - Izv Akad Nauk Ser Biol IS - 5 N2 - In our study of the effect of proline-containing linear di- and tri-peptides (Pro-Gly, Pro-Gly-Pro) and cyclic peptide cPro-Gly in vitro, we have found that they show depolymerizing activity towards the nonstabilized form of fibrin in the presence and in the absence of sigma-aminocapronic acid, an inhibitor of enzymatic fibrinolysis. The peptides have an inhibitory effect on platelet aggregation in platelet-enriched blood plasma, when the process is induced by ADP, they also diminish the activity of factor XIIIa in blood plasma. SN - 1026-3470 UR - https://www.unboundmedicine.com/medline/citation/15926323/[Fibrin_depolymerization_activity_and_the_antiplatelet_effect_of_small_cyclic_and_linear_proline_containing_peptides]_ DB - PRIME DP - Unbound Medicine ER -