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Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis.
Cytokine. 2005 Jun 07; 30(5):243-7.C

Abstract

BACKGROUND

It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus.

METHODS

We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM).

RESULTS

The CSF IFN-gamma, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-gamma, IL-2, and IL-6 levels were elevated in EM. The CSF IFN-gamma, IL-2, and IL-10 levels in MM were significantly higher than those in EM (p<0.0001, p<0.0001, and p<0.0001, respectively). The CSF IL-6 levels in EM were significantly higher than those in MM (p=0.0255). The CSF TNF-alpha and IL-4 levels were not elevated in MM or EM. In MM, the IL-6 level was correlated with the IL-2 and IL-10 levels in CSF (p=0.0347 and p=0.0120, respectively). In EM, the IFN-gamma level was correlated with the IL-10 level in CSF (p=0.0002).

CONCLUSION

CSF cytokine profiles in MM were different from those in EM. Therefore, it is likely that the pathogenesis of MM is different from that of EM.

Authors+Show Affiliations

Department of Pediatrics, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ichiyama@yamaguchi-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15927848

Citation

Ichiyama, Takashi, et al. "Analysis of Cytokine Levels in Cerebrospinal Fluid in Mumps Meningitis: Comparison With Echovirus Type 30 Meningitis." Cytokine, vol. 30, no. 5, 2005, pp. 243-7.
Ichiyama T, Maeba S, Suenaga N, et al. Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis. Cytokine. 2005;30(5):243-7.
Ichiyama, T., Maeba, S., Suenaga, N., Saito, K., Matsubara, T., & Furukawa, S. (2005). Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis. Cytokine, 30(5), 243-7.
Ichiyama T, et al. Analysis of Cytokine Levels in Cerebrospinal Fluid in Mumps Meningitis: Comparison With Echovirus Type 30 Meningitis. Cytokine. 2005 Jun 7;30(5):243-7. PubMed PMID: 15927848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis. AU - Ichiyama,Takashi, AU - Maeba,Shinji, AU - Suenaga,Naoko, AU - Saito,Kumiko, AU - Matsubara,Tomoyo, AU - Furukawa,Susumu, Y1 - 2005/03/23/ PY - 2004/09/21/received PY - 2004/10/27/revised PY - 2005/01/08/accepted PY - 2005/6/2/pubmed PY - 2005/11/16/medline PY - 2005/6/2/entrez SP - 243 EP - 7 JF - Cytokine JO - Cytokine VL - 30 IS - 5 N2 - BACKGROUND: It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus. METHODS: We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM). RESULTS: The CSF IFN-gamma, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-gamma, IL-2, and IL-6 levels were elevated in EM. The CSF IFN-gamma, IL-2, and IL-10 levels in MM were significantly higher than those in EM (p<0.0001, p<0.0001, and p<0.0001, respectively). The CSF IL-6 levels in EM were significantly higher than those in MM (p=0.0255). The CSF TNF-alpha and IL-4 levels were not elevated in MM or EM. In MM, the IL-6 level was correlated with the IL-2 and IL-10 levels in CSF (p=0.0347 and p=0.0120, respectively). In EM, the IFN-gamma level was correlated with the IL-10 level in CSF (p=0.0002). CONCLUSION: CSF cytokine profiles in MM were different from those in EM. Therefore, it is likely that the pathogenesis of MM is different from that of EM. SN - 1043-4666 UR - https://www.unboundmedicine.com/medline/citation/15927848/Analysis_of_cytokine_levels_in_cerebrospinal_fluid_in_mumps_meningitis:_comparison_with_echovirus_type_30_meningitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(05)00065-7 DB - PRIME DP - Unbound Medicine ER -