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Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age.
Asia Pac J Clin Nutr. 2005; 14(2):173-8.AP

Abstract

Daily consumption of 400 microg folic acid prior to conception and during early pregnancy is recommended for the prevention of neural tube defects (NTD). Strategies to increase folic acid consumption include supplements and fortified foods. Milk is consumed by women and can be fortified with folic acid but little is known about the effect of fortified milk on blood folate concentration in women of childbearing age. The objective of this study was to determine whether daily consumption of milk fortified with 375 microg folic acid increases blood folate and lowers homocysteine concentrations in women of childbearing age. Seventy-three non-pregnant women (aged 18-47 y) were randomized to receive either 75 g/d of a fortified or unfortified (control) milk powder for 12 weeks. Women who consumed the folic acid fortified milk had mean (95% CI) red blood cell and plasma folate concentrations that were 539 nmol/L (436, 641) and 35 nmol/L (30, 41) higher, respectively, than in the control group. Women drinking fortified milk had a 14% lower mean plasma homocysteine concentration at week 12 than women consuming the control milk. Daily consumption of fortified milk powder providing 375 microg folic acid increases blood folate and lowers homocysteine concentrations over 12 weeks in women of childbearing age. Daily consumption of fortified milk would be expected to reduce NTD risk.

Authors+Show Affiliations

Green TJ
Department of Human Nutrition, University of Otago, Dunedin, New Zealand. tim.green@stonebow.otago.ac.nz
Skeaff CM
No affiliation info available
Rockell JE
No affiliation info available
Venn BJ
No affiliation info available

MeSH

AdolescentAdultAnimalsBiological AvailabilityDouble-Blind MethodErythrocytesFemaleFolic AcidFood, FortifiedHomocysteineHumansMiddle AgedMilkNeural Tube DefectsNutritional Status

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15927936

Citation

Green, Timothy J., et al. "Folic Acid Fortified Milk Increases Blood Folate and Lowers Homocysteine Concentration in Women of Childbearing Age." Asia Pacific Journal of Clinical Nutrition, vol. 14, no. 2, 2005, pp. 173-8.
Green TJ, Skeaff CM, Rockell JE, et al. Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age. Asia Pac J Clin Nutr. 2005;14(2):173-8.
Green, T. J., Skeaff, C. M., Rockell, J. E., & Venn, B. J. (2005). Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age. Asia Pacific Journal of Clinical Nutrition, 14(2), 173-8.
Green TJ, et al. Folic Acid Fortified Milk Increases Blood Folate and Lowers Homocysteine Concentration in Women of Childbearing Age. Asia Pac J Clin Nutr. 2005;14(2):173-8. PubMed PMID: 15927936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age. AU - Green,Timothy J, AU - Skeaff,C Murray, AU - Rockell,Jennifer E P, AU - Venn,Bernard J, PY - 2005/6/2/pubmed PY - 2005/9/9/medline PY - 2005/6/2/entrez SP - 173 EP - 8 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 14 IS - 2 N2 - Daily consumption of 400 microg folic acid prior to conception and during early pregnancy is recommended for the prevention of neural tube defects (NTD). Strategies to increase folic acid consumption include supplements and fortified foods. Milk is consumed by women and can be fortified with folic acid but little is known about the effect of fortified milk on blood folate concentration in women of childbearing age. The objective of this study was to determine whether daily consumption of milk fortified with 375 microg folic acid increases blood folate and lowers homocysteine concentrations in women of childbearing age. Seventy-three non-pregnant women (aged 18-47 y) were randomized to receive either 75 g/d of a fortified or unfortified (control) milk powder for 12 weeks. Women who consumed the folic acid fortified milk had mean (95% CI) red blood cell and plasma folate concentrations that were 539 nmol/L (436, 641) and 35 nmol/L (30, 41) higher, respectively, than in the control group. Women drinking fortified milk had a 14% lower mean plasma homocysteine concentration at week 12 than women consuming the control milk. Daily consumption of fortified milk powder providing 375 microg folic acid increases blood folate and lowers homocysteine concentrations over 12 weeks in women of childbearing age. Daily consumption of fortified milk would be expected to reduce NTD risk. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/15927936/Folic_acid_fortified_milk_increases_blood_folate_and_lowers_homocysteine_concentration_in_women_of_childbearing_age_ DB - PRIME DP - Unbound Medicine ER -