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Slowing progression along the renal disease continuum.
J Am Osteopath Assoc. 2005 Apr; 105(4):207-15.JA

Abstract

Patients in whom nephropathy develops as a result of hypertension or diabetes mellitus are more likely to die of cardiovascular disease (CVD) than of kidney disease. An early sign of impending nephropathy is microalbuminuria, defined as urinary excretion of albumin at a rate of 28.8 mg/24 h to 288 mg/24 h. Microalbuminuria is a marker of endothelial dysfunction, vascular injury, and renal disease and CVD, and it is associated with increased risk for myocardial infarction. Oxidative stress and endothelial dysfunction are unifying factors mediated by the renin-angiotensin system in renal disease and CVD. Clinical trials show reduced cardiovascular risk and a reversal of microalbuminuria with the use of agents that affect the renin-angiotensin system: angiotensin-receptor blockers in patients with type 2 diabetes mellitus and nephropathy, or angiotensin-converting enzyme inhibitors in patients with type 1 diabetes mellitus.

Authors+Show Affiliations

Temle University, Philadelphia, PA, USA. DrNPK@aol.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15928338

Citation

Kopyt, Nelson P.. "Slowing Progression Along the Renal Disease Continuum." The Journal of the American Osteopathic Association, vol. 105, no. 4, 2005, pp. 207-15.
Kopyt NP. Slowing progression along the renal disease continuum. J Am Osteopath Assoc. 2005;105(4):207-15.
Kopyt, N. P. (2005). Slowing progression along the renal disease continuum. The Journal of the American Osteopathic Association, 105(4), 207-15.
Kopyt NP. Slowing Progression Along the Renal Disease Continuum. J Am Osteopath Assoc. 2005;105(4):207-15. PubMed PMID: 15928338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Slowing progression along the renal disease continuum. A1 - Kopyt,Nelson P, PY - 2005/6/2/pubmed PY - 2005/9/28/medline PY - 2005/6/2/entrez SP - 207 EP - 15 JF - The Journal of the American Osteopathic Association JO - J Am Osteopath Assoc VL - 105 IS - 4 N2 - Patients in whom nephropathy develops as a result of hypertension or diabetes mellitus are more likely to die of cardiovascular disease (CVD) than of kidney disease. An early sign of impending nephropathy is microalbuminuria, defined as urinary excretion of albumin at a rate of 28.8 mg/24 h to 288 mg/24 h. Microalbuminuria is a marker of endothelial dysfunction, vascular injury, and renal disease and CVD, and it is associated with increased risk for myocardial infarction. Oxidative stress and endothelial dysfunction are unifying factors mediated by the renin-angiotensin system in renal disease and CVD. Clinical trials show reduced cardiovascular risk and a reversal of microalbuminuria with the use of agents that affect the renin-angiotensin system: angiotensin-receptor blockers in patients with type 2 diabetes mellitus and nephropathy, or angiotensin-converting enzyme inhibitors in patients with type 1 diabetes mellitus. SN - 0098-6151 UR - https://www.unboundmedicine.com/medline/citation/15928338/Slowing_progression_along_the_renal_disease_continuum_ L2 - http://jaoa.org/article.aspx?volume=105&page=207 DB - PRIME DP - Unbound Medicine ER -