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Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans.
Eur J Clin Nutr. 2005 Aug; 59(8):906-13.EJ

Abstract

OBJECTIVE

The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is (partly) denatured in ultra-high-temperature (UHT)-treated milk. The effect of FBP on folate bioavailability is still unclear.

DESIGN, SUBJECTS AND SETTING

Healthy, free-living subjects (n=69) aged 18-49 y participated in a 4-week double-blind, placebo-controlled dietary intervention study.

INTERVENTION

In addition to a fully controlled diet, the subjects consumed each day 500 ml of pasteurised or UHT milk, either fortified or not with 200 mug folic acid.

RESULTS

Consumption of fortified milk increased folate concentrations in serum and in red blood cells (RBC) by 6.6-7.0 nmol/l (P<0.001) and 32-36 nmol/l (P<0.01), respectively. Similarly, plasma homocysteine concentrations were lowered 0.88-0.89 micromol/l (P=0.001) in subjects who consumed fortified milk. The bioavailability of folic acid from pasteurised milk relative to that of folic acid from UHT milk was 74-94% (NS), depending on the parameter used.

CONCLUSIONS

Milk fortified to supply an additional 200 microg of folic acid/s substantially increased folate status, and decreased plasma total homocysteine concentrations in young, healthy subjects. Milk is therefore a suitable matrix for fortification to enhance the folate status in humans. No significant effect of endogenous FBP was found on the bioavailability of folic acid from milk.

Authors+Show Affiliations

TNO-WU Centre for Micronutrient Research, Zeist and Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15928685

Citation

de Jong, R J., et al. "Bioavailability of Folic Acid From Fortified Pasteurised and UHT-treated Milk in Humans." European Journal of Clinical Nutrition, vol. 59, no. 8, 2005, pp. 906-13.
de Jong RJ, Verwei M, West CE, et al. Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans. Eur J Clin Nutr. 2005;59(8):906-13.
de Jong, R. J., Verwei, M., West, C. E., van Vliet, T., Siebelink, E., van den Berg, H., & Castenmiller, J. J. (2005). Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans. European Journal of Clinical Nutrition, 59(8), 906-13.
de Jong RJ, et al. Bioavailability of Folic Acid From Fortified Pasteurised and UHT-treated Milk in Humans. Eur J Clin Nutr. 2005;59(8):906-13. PubMed PMID: 15928685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans. AU - de Jong,R J, AU - Verwei,M, AU - West,C E, AU - van Vliet,T, AU - Siebelink,E, AU - van den Berg,H, AU - Castenmiller,J J M, PY - 2005/6/2/pubmed PY - 2005/10/21/medline PY - 2005/6/2/entrez SP - 906 EP - 13 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 8 N2 - OBJECTIVE: The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is (partly) denatured in ultra-high-temperature (UHT)-treated milk. The effect of FBP on folate bioavailability is still unclear. DESIGN, SUBJECTS AND SETTING: Healthy, free-living subjects (n=69) aged 18-49 y participated in a 4-week double-blind, placebo-controlled dietary intervention study. INTERVENTION: In addition to a fully controlled diet, the subjects consumed each day 500 ml of pasteurised or UHT milk, either fortified or not with 200 mug folic acid. RESULTS: Consumption of fortified milk increased folate concentrations in serum and in red blood cells (RBC) by 6.6-7.0 nmol/l (P<0.001) and 32-36 nmol/l (P<0.01), respectively. Similarly, plasma homocysteine concentrations were lowered 0.88-0.89 micromol/l (P=0.001) in subjects who consumed fortified milk. The bioavailability of folic acid from pasteurised milk relative to that of folic acid from UHT milk was 74-94% (NS), depending on the parameter used. CONCLUSIONS: Milk fortified to supply an additional 200 microg of folic acid/s substantially increased folate status, and decreased plasma total homocysteine concentrations in young, healthy subjects. Milk is therefore a suitable matrix for fortification to enhance the folate status in humans. No significant effect of endogenous FBP was found on the bioavailability of folic acid from milk. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15928685/Bioavailability_of_folic_acid_from_fortified_pasteurised_and_UHT_treated_milk_in_humans_ L2 - https://doi.org/10.1038/sj.ejcn.1602159 DB - PRIME DP - Unbound Medicine ER -