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Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study.
Int J Cancer 2005; 117(4):643-7IJ

Abstract

We examined associations among dietary heme iron as a possible pro-oxidant, dietary zinc as a possible antioxidant, and the incidence of upper digestive tract cancer; 34,708 postmenopausal women, aged 55-69 years at baseline who completed a food frequency questionnaire, were followed 16 years. There were 75 upper digestive tract cancer cases (52 gastric cancer and 23 esophageal cancer). When heme iron and zinc were mutually adjusted, in dose-response manners, heme iron intake was positively associated with the risk of upper digestive tract cancer, while zinc intake was inversely associated with risk. After adjusting for age, total energy intake, cigarette smoking and alcohol consumption, relative risks for quintiles of heme iron intake were 1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and corresponding relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13 (p for trend < 0.01). Additional adjustment for body mass index, physical activity, hormone replacement therapy, multivitamin intake and intake of saturated fat, vitamin C, vitamin E and folate did not change the results. Higher intake of heme iron is associated with higher risk, while higher intake of zinc is associated with lower, risk of upper digestive tract cancer.

Authors+Show Affiliations

Department of Preventive Medicine, College of Medicine, Kyungpook National University, Daegu, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15929082

Citation

Lee, Duk-Hee, et al. "Heme Iron, Zinc and Upper Digestive Tract Cancer: the Iowa Women's Health Study." International Journal of Cancer, vol. 117, no. 4, 2005, pp. 643-7.
Lee DH, Anderson KE, Folsom AR, et al. Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study. Int J Cancer. 2005;117(4):643-7.
Lee, D. H., Anderson, K. E., Folsom, A. R., & Jacobs, D. R. (2005). Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study. International Journal of Cancer, 117(4), pp. 643-7.
Lee DH, et al. Heme Iron, Zinc and Upper Digestive Tract Cancer: the Iowa Women's Health Study. Int J Cancer. 2005 Nov 20;117(4):643-7. PubMed PMID: 15929082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study. AU - Lee,Duk-Hee, AU - Anderson,Kristin E, AU - Folsom,Aaron R, AU - Jacobs,David R,Jr PY - 2005/6/2/pubmed PY - 2005/11/16/medline PY - 2005/6/2/entrez SP - 643 EP - 7 JF - International journal of cancer JO - Int. J. Cancer VL - 117 IS - 4 N2 - We examined associations among dietary heme iron as a possible pro-oxidant, dietary zinc as a possible antioxidant, and the incidence of upper digestive tract cancer; 34,708 postmenopausal women, aged 55-69 years at baseline who completed a food frequency questionnaire, were followed 16 years. There were 75 upper digestive tract cancer cases (52 gastric cancer and 23 esophageal cancer). When heme iron and zinc were mutually adjusted, in dose-response manners, heme iron intake was positively associated with the risk of upper digestive tract cancer, while zinc intake was inversely associated with risk. After adjusting for age, total energy intake, cigarette smoking and alcohol consumption, relative risks for quintiles of heme iron intake were 1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and corresponding relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13 (p for trend < 0.01). Additional adjustment for body mass index, physical activity, hormone replacement therapy, multivitamin intake and intake of saturated fat, vitamin C, vitamin E and folate did not change the results. Higher intake of heme iron is associated with higher risk, while higher intake of zinc is associated with lower, risk of upper digestive tract cancer. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15929082/Heme_iron_zinc_and_upper_digestive_tract_cancer:_the_Iowa_Women's_Health_Study_ L2 - https://doi.org/10.1002/ijc.21215 DB - PRIME DP - Unbound Medicine ER -