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Vegetable and fruit consumption and risk of renal cell carcinoma: results from the Netherlands cohort study.
Int J Cancer 2005; 117(4):648-54IJ

Abstract

Vegetable and fruit consumption is generally inversely associated with various cancer types, including renal cell carcinoma (RCC). The Netherlands cohort study on diet and cancer (NLCS) consists of 120,852 men and women, aged 55-69 years, who filled out a self-administered questionnaire that includes 150-item food-frequency questions and additional questions on lifestyle factors, at baseline in 1986. A case-cohort approach was used. After 9.3 years of follow-up, 275 microscopically confirmed incident cases were identified. Subjects with incomplete or inconsistent dietary data were excluded, leaving 260 RCC cases for analyses on fruit consumption and 249 RCC cases for analyses on vegetable consumption. Incidence rate ratios (RR) and corresponding 95% confidence intervals (CI) were estimated using Cox proportional hazard models. RRs for exposure variables are expressed per increment of 25 g/day and are adjusted for age, sex, smoking, body mass index and history of hypertension at baseline. The RRs for vegetable consumption were further adjusted for fruit consumption and vice versa. Total vegetable and fruit consumption (RR: 1.00; 95% CI 0.97-1.02), vegetable (RR: 1.00, 95% CI 0.96-1.06) and fruit consumption (RR: 1.00; 95% CI 0.97-1.03) were not associated with RCC risk. Also, no association existed for botanical subgroups of vegetables and fruit. For 30 individual vegetables and fruits, we observed one that significantly increased RR (mandarin consumption, RR: 1.76; 95% CI 1.28-2.42), which must be regarded cautiously because of multiple testing. These results suggest the absence of an association between vegetable and/or fruit consumption and RCC risk.

Authors+Show Affiliations

Department of Epidemiology, NUTRIM, Maastricht University, the Netherlands. Boukje.vanDijk@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15929109

Citation

van Dijk, Boukje A C., et al. "Vegetable and Fruit Consumption and Risk of Renal Cell Carcinoma: Results From the Netherlands Cohort Study." International Journal of Cancer, vol. 117, no. 4, 2005, pp. 648-54.
van Dijk BA, Schouten LJ, Kiemeney LA, et al. Vegetable and fruit consumption and risk of renal cell carcinoma: results from the Netherlands cohort study. Int J Cancer. 2005;117(4):648-54.
van Dijk, B. A., Schouten, L. J., Kiemeney, L. A., Goldbohm, R. A., & van den Brandt, P. A. (2005). Vegetable and fruit consumption and risk of renal cell carcinoma: results from the Netherlands cohort study. International Journal of Cancer, 117(4), pp. 648-54.
van Dijk BA, et al. Vegetable and Fruit Consumption and Risk of Renal Cell Carcinoma: Results From the Netherlands Cohort Study. Int J Cancer. 2005 Nov 20;117(4):648-54. PubMed PMID: 15929109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetable and fruit consumption and risk of renal cell carcinoma: results from the Netherlands cohort study. AU - van Dijk,Boukje A C, AU - Schouten,Leo J, AU - Kiemeney,Lambertus A L M, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, PY - 2005/6/2/pubmed PY - 2005/11/16/medline PY - 2005/6/2/entrez SP - 648 EP - 54 JF - International journal of cancer JO - Int. J. Cancer VL - 117 IS - 4 N2 - Vegetable and fruit consumption is generally inversely associated with various cancer types, including renal cell carcinoma (RCC). The Netherlands cohort study on diet and cancer (NLCS) consists of 120,852 men and women, aged 55-69 years, who filled out a self-administered questionnaire that includes 150-item food-frequency questions and additional questions on lifestyle factors, at baseline in 1986. A case-cohort approach was used. After 9.3 years of follow-up, 275 microscopically confirmed incident cases were identified. Subjects with incomplete or inconsistent dietary data were excluded, leaving 260 RCC cases for analyses on fruit consumption and 249 RCC cases for analyses on vegetable consumption. Incidence rate ratios (RR) and corresponding 95% confidence intervals (CI) were estimated using Cox proportional hazard models. RRs for exposure variables are expressed per increment of 25 g/day and are adjusted for age, sex, smoking, body mass index and history of hypertension at baseline. The RRs for vegetable consumption were further adjusted for fruit consumption and vice versa. Total vegetable and fruit consumption (RR: 1.00; 95% CI 0.97-1.02), vegetable (RR: 1.00, 95% CI 0.96-1.06) and fruit consumption (RR: 1.00; 95% CI 0.97-1.03) were not associated with RCC risk. Also, no association existed for botanical subgroups of vegetables and fruit. For 30 individual vegetables and fruits, we observed one that significantly increased RR (mandarin consumption, RR: 1.76; 95% CI 1.28-2.42), which must be regarded cautiously because of multiple testing. These results suggest the absence of an association between vegetable and/or fruit consumption and RCC risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15929109/Vegetable_and_fruit_consumption_and_risk_of_renal_cell_carcinoma:_results_from_the_Netherlands_cohort_study_ L2 - https://doi.org/10.1002/ijc.21203 DB - PRIME DP - Unbound Medicine ER -