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Intracranial Ewing sarcoma.
Pediatr Blood Cancer. 2005 Nov; 45(6):850-6.PB

Abstract

The occurrence of primary extraosseous Ewing sarcoma (EES) of the central nervous system (CNS) has only rarely been reported in the literature. It is important to distinguish this entity from the more common central primitive neuroectodermal tumor (PNET) of brain, since the management of these tumors is different from that of EES. We present the clinical, radiologic, and pathologic features of two cases of EES occurring in the brain. The diagnosis was further confirmed by detection of a rearrangement of the FLI1 and/or EWS gene loci in tumors from both patients using fluorescent in situ hybridization (FISH). Although rare, the possibility of EES should be considered particularly when tumors that arise near the meningeal surface of the brain and have the pathologic appearance of a PNET. Demonstration of t(11;22)(q24;q12) by molecular analysis essentially confirms the diagnosis and enables the oncologist to choose appropriate therapy.

Authors+Show Affiliations

Department of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15929128

Citation

Mazur, Melissa A., et al. "Intracranial Ewing Sarcoma." Pediatric Blood & Cancer, vol. 45, no. 6, 2005, pp. 850-6.
Mazur MA, Gururangan S, Bridge JA, et al. Intracranial Ewing sarcoma. Pediatr Blood Cancer. 2005;45(6):850-6.
Mazur, M. A., Gururangan, S., Bridge, J. A., Cummings, T. J., Mukundan, S., Fuchs, H., Larrier, N., & Halperin, E. C. (2005). Intracranial Ewing sarcoma. Pediatric Blood & Cancer, 45(6), 850-6.
Mazur MA, et al. Intracranial Ewing Sarcoma. Pediatr Blood Cancer. 2005;45(6):850-6. PubMed PMID: 15929128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracranial Ewing sarcoma. AU - Mazur,Melissa A, AU - Gururangan,Sridharan, AU - Bridge,Julia A, AU - Cummings,Thomas J, AU - Mukundan,Srinivasan, AU - Fuchs,Herbert, AU - Larrier,Nicole, AU - Halperin,Edward C, PY - 2005/6/2/pubmed PY - 2005/12/29/medline PY - 2005/6/2/entrez SP - 850 EP - 6 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 45 IS - 6 N2 - The occurrence of primary extraosseous Ewing sarcoma (EES) of the central nervous system (CNS) has only rarely been reported in the literature. It is important to distinguish this entity from the more common central primitive neuroectodermal tumor (PNET) of brain, since the management of these tumors is different from that of EES. We present the clinical, radiologic, and pathologic features of two cases of EES occurring in the brain. The diagnosis was further confirmed by detection of a rearrangement of the FLI1 and/or EWS gene loci in tumors from both patients using fluorescent in situ hybridization (FISH). Although rare, the possibility of EES should be considered particularly when tumors that arise near the meningeal surface of the brain and have the pathologic appearance of a PNET. Demonstration of t(11;22)(q24;q12) by molecular analysis essentially confirms the diagnosis and enables the oncologist to choose appropriate therapy. SN - 1545-5009 UR - https://www.unboundmedicine.com/medline/citation/15929128/Intracranial_Ewing_sarcoma_ L2 - https://doi.org/10.1002/pbc.20430 DB - PRIME DP - Unbound Medicine ER -