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Obesity is an independent risk factor for GERD symptoms and erosive esophagitis.
Am J Gastroenterol. 2005 Jun; 100(6):1243-50.AJ

Abstract

INTRODUCTION

An association between obesity and GERD symptoms has been reported; however, study results have been inconsistent and it is not known whether an association persists after adjusting for other known GERD risk factors.

METHODS

We carried out a cross-sectional study to determine the prevalence and risk factors of GERD in volunteers (VA employees). Participants completed a Gastroesophageal Reflux Questionnaire, the Block 98 Food Frequency Questionnaire, provided height and weight information, and were invited for upper endoscopy with biopsies. Associations of body mass index (BMI) with GERD symptoms and erosive esophagitis were examined separately in multiple logistic regression analyses adjusting for age, sex, race, GERD symptoms, dietary intake, education level, family history of GERD, H. pylori infection, and the presence and distribution of gastritis.

RESULTS

Four hundred and fifty-three persons (mean age 44 yr, 70% women and 43% black) provided complete information on heartburn, regurgitation, and BMI (50% of 915 who received questionnaires). Of the 196 who underwent endoscopy, 44 (22%) had esophageal erosions and 118 (26%) reported at least weekly heartburn or regurgitation. A dose-response relationship between frequency of heartburn or regurgitation and higher BMI was observed. Compared to participants without weekly symptoms, a significantly larger proportion of the 118 with these symptoms were either overweight (BMI 25-30) (35% vs 32%) or obese (BMI>30) (39% vs 26%), p for linear trend 0.004. Relative to those with no esophageal erosions, those with erosions were more likely to be overweight (39%vs 26%) or obese (41% vs 32%), p=0.04. Obese participants were 2.5 times as likely as those with normal BMI (<25) to have reflux symptoms or esophageal erosions. The association between BMI and GERD symptoms persisted in direction and magnitude after adjustment for potential confounders.

CONCLUSIONS

Overweight and obesity are strong independent risk factor of GERD symptoms and esophageal erosions. The amount or composition of dietary intake does not appear to be a likely explanation for these findings.

Authors+Show Affiliations

Section of Gastroenterology at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15929752

Citation

El-Serag, Hashem B., et al. "Obesity Is an Independent Risk Factor for GERD Symptoms and Erosive Esophagitis." The American Journal of Gastroenterology, vol. 100, no. 6, 2005, pp. 1243-50.
El-Serag HB, Graham DY, Satia JA, et al. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol. 2005;100(6):1243-50.
El-Serag, H. B., Graham, D. Y., Satia, J. A., & Rabeneck, L. (2005). Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. The American Journal of Gastroenterology, 100(6), 1243-50.
El-Serag HB, et al. Obesity Is an Independent Risk Factor for GERD Symptoms and Erosive Esophagitis. Am J Gastroenterol. 2005;100(6):1243-50. PubMed PMID: 15929752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. AU - El-Serag,Hashem B, AU - Graham,David Y, AU - Satia,Jessie A, AU - Rabeneck,Linda, PY - 2005/6/3/pubmed PY - 2005/8/10/medline PY - 2005/6/3/entrez SP - 1243 EP - 50 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 100 IS - 6 N2 - INTRODUCTION: An association between obesity and GERD symptoms has been reported; however, study results have been inconsistent and it is not known whether an association persists after adjusting for other known GERD risk factors. METHODS: We carried out a cross-sectional study to determine the prevalence and risk factors of GERD in volunteers (VA employees). Participants completed a Gastroesophageal Reflux Questionnaire, the Block 98 Food Frequency Questionnaire, provided height and weight information, and were invited for upper endoscopy with biopsies. Associations of body mass index (BMI) with GERD symptoms and erosive esophagitis were examined separately in multiple logistic regression analyses adjusting for age, sex, race, GERD symptoms, dietary intake, education level, family history of GERD, H. pylori infection, and the presence and distribution of gastritis. RESULTS: Four hundred and fifty-three persons (mean age 44 yr, 70% women and 43% black) provided complete information on heartburn, regurgitation, and BMI (50% of 915 who received questionnaires). Of the 196 who underwent endoscopy, 44 (22%) had esophageal erosions and 118 (26%) reported at least weekly heartburn or regurgitation. A dose-response relationship between frequency of heartburn or regurgitation and higher BMI was observed. Compared to participants without weekly symptoms, a significantly larger proportion of the 118 with these symptoms were either overweight (BMI 25-30) (35% vs 32%) or obese (BMI>30) (39% vs 26%), p for linear trend 0.004. Relative to those with no esophageal erosions, those with erosions were more likely to be overweight (39%vs 26%) or obese (41% vs 32%), p=0.04. Obese participants were 2.5 times as likely as those with normal BMI (<25) to have reflux symptoms or esophageal erosions. The association between BMI and GERD symptoms persisted in direction and magnitude after adjustment for potential confounders. CONCLUSIONS: Overweight and obesity are strong independent risk factor of GERD symptoms and esophageal erosions. The amount or composition of dietary intake does not appear to be a likely explanation for these findings. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15929752/Obesity_is_an_independent_risk_factor_for_GERD_symptoms_and_erosive_esophagitis_ L2 - http://Insights.ovid.com/pubmed?pmid=15929752 DB - PRIME DP - Unbound Medicine ER -