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[The influence of persistent rapid atrial pacing on the levels of connexin 43 and type III collagen in pulmonary vein and atrium in a canine model].
Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Mar; 33(3):269-72.ZX

Abstract

OBJECTIVE

To investigate the influence of persistent rapid atrial pacing on the levels of connexin 43 (Cx43) and type III collagen in pulmonary vein and atrium in a canine model.

METHODS

Sixteen mongrel dogs were divided into rapid atrial pacing (RAP) group (n = 8) and normal control group (n = 8) randomly. In the RAP group, atrial pacing was performed with a rate of 400 bpm for 10 weeks to establish atrial fibrillation model. The tissues of left superior pulmonary vein (LSPV), left atrial free wall (LAFW) and right atrial appendage (RAA) were collected from each dogs. The levels of Cx43 and type III collagen were measured in each tissue.

RESULTS

Ten weeks later, persistent atrial fibrillation was induced in all dogs in RAP group. The level of Cx43 in RAP group was higher than that in normal control group (LSPV: 3370.91 +/- 275.11 vs 1405.82 +/- 90.38, P < 0.05; LAFW: 2448.68 +/- 272.10 vs 1467.12 +/- 147.93, P < 0.05, RAA: 2331.96 +/- 199.61 vs 1288.27 +/- 216.22, P < 0.05). The level of Cx43 in LSPV was higher than that in LAFW and RAA in RAP group, whereas the difference between LAFW and RAA was not significant in RAP group. The quantities of type III collagen in RAP group were higher than those in normal control group (LSPV: 3301.97 +/- 309.70 vs 1404.56 +/- 178.02, P < 0.05; LAFW: 2477.86 +/- 190.43 vs 1479.20 +/- 187.17, P < 0.05; RAA: 2045.92 +/- 139.43 vs 1417.07 +/- 139.43, P < 0.05). The quantities of type III collagen in LSPV was higher than those in LAFW and RAA in RAP group.

CONCLUSIONS

Persistent rapid atrial pacing could increase the levels of Cx43 and type III collagen in pulmonary vein and atrium in a canine model of atrial fibrillation. The levels of Cx43 and type III collagen in pulmonary vein were higher than those in atrium. This findings indicated that pulmonary vein may be a crucial regions in maintaining atrial fibrillation.

Authors+Show Affiliations

Wang J
Emergency Center, Beijing Anzhen Hospital, Beijing 100029, China.
Liu XP
No affiliation info available
Liu XQ
No affiliation info available
Long DY
No affiliation info available
Dong JZ
No affiliation info available
Ma CS
No affiliation info available

MeSH

AnimalsAtrial FibrillationCardiac Pacing, ArtificialCollagen Type IIIConnexin 43Disease Models, AnimalDogsFemaleMalePulmonary Veins

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15929828

Citation

Wang, Jian, et al. "[The Influence of Persistent Rapid Atrial Pacing On the Levels of Connexin 43 and Type III Collagen in Pulmonary Vein and Atrium in a Canine Model]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 33, no. 3, 2005, pp. 269-72.
Wang J, Liu XP, Liu XQ, et al. [The influence of persistent rapid atrial pacing on the levels of connexin 43 and type III collagen in pulmonary vein and atrium in a canine model]. Zhonghua Xin Xue Guan Bing Za Zhi. 2005;33(3):269-72.
Wang, J., Liu, X. P., Liu, X. Q., Long, D. Y., Dong, J. Z., & Ma, C. S. (2005). [The influence of persistent rapid atrial pacing on the levels of connexin 43 and type III collagen in pulmonary vein and atrium in a canine model]. Zhonghua Xin Xue Guan Bing Za Zhi, 33(3), 269-72.
Wang J, et al. [The Influence of Persistent Rapid Atrial Pacing On the Levels of Connexin 43 and Type III Collagen in Pulmonary Vein and Atrium in a Canine Model]. Zhonghua Xin Xue Guan Bing Za Zhi. 2005;33(3):269-72. PubMed PMID: 15929828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The influence of persistent rapid atrial pacing on the levels of connexin 43 and type III collagen in pulmonary vein and atrium in a canine model]. AU - Wang,Jian, AU - Liu,Xing-peng, AU - Liu,Xiao-qing, AU - Long,De-yong, AU - Dong,Jian-zeng, AU - Ma,Chang-sheng, PY - 2005/6/3/pubmed PY - 2009/12/16/medline PY - 2005/6/3/entrez SP - 269 EP - 72 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 33 IS - 3 N2 - OBJECTIVE: To investigate the influence of persistent rapid atrial pacing on the levels of connexin 43 (Cx43) and type III collagen in pulmonary vein and atrium in a canine model. METHODS: Sixteen mongrel dogs were divided into rapid atrial pacing (RAP) group (n = 8) and normal control group (n = 8) randomly. In the RAP group, atrial pacing was performed with a rate of 400 bpm for 10 weeks to establish atrial fibrillation model. The tissues of left superior pulmonary vein (LSPV), left atrial free wall (LAFW) and right atrial appendage (RAA) were collected from each dogs. The levels of Cx43 and type III collagen were measured in each tissue. RESULTS: Ten weeks later, persistent atrial fibrillation was induced in all dogs in RAP group. The level of Cx43 in RAP group was higher than that in normal control group (LSPV: 3370.91 +/- 275.11 vs 1405.82 +/- 90.38, P < 0.05; LAFW: 2448.68 +/- 272.10 vs 1467.12 +/- 147.93, P < 0.05, RAA: 2331.96 +/- 199.61 vs 1288.27 +/- 216.22, P < 0.05). The level of Cx43 in LSPV was higher than that in LAFW and RAA in RAP group, whereas the difference between LAFW and RAA was not significant in RAP group. The quantities of type III collagen in RAP group were higher than those in normal control group (LSPV: 3301.97 +/- 309.70 vs 1404.56 +/- 178.02, P < 0.05; LAFW: 2477.86 +/- 190.43 vs 1479.20 +/- 187.17, P < 0.05; RAA: 2045.92 +/- 139.43 vs 1417.07 +/- 139.43, P < 0.05). The quantities of type III collagen in LSPV was higher than those in LAFW and RAA in RAP group. CONCLUSIONS: Persistent rapid atrial pacing could increase the levels of Cx43 and type III collagen in pulmonary vein and atrium in a canine model of atrial fibrillation. The levels of Cx43 and type III collagen in pulmonary vein were higher than those in atrium. This findings indicated that pulmonary vein may be a crucial regions in maintaining atrial fibrillation. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/15929828/[The_influence_of_persistent_rapid_atrial_pacing_on_the_levels_of_connexin_43_and_type_III_collagen_in_pulmonary_vein_and_atrium_in_a_canine_model]_ DB - PRIME DP - Unbound Medicine ER -