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Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats.
J Endocrinol 2005; 185(3):457-65JE

Abstract

We have evaluated the influence of oligofructose (OFS), a fermentable dietary fibre, on glucose homeostasis, insulin production and intestinal glucagon-like peptide-1 (GLP-1) in streptozotocin-treated diabetic rats. Male Wistar rats received either i.v. streptozotocin (STZ; 40 mg/kg) or vehicle (CT); one week later, they were fed for 6 weeks with either the standard diet (STZ-CT), or with a diet containing 10% oligofructose (STZ-OFS); both diets were available ad libitum. In a second set of experiments (duration 4 weeks), a supplemental group of food-restricted rats (STZ-Res) receiving a similar intake as CT rats, was added. OFS improved glucose tolerance and reduced food intake as compared with STZ-CT rats in both the post-prandial state and after an oral glucose tolerance test. After 6 weeks, portal and pancreatic insulin concentrations were doubled in STZ-OFS rats. Food restriction improved these parameters when compared with STZ-CT rats, but to a lesser extent than in the STZ-OFS group. We have shown that OFS treatment increased portal and colonic GLP-1(7-36) amide levels and doubled colonic proglucagon and prohormone convertase 1 mRNA levels; both OFS and food restriction lowered ileal GLP-1(7-36) amide levels as compared with levels in STZ-CT rats. We propose that OFS, through its fermentation in the colon, promotes the expression and secretion of colonic peptides, namely GLP-1(7-36) amide, with beneficial consequences on glycaemia, insulin secretion and hyperphagia in diabetic rats.

Authors+Show Affiliations

Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Université catholique de Louvain, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15930172

Citation

Cani, Patrice D., et al. "Involvement of Endogenous Glucagon-like Peptide-1(7-36) Amide On Glycaemia-lowering Effect of Oligofructose in Streptozotocin-treated Rats." The Journal of Endocrinology, vol. 185, no. 3, 2005, pp. 457-65.
Cani PD, Daubioul CA, Reusens B, et al. Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. J Endocrinol. 2005;185(3):457-65.
Cani, P. D., Daubioul, C. A., Reusens, B., Remacle, C., Catillon, G., & Delzenne, N. M. (2005). Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. The Journal of Endocrinology, 185(3), pp. 457-65.
Cani PD, et al. Involvement of Endogenous Glucagon-like Peptide-1(7-36) Amide On Glycaemia-lowering Effect of Oligofructose in Streptozotocin-treated Rats. J Endocrinol. 2005;185(3):457-65. PubMed PMID: 15930172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. AU - Cani,Patrice D, AU - Daubioul,Catherine A, AU - Reusens,Brigitte, AU - Remacle,Claude, AU - Catillon,Grégory, AU - Delzenne,Nathalie M, PY - 2005/6/3/pubmed PY - 2005/7/21/medline PY - 2005/6/3/entrez SP - 457 EP - 65 JF - The Journal of endocrinology JO - J. Endocrinol. VL - 185 IS - 3 N2 - We have evaluated the influence of oligofructose (OFS), a fermentable dietary fibre, on glucose homeostasis, insulin production and intestinal glucagon-like peptide-1 (GLP-1) in streptozotocin-treated diabetic rats. Male Wistar rats received either i.v. streptozotocin (STZ; 40 mg/kg) or vehicle (CT); one week later, they were fed for 6 weeks with either the standard diet (STZ-CT), or with a diet containing 10% oligofructose (STZ-OFS); both diets were available ad libitum. In a second set of experiments (duration 4 weeks), a supplemental group of food-restricted rats (STZ-Res) receiving a similar intake as CT rats, was added. OFS improved glucose tolerance and reduced food intake as compared with STZ-CT rats in both the post-prandial state and after an oral glucose tolerance test. After 6 weeks, portal and pancreatic insulin concentrations were doubled in STZ-OFS rats. Food restriction improved these parameters when compared with STZ-CT rats, but to a lesser extent than in the STZ-OFS group. We have shown that OFS treatment increased portal and colonic GLP-1(7-36) amide levels and doubled colonic proglucagon and prohormone convertase 1 mRNA levels; both OFS and food restriction lowered ileal GLP-1(7-36) amide levels as compared with levels in STZ-CT rats. We propose that OFS, through its fermentation in the colon, promotes the expression and secretion of colonic peptides, namely GLP-1(7-36) amide, with beneficial consequences on glycaemia, insulin secretion and hyperphagia in diabetic rats. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/15930172/Involvement_of_endogenous_glucagon_like_peptide_1_7_36__amide_on_glycaemia_lowering_effect_of_oligofructose_in_streptozotocin_treated_rats_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.1.06100 DB - PRIME DP - Unbound Medicine ER -