Tags

Type your tag names separated by a space and hit enter

Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth.
Aliment Pharmacol Ther. 2005 Jun 01; 21(11):1391-5.AP

Abstract

BACKGROUND

Small intestinal bacterial overgrowth and sugar malabsorption (lactose, fructose, sorbitol) may play a role in irritable bowel syndrome. The lactulose breath test is a reliable and non-invasive test for the diagnosis of small intestinal bacterial overgrowth. The lactose, fructose and sorbitol hydrogen breath tests are widely used to detect specific sugar malabsorption.

AIM

To assess the extent to which small intestinal bacterial overgrowth may influence the results of hydrogen sugar breath tests in irritable bowel syndrome patients.

METHODS

We enrolled 98 consecutive irritable bowel syndrome patients. All subjects underwent hydrogen lactulose, lactose, fructose and sorbitol hydrogen breath tests. Small intestinal bacterial overgrowth patients were treated with 1-week course of antibiotics. All tests were repeated 1 month after the end of therapy.

RESULTS

A positive lactulose breath test was found in 64 of 98 (65%) subjects; these small intestinal bacterial overgrowth patients showed a significantly higher prevalence of positivity to the lactose breath test (P < 0.05), fructose breath test (P < 0.01) and sorbitol breath test (P < 0.01) when compared with the small intestinal bacterial overgrowth-negatives. Small intestinal bacterial overgrowth eradication, as confirmed by negative lactulose breath test, caused a significant reduction in lactose, fructose and sorbitol breath tests positivity (17% vs. 100%, 3% vs. 62%, and 10% vs. 71% respectively: P < 0.0001).

CONCLUSIONS

In irritable bowel syndrome patients with small intestinal bacterial overgrowth, sugar breath tests may be falsely abnormal. Eradication of small intestinal bacterial overgrowth normalizes sugar breath tests in the majority of patients. Testing for small intestinal bacterial overgrowth should be performed before other sugar breath tests tests to avoid sugar malabsorption misdiagnosis.

Authors+Show Affiliations

Internal Medicine Department, Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15932370

Citation

Nucera, G, et al. "Abnormal Breath Tests to Lactose, Fructose and Sorbitol in Irritable Bowel Syndrome May Be Explained By Small Intestinal Bacterial Overgrowth." Alimentary Pharmacology & Therapeutics, vol. 21, no. 11, 2005, pp. 1391-5.
Nucera G, Gabrielli M, Lupascu A, et al. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2005;21(11):1391-5.
Nucera, G., Gabrielli, M., Lupascu, A., Lauritano, E. C., Santoliquido, A., Cremonini, F., Cammarota, G., Tondi, P., Pola, P., Gasbarrini, G., & Gasbarrini, A. (2005). Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Alimentary Pharmacology & Therapeutics, 21(11), 1391-5.
Nucera G, et al. Abnormal Breath Tests to Lactose, Fructose and Sorbitol in Irritable Bowel Syndrome May Be Explained By Small Intestinal Bacterial Overgrowth. Aliment Pharmacol Ther. 2005 Jun 1;21(11):1391-5. PubMed PMID: 15932370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. AU - Nucera,G, AU - Gabrielli,M, AU - Lupascu,A, AU - Lauritano,E C, AU - Santoliquido,A, AU - Cremonini,F, AU - Cammarota,G, AU - Tondi,P, AU - Pola,P, AU - Gasbarrini,G, AU - Gasbarrini,A, PY - 2005/6/4/pubmed PY - 2005/8/16/medline PY - 2005/6/4/entrez SP - 1391 EP - 5 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 21 IS - 11 N2 - BACKGROUND: Small intestinal bacterial overgrowth and sugar malabsorption (lactose, fructose, sorbitol) may play a role in irritable bowel syndrome. The lactulose breath test is a reliable and non-invasive test for the diagnosis of small intestinal bacterial overgrowth. The lactose, fructose and sorbitol hydrogen breath tests are widely used to detect specific sugar malabsorption. AIM: To assess the extent to which small intestinal bacterial overgrowth may influence the results of hydrogen sugar breath tests in irritable bowel syndrome patients. METHODS: We enrolled 98 consecutive irritable bowel syndrome patients. All subjects underwent hydrogen lactulose, lactose, fructose and sorbitol hydrogen breath tests. Small intestinal bacterial overgrowth patients were treated with 1-week course of antibiotics. All tests were repeated 1 month after the end of therapy. RESULTS: A positive lactulose breath test was found in 64 of 98 (65%) subjects; these small intestinal bacterial overgrowth patients showed a significantly higher prevalence of positivity to the lactose breath test (P < 0.05), fructose breath test (P < 0.01) and sorbitol breath test (P < 0.01) when compared with the small intestinal bacterial overgrowth-negatives. Small intestinal bacterial overgrowth eradication, as confirmed by negative lactulose breath test, caused a significant reduction in lactose, fructose and sorbitol breath tests positivity (17% vs. 100%, 3% vs. 62%, and 10% vs. 71% respectively: P < 0.0001). CONCLUSIONS: In irritable bowel syndrome patients with small intestinal bacterial overgrowth, sugar breath tests may be falsely abnormal. Eradication of small intestinal bacterial overgrowth normalizes sugar breath tests in the majority of patients. Testing for small intestinal bacterial overgrowth should be performed before other sugar breath tests tests to avoid sugar malabsorption misdiagnosis. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15932370/Abnormal_breath_tests_to_lactose_fructose_and_sorbitol_in_irritable_bowel_syndrome_may_be_explained_by_small_intestinal_bacterial_overgrowth_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02493.x DB - PRIME DP - Unbound Medicine ER -