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Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide.
Retina 2005; 25(4):503-9R

Abstract

PURPOSE

To evaluate the inhibitory effect of triamcinolone acetonide (TA) on choroidal neovascularization (CNV) by posterior sub-Tenon administration using a laser-induced CNV model in the rat.

METHODS

Experimental CNV was induced by laser photocoagulation in Brown-Norway male rats. Experimental eyes received posterior sub-Tenon administration of either 2 mg (n = 10) or 0.5 mg (n = 8) of TA. Control eyes (n = 10) received posterior sub-Tenon administration of isotonic sodium chloride solution. Two weeks after treatment, CNV was evaluated by fluorescein angiography and histopathological examination. Concentrations of TA in the vitreous, retina, and choroid were determined by high-performance liquid chromatography at 3 and 7 days after posterior sub-Tenon administration.

RESULTS

The eyes treated with 2 mg of TA showed statistically significant inhibition of fluorescein leakage by fluorescein angiography, as compared with control eyes and eyes treated with 0.5 mg of TA (P < 0.01). The thickness of CNV membranes in eyes treated with 2 mg of TA also decreased statistically significantly, as compared with control eyes (P < 0.01). TA was detected in the vitreous, retina, and choroid 3 days after administration and in the choroid 7 days after administration.

CONCLUSIONS

Posterior sub-Tenon administration of TA may be useful to treat CNV.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15933599

Citation

Kato, Aki, et al. "Suppression of Laser-induced Choroidal Neovascularization By Posterior Sub-tenon Administration of Triamcinolone Acetonide." Retina (Philadelphia, Pa.), vol. 25, no. 4, 2005, pp. 503-9.
Kato A, Kimura H, Okabe K, et al. Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide. Retina (Philadelphia, Pa). 2005;25(4):503-9.
Kato, A., Kimura, H., Okabe, K., Okabe, J., Kunou, N., Nozaki, M., & Ogura, Y. (2005). Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide. Retina (Philadelphia, Pa.), 25(4), pp. 503-9.
Kato A, et al. Suppression of Laser-induced Choroidal Neovascularization By Posterior Sub-tenon Administration of Triamcinolone Acetonide. Retina (Philadelphia, Pa). 2005;25(4):503-9. PubMed PMID: 15933599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of laser-induced choroidal neovascularization by posterior sub-tenon administration of triamcinolone acetonide. AU - Kato,Aki, AU - Kimura,Hideya, AU - Okabe,Komei, AU - Okabe,Junko, AU - Kunou,Noriyuki, AU - Nozaki,Miho, AU - Ogura,Yuichiro, PY - 2005/6/4/pubmed PY - 2005/8/3/medline PY - 2005/6/4/entrez SP - 503 EP - 9 JF - Retina (Philadelphia, Pa.) JO - Retina (Philadelphia, Pa.) VL - 25 IS - 4 N2 - PURPOSE: To evaluate the inhibitory effect of triamcinolone acetonide (TA) on choroidal neovascularization (CNV) by posterior sub-Tenon administration using a laser-induced CNV model in the rat. METHODS: Experimental CNV was induced by laser photocoagulation in Brown-Norway male rats. Experimental eyes received posterior sub-Tenon administration of either 2 mg (n = 10) or 0.5 mg (n = 8) of TA. Control eyes (n = 10) received posterior sub-Tenon administration of isotonic sodium chloride solution. Two weeks after treatment, CNV was evaluated by fluorescein angiography and histopathological examination. Concentrations of TA in the vitreous, retina, and choroid were determined by high-performance liquid chromatography at 3 and 7 days after posterior sub-Tenon administration. RESULTS: The eyes treated with 2 mg of TA showed statistically significant inhibition of fluorescein leakage by fluorescein angiography, as compared with control eyes and eyes treated with 0.5 mg of TA (P < 0.01). The thickness of CNV membranes in eyes treated with 2 mg of TA also decreased statistically significantly, as compared with control eyes (P < 0.01). TA was detected in the vitreous, retina, and choroid 3 days after administration and in the choroid 7 days after administration. CONCLUSIONS: Posterior sub-Tenon administration of TA may be useful to treat CNV. SN - 0275-004X UR - https://www.unboundmedicine.com/medline/citation/15933599/Suppression_of_laser_induced_choroidal_neovascularization_by_posterior_sub_tenon_administration_of_triamcinolone_acetonide_ L2 - http://dx.doi.org/10.1097/00006982-200506000-00017 DB - PRIME DP - Unbound Medicine ER -