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No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome.
Genes Immun. 2005 Aug; 6(5):457-8.GI

Abstract

One-third of first-degree relatives of patients with primary Sjögren's syndrome (pSS) suffer from other autoimmune diseases, including type I diabetes, systemic lupus erythematosus and autoimmune thyroiditis. Recently, 1858 C/T polymorphism of PTPN22 gene was reported to predispose to these autoimmune diseases. We decided to investigate whether PTPN22 gene polymorphism was also involved in the genetic predisposition to pSS in a case-control study, including 183 patients with pSS and 172 healthy controls. No significant differences in allele (T allele frequency: 7.7% in patients with pSS vs 7.8% in controls, P=0.9) and genotype frequencies of PTPN22 polymorphism were detected between patients with pSS and controls. PTPN 22 gene polymorphism was not associated with a specific pattern of autoantibody secretion either. Thus, 1858 C/T polymorphism of PTPN22 gene is not involved in genetic predisposition to pSS.

Authors+Show Affiliations

Service de Rhumatologie, Institut Pour la Santé et la Recherche Médicale E 109, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15933742

Citation

Ittah, M, et al. "No Evidence for Association Between 1858 C/T Single-nucleotide Polymorphism of PTPN22 Gene and Primary Sjögren's Syndrome." Genes and Immunity, vol. 6, no. 5, 2005, pp. 457-8.
Ittah M, Gottenberg JE, Proust A, et al. No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome. Genes Immun. 2005;6(5):457-8.
Ittah, M., Gottenberg, J. E., Proust, A., Hachulla, E., Puechal, X., Loiseau, P., Mariette, X., & Miceli-Richard, C. (2005). No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome. Genes and Immunity, 6(5), 457-8.
Ittah M, et al. No Evidence for Association Between 1858 C/T Single-nucleotide Polymorphism of PTPN22 Gene and Primary Sjögren's Syndrome. Genes Immun. 2005;6(5):457-8. PubMed PMID: 15933742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome. AU - Ittah,M, AU - Gottenberg,J-E, AU - Proust,A, AU - Hachulla,E, AU - Puechal,X, AU - Loiseau,P, AU - Mariette,X, AU - Miceli-Richard,C, PY - 2005/6/4/pubmed PY - 2005/12/13/medline PY - 2005/6/4/entrez SP - 457 EP - 8 JF - Genes and immunity JO - Genes Immun VL - 6 IS - 5 N2 - One-third of first-degree relatives of patients with primary Sjögren's syndrome (pSS) suffer from other autoimmune diseases, including type I diabetes, systemic lupus erythematosus and autoimmune thyroiditis. Recently, 1858 C/T polymorphism of PTPN22 gene was reported to predispose to these autoimmune diseases. We decided to investigate whether PTPN22 gene polymorphism was also involved in the genetic predisposition to pSS in a case-control study, including 183 patients with pSS and 172 healthy controls. No significant differences in allele (T allele frequency: 7.7% in patients with pSS vs 7.8% in controls, P=0.9) and genotype frequencies of PTPN22 polymorphism were detected between patients with pSS and controls. PTPN 22 gene polymorphism was not associated with a specific pattern of autoantibody secretion either. Thus, 1858 C/T polymorphism of PTPN22 gene is not involved in genetic predisposition to pSS. SN - 1466-4879 UR - https://www.unboundmedicine.com/medline/citation/15933742/No_evidence_for_association_between_1858_C/T_single_nucleotide_polymorphism_of_PTPN22_gene_and_primary_Sjögren's_syndrome_ L2 - https://doi.org/10.1038/sj.gene.6364229 DB - PRIME DP - Unbound Medicine ER -