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Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.
Acta Neuropathol. 2005 Jun; 109(6):583-8.AN

Abstract

Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [123I]MIBG myocardial scintigraphy has been reported in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We hypothesized that cardiac sympathetic denervation might account for the pathomechanism. To elucidate the extent, frequency and pattern of cardiac sympathetic nerve involvement in Lewy body disease and related neurodegenerative disorders, we immunohistochemically examined heart tissues from patients with PD (n=11), DLB (n=7), DLB with Alzheimer's disease (DLB/AD; n=4), multiple system atrophy (MSA; n=8), progressive supranuclear palsy (PSP; n=5), pure AD (n=10) and control subjects (n=5) together with sympathetic ganglia from patients with PD (n=5) and control subjects (n=4), using an antibody against tyrosine hydroxylase (TH). TH-immunoreactive nerve fibers in the hearts had almost entirely disappeared in nearly all the patients with PD, DLB and DLB/AD, whereas they were well preserved in all the patients with PSP and pure AD as well as in all except for one patient with MSA. In PD, neurons in the sympathetic ganglia were preserved in all except for one patient. Decreased cardiac uptake of MIBG in Lewy body disease reflects actual cardiac sympathetic denervation, which precedes the neuronal loss in the sympathetic ganglia.

Authors+Show Affiliations

Department of Neurology, Kanto Central Hospital, 6-25-1 Kami-Yoga, Setagaya-ku, 158-8531, Tokyo, Japan. orimo@kanto-ctr-hsp.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15933869

Citation

Orimo, Satoshi, et al. "Cardiac Sympathetic Denervation Precedes Neuronal Loss in the Sympathetic Ganglia in Lewy Body Disease." Acta Neuropathologica, vol. 109, no. 6, 2005, pp. 583-8.
Orimo S, Amino T, Itoh Y, et al. Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathol. 2005;109(6):583-8.
Orimo, S., Amino, T., Itoh, Y., Takahashi, A., Kojo, T., Uchihara, T., Tsuchiya, K., Mori, F., Wakabayashi, K., & Takahashi, H. (2005). Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathologica, 109(6), 583-8.
Orimo S, et al. Cardiac Sympathetic Denervation Precedes Neuronal Loss in the Sympathetic Ganglia in Lewy Body Disease. Acta Neuropathol. 2005;109(6):583-8. PubMed PMID: 15933869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. AU - Orimo,Satoshi, AU - Amino,Takeshi, AU - Itoh,Yoshinori, AU - Takahashi,Atsushi, AU - Kojo,Tohru, AU - Uchihara,Toshiki, AU - Tsuchiya,Kuniaki, AU - Mori,Fumiaki, AU - Wakabayashi,Koichi, AU - Takahashi,Hitoshi, Y1 - 2005/06/03/ PY - 2004/12/03/received PY - 2005/02/03/accepted PY - 2005/01/11/revised PY - 2005/6/4/pubmed PY - 2005/10/5/medline PY - 2005/6/4/entrez SP - 583 EP - 8 JF - Acta neuropathologica JO - Acta Neuropathol VL - 109 IS - 6 N2 - Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [123I]MIBG myocardial scintigraphy has been reported in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We hypothesized that cardiac sympathetic denervation might account for the pathomechanism. To elucidate the extent, frequency and pattern of cardiac sympathetic nerve involvement in Lewy body disease and related neurodegenerative disorders, we immunohistochemically examined heart tissues from patients with PD (n=11), DLB (n=7), DLB with Alzheimer's disease (DLB/AD; n=4), multiple system atrophy (MSA; n=8), progressive supranuclear palsy (PSP; n=5), pure AD (n=10) and control subjects (n=5) together with sympathetic ganglia from patients with PD (n=5) and control subjects (n=4), using an antibody against tyrosine hydroxylase (TH). TH-immunoreactive nerve fibers in the hearts had almost entirely disappeared in nearly all the patients with PD, DLB and DLB/AD, whereas they were well preserved in all the patients with PSP and pure AD as well as in all except for one patient with MSA. In PD, neurons in the sympathetic ganglia were preserved in all except for one patient. Decreased cardiac uptake of MIBG in Lewy body disease reflects actual cardiac sympathetic denervation, which precedes the neuronal loss in the sympathetic ganglia. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/15933869/Cardiac_sympathetic_denervation_precedes_neuronal_loss_in_the_sympathetic_ganglia_in_Lewy_body_disease_ L2 - https://dx.doi.org/10.1007/s00401-005-0995-7 DB - PRIME DP - Unbound Medicine ER -