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Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: the paradoxical effect of the superimposed type II diabetes mellitus condition.
Clin Chim Acta. 2005 Sep; 359(1-2):163-70.CC

Abstract

BACKGROUND

Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases.

METHODS

The sample (n=122; males=60; mean age=73+/-7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD+DM, VaD+DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate.

RESULTS

The one-way ANOVA yielded significant differences between groups for all variables: tHcy p<10(-12); B12 p<10(-3); FOL p<10(-4). Significance for comparisons between groups was set at alpha=0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD+DM vs. AD, VaD+DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons.

CONCLUSIONS

In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias.

Authors+Show Affiliations

Facultad de Medicina, Hospital Sirio-Libanés-UBA, FACENE, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15935339

Citation

Domínguez, Raúl O., et al. "Homocysteine, Vitamin B 12 and Folate in Alzheimer's and Vascular Dementias: the Paradoxical Effect of the Superimposed Type II Diabetes Mellitus Condition." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 359, no. 1-2, 2005, pp. 163-70.
Domínguez RO, Marschoff ER, Guareschi EM, et al. Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: the paradoxical effect of the superimposed type II diabetes mellitus condition. Clin Chim Acta. 2005;359(1-2):163-70.
Domínguez, R. O., Marschoff, E. R., Guareschi, E. M., Famulari, A. L., Pagano, M. A., & Serra, J. A. (2005). Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: the paradoxical effect of the superimposed type II diabetes mellitus condition. Clinica Chimica Acta; International Journal of Clinical Chemistry, 359(1-2), 163-70.
Domínguez RO, et al. Homocysteine, Vitamin B 12 and Folate in Alzheimer's and Vascular Dementias: the Paradoxical Effect of the Superimposed Type II Diabetes Mellitus Condition. Clin Chim Acta. 2005;359(1-2):163-70. PubMed PMID: 15935339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: the paradoxical effect of the superimposed type II diabetes mellitus condition. AU - Domínguez,Raúl O, AU - Marschoff,Enrique R, AU - Guareschi,Eduardo M, AU - Famulari,Arturo L, AU - Pagano,Miguel A, AU - Serra,Jorge A, AU - ,, PY - 2005/02/02/received PY - 2005/03/18/revised PY - 2005/03/24/accepted PY - 2005/6/7/pubmed PY - 2005/11/8/medline PY - 2005/6/7/entrez SP - 163 EP - 70 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 359 IS - 1-2 N2 - BACKGROUND: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. METHODS: The sample (n=122; males=60; mean age=73+/-7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD+DM, VaD+DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate. RESULTS: The one-way ANOVA yielded significant differences between groups for all variables: tHcy p<10(-12); B12 p<10(-3); FOL p<10(-4). Significance for comparisons between groups was set at alpha=0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD+DM vs. AD, VaD+DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons. CONCLUSIONS: In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15935339/Homocysteine_vitamin_B_12_and_folate_in_Alzheimer's_and_vascular_dementias:_the_paradoxical_effect_of_the_superimposed_type_II_diabetes_mellitus_condition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(05)00237-8 DB - PRIME DP - Unbound Medicine ER -