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Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone.
Biomaterials 2005; 26(33):6736-42B

Abstract

Novel BAB type amphiphilic triblock copolymers consisting of poly (ethylene glycol) (PEG) (B) as hydrophilic segment and poly (epsilon-caprolactone) (PCL) (A) as hydrophobic block were prepared by coupling reaction using L-lysine methyl ester diisocyanate (LDI) as the chain extender. The triblock copolymers obtained were characterized by FT-IR, 1H NMR, GPC, and DSC. Core-shell type nanoparticles were prepared by nanoprecipitation method and below 100 nm nanoparticles were obtained due to their specific structure. Transmission electron microscopy image demonstrated that these nanoparticles were spherical in shape. Stability of the nanoparticles in biological media was evaluated. Poorly water-soluble anticancer drug 4'-demethyl-epipodophyllotoxin (DMEP) was chosen for controlled drug release because it was easily encapsulated into polymeric nanoparticles via hydrophobic interaction. In vitro release behavior of DMEP from polymeric nanoparticles was investigated, the results showed that the drug release rate can be modulated by the variation of the copolymer composition.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of the Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15935469

Citation

Zhang, Ying, and Ren-xi Zhuo. "Synthesis and in Vitro Drug Release Behavior of Amphiphilic Triblock Copolymer Nanoparticles Based On Poly (ethylene Glycol) and Polycaprolactone." Biomaterials, vol. 26, no. 33, 2005, pp. 6736-42.
Zhang Y, Zhuo RX. Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone. Biomaterials. 2005;26(33):6736-42.
Zhang, Y., & Zhuo, R. X. (2005). Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone. Biomaterials, 26(33), pp. 6736-42.
Zhang Y, Zhuo RX. Synthesis and in Vitro Drug Release Behavior of Amphiphilic Triblock Copolymer Nanoparticles Based On Poly (ethylene Glycol) and Polycaprolactone. Biomaterials. 2005;26(33):6736-42. PubMed PMID: 15935469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone. AU - Zhang,Ying, AU - Zhuo,Ren-xi, PY - 2004/10/24/received PY - 2005/03/31/accepted PY - 2005/6/7/pubmed PY - 2005/10/12/medline PY - 2005/6/7/entrez SP - 6736 EP - 42 JF - Biomaterials JO - Biomaterials VL - 26 IS - 33 N2 - Novel BAB type amphiphilic triblock copolymers consisting of poly (ethylene glycol) (PEG) (B) as hydrophilic segment and poly (epsilon-caprolactone) (PCL) (A) as hydrophobic block were prepared by coupling reaction using L-lysine methyl ester diisocyanate (LDI) as the chain extender. The triblock copolymers obtained were characterized by FT-IR, 1H NMR, GPC, and DSC. Core-shell type nanoparticles were prepared by nanoprecipitation method and below 100 nm nanoparticles were obtained due to their specific structure. Transmission electron microscopy image demonstrated that these nanoparticles were spherical in shape. Stability of the nanoparticles in biological media was evaluated. Poorly water-soluble anticancer drug 4'-demethyl-epipodophyllotoxin (DMEP) was chosen for controlled drug release because it was easily encapsulated into polymeric nanoparticles via hydrophobic interaction. In vitro release behavior of DMEP from polymeric nanoparticles was investigated, the results showed that the drug release rate can be modulated by the variation of the copolymer composition. SN - 0142-9612 UR - https://www.unboundmedicine.com/medline/citation/15935469/Synthesis_and_in_vitro_drug_release_behavior_of_amphiphilic_triblock_copolymer_nanoparticles_based_on_poly__ethylene_glycol__and_polycaprolactone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0142-9612(05)00292-9 DB - PRIME DP - Unbound Medicine ER -