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Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals.
J Rheumatol. 1992 Apr; 19(4):600-3.JR

Abstract

Synovial fluid (SF) samples, all containing monosodium urate crystals, obtained from 18 asymptomatic knees of 12 patients with gout, were serially analyzed before and one month after treatment with 1 mg/day of oral colchicine. Before treatment, the SF contained 612 [confidence limits (CL) = 282, 942] cells/mm3, while after treatment these values decreased to 274 (CL = 73, 471) cells/mm3 (p less than 0.005). In all cases, pretreatment cell counts were higher than the corresponding posttreatment values. The percentage of polymorphonuclear leukocytes also diminished from a pretreatment value of 13.0 (CL = 7, 19) to 4.5 (CL = 2, 7) after colchicine administration (p less than 0.005). These results strongly suggest the presence of baseline subclinical joint inflammation which is reduced by colchicine. The preventive effect of this drug on the occurrence of new attacks may relate to its effect in reducing the baseline inflammation of the asymptomatic joints.

Authors+Show Affiliations

Pascual E
Rheumatology Section, Hospital General de Alicante, Spain.
Castellano JA
No affiliation info available

MeSH

ColchicineCrystallizationGoutHumansKnee JointLeukocyte CountNeutrophilsSynovial FluidUric Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1593582

Citation

Pascual, E, and J A. Castellano. "Treatment With Colchicine Decreases White Cell Counts in Synovial Fluid of Asymptomatic Knees That Contain Monosodium Urate Crystals." The Journal of Rheumatology, vol. 19, no. 4, 1992, pp. 600-3.
Pascual E, Castellano JA. Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals. J Rheumatol. 1992;19(4):600-3.
Pascual, E., & Castellano, J. A. (1992). Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals. The Journal of Rheumatology, 19(4), 600-3.
Pascual E, Castellano JA. Treatment With Colchicine Decreases White Cell Counts in Synovial Fluid of Asymptomatic Knees That Contain Monosodium Urate Crystals. J Rheumatol. 1992;19(4):600-3. PubMed PMID: 1593582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals. AU - Pascual,E, AU - Castellano,J A, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 600 EP - 3 JF - The Journal of rheumatology JO - J Rheumatol VL - 19 IS - 4 N2 - Synovial fluid (SF) samples, all containing monosodium urate crystals, obtained from 18 asymptomatic knees of 12 patients with gout, were serially analyzed before and one month after treatment with 1 mg/day of oral colchicine. Before treatment, the SF contained 612 [confidence limits (CL) = 282, 942] cells/mm3, while after treatment these values decreased to 274 (CL = 73, 471) cells/mm3 (p less than 0.005). In all cases, pretreatment cell counts were higher than the corresponding posttreatment values. The percentage of polymorphonuclear leukocytes also diminished from a pretreatment value of 13.0 (CL = 7, 19) to 4.5 (CL = 2, 7) after colchicine administration (p less than 0.005). These results strongly suggest the presence of baseline subclinical joint inflammation which is reduced by colchicine. The preventive effect of this drug on the occurrence of new attacks may relate to its effect in reducing the baseline inflammation of the asymptomatic joints. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/1593582/Treatment_with_colchicine_decreases_white_cell_counts_in_synovial_fluid_of_asymptomatic_knees_that_contain_monosodium_urate_crystals_ DB - PRIME DP - Unbound Medicine ER -