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Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report.
Gynecol Oncol. 2005 Aug; 98(2):322-4.GO

Abstract

BACKGROUND

Metastatic bone involvement in vulvar squamous carcinoma is very rare. Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis.

CASE

A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus. A right hemivulvectomy was performed with ipsilateral inguinofemoral lymphadenectomy, revealing a primary adenocarcinoma of the Bartholin's gland and metastatic involvement in 6 out of 13 lymphnodes. During chemotherapy administration, the patient started complaining of a worsening of right hypoacousis. CT scan and MRI of the brain showed the presence of a metastatic lesion on the right side of the skullbone. The diagnosis was metastatic poorly differentiated adenocarcinoma.

CONCLUSION

In adenocarcinoma of the Bartholin's gland at an advanced stage of disease, a bone scan or survey in the preoperative as well as follow up staging procedures could be useful.

Authors+Show Affiliations

Gynecologic Oncology Unit, Catholic University of Rome, Italy. gabriella.ferrandina@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15936060

Citation

Ferrandina, G, et al. "Skull Metastasis in Primary Vulvar Adenocarcinoma of the Bartholin's Gland: a Case Report." Gynecologic Oncology, vol. 98, no. 2, 2005, pp. 322-4.
Ferrandina G, Testa AC, Zannoni GF, et al. Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. Gynecol Oncol. 2005;98(2):322-4.
Ferrandina, G., Testa, A. C., Zannoni, G. F., Poerio, A., & Scambia, G. (2005). Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. Gynecologic Oncology, 98(2), 322-4.
Ferrandina G, et al. Skull Metastasis in Primary Vulvar Adenocarcinoma of the Bartholin's Gland: a Case Report. Gynecol Oncol. 2005;98(2):322-4. PubMed PMID: 15936060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. AU - Ferrandina,G, AU - Testa,A C, AU - Zannoni,G F, AU - Poerio,A, AU - Scambia,G, PY - 2005/01/28/received PY - 2005/03/17/revised PY - 2005/04/18/accepted PY - 2005/6/7/pubmed PY - 2005/9/28/medline PY - 2005/6/7/entrez SP - 322 EP - 4 JF - Gynecologic oncology JO - Gynecol Oncol VL - 98 IS - 2 N2 - BACKGROUND: Metastatic bone involvement in vulvar squamous carcinoma is very rare. Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis. CASE: A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus. A right hemivulvectomy was performed with ipsilateral inguinofemoral lymphadenectomy, revealing a primary adenocarcinoma of the Bartholin's gland and metastatic involvement in 6 out of 13 lymphnodes. During chemotherapy administration, the patient started complaining of a worsening of right hypoacousis. CT scan and MRI of the brain showed the presence of a metastatic lesion on the right side of the skullbone. The diagnosis was metastatic poorly differentiated adenocarcinoma. CONCLUSION: In adenocarcinoma of the Bartholin's gland at an advanced stage of disease, a bone scan or survey in the preoperative as well as follow up staging procedures could be useful. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/15936060/Skull_metastasis_in_primary_vulvar_adenocarcinoma_of_the_Bartholin's_gland:_a_case_report_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(05)00311-2 DB - PRIME DP - Unbound Medicine ER -