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The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity.
Diabetes Res Clin Pract. 2005 Jun; 68(3):217-22.DR

Abstract

AIM

We investigated the relationship between insulin resistance and serum osteoprotegerin (OPG) levels in healthy obese subjects and healthy lean controls.

METHODS

Fifty obese subjects (age: 31+/-8 years) and 24 lean controls (age: 30+/-7 years) were included in the study. We used the homeostasis model assessment for insulin resistance (HOMA-IR) index as the index of insulin resistance. OPG levels were measured with the commercial ELISA kit. Obese subjects were studied in three groups: Group I (n = 25) HOMA-IR index < 2.24, Group II (n = 13) index 2.24-3.59, Group III (n = 12) index > 3.59. Group IV (n = 24) was the lean controls with HOMA-IR index < 2.24.

RESULTS

Obese subjects with increased insulin resistance (Group III) had lower OPG values than other groups (11.88+/-7.43 pg/ml, 16.39+/-6.39 pg/ml, 17.37+/-9.61 pg/ml, and 18.1+/-6.65 pg/ml, respectively; Group I versus Group III p = 0.036; Group III versus Group IV p = 0.012). We also found significant inverse correlations between OPGc (corrected for BMI) and fasting glucose (r = -0.325, p = 0.005), fasting insulin (r = -0.404, p = 0.0001) as well as HOMA-IR (r = -0.428, p = 0.0001). Increased fibrinogen level was found in Group III than Group IV (9.32+/-1.97 micromol/l versus 7.47+/-1.65 micromol/l, respectively; p = 0.005). In conclusion, insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels. The relationship between serum OPG levels and HOMA-IR may provide an insight into vascular endothelial dysfunction in obesity.

Authors+Show Affiliations

Trakya University, Medical School, Department of Endocrinology and Metabolism, Edirne, Turkey. altun@medscape.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15936463

Citation

Ugur-Altun, Betul, et al. "The Relationship Between Insulin Resistance Assessed By HOMA-IR and Serum Osteoprotegerin Levels in Obesity." Diabetes Research and Clinical Practice, vol. 68, no. 3, 2005, pp. 217-22.
Ugur-Altun B, Altun A, Gerenli M, et al. The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity. Diabetes Res Clin Pract. 2005;68(3):217-22.
Ugur-Altun, B., Altun, A., Gerenli, M., & Tugrul, A. (2005). The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity. Diabetes Research and Clinical Practice, 68(3), 217-22.
Ugur-Altun B, et al. The Relationship Between Insulin Resistance Assessed By HOMA-IR and Serum Osteoprotegerin Levels in Obesity. Diabetes Res Clin Pract. 2005;68(3):217-22. PubMed PMID: 15936463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity. AU - Ugur-Altun,Betul, AU - Altun,Armagan, AU - Gerenli,Murat, AU - Tugrul,Armagan, Y1 - 2005/01/18/ PY - 2004/08/04/received PY - 2004/10/11/revised PY - 2004/10/25/accepted PY - 2005/6/7/pubmed PY - 2005/12/13/medline PY - 2005/6/7/entrez SP - 217 EP - 22 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 68 IS - 3 N2 - AIM: We investigated the relationship between insulin resistance and serum osteoprotegerin (OPG) levels in healthy obese subjects and healthy lean controls. METHODS: Fifty obese subjects (age: 31+/-8 years) and 24 lean controls (age: 30+/-7 years) were included in the study. We used the homeostasis model assessment for insulin resistance (HOMA-IR) index as the index of insulin resistance. OPG levels were measured with the commercial ELISA kit. Obese subjects were studied in three groups: Group I (n = 25) HOMA-IR index < 2.24, Group II (n = 13) index 2.24-3.59, Group III (n = 12) index > 3.59. Group IV (n = 24) was the lean controls with HOMA-IR index < 2.24. RESULTS: Obese subjects with increased insulin resistance (Group III) had lower OPG values than other groups (11.88+/-7.43 pg/ml, 16.39+/-6.39 pg/ml, 17.37+/-9.61 pg/ml, and 18.1+/-6.65 pg/ml, respectively; Group I versus Group III p = 0.036; Group III versus Group IV p = 0.012). We also found significant inverse correlations between OPGc (corrected for BMI) and fasting glucose (r = -0.325, p = 0.005), fasting insulin (r = -0.404, p = 0.0001) as well as HOMA-IR (r = -0.428, p = 0.0001). Increased fibrinogen level was found in Group III than Group IV (9.32+/-1.97 micromol/l versus 7.47+/-1.65 micromol/l, respectively; p = 0.005). In conclusion, insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels. The relationship between serum OPG levels and HOMA-IR may provide an insight into vascular endothelial dysfunction in obesity. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/15936463/The_relationship_between_insulin_resistance_assessed_by_HOMA_IR_and_serum_osteoprotegerin_levels_in_obesity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(04)00420-6 DB - PRIME DP - Unbound Medicine ER -