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Apolipoprotein e4 allele and the risk of CAD death in type 2 diabetes mellitus with ischaemia electrocardiographic change.
Diabetes Res Clin Pract. 2005 Jun; 68(3):223-9.DR

Abstract

The presence of apolipoprotein (Apo) e4 allele is reported to be associated with the increased risk of coronary artery disease (CAD), as well as the impairment of endothelium-dependent arterial dilation in type 2 diabetes mellitus. Therefore, we hypothesized that Apo e4 allele increases the death risk from coronary artery disease in type 2 diabetes with ischaemia electrocardiographic change. From January 1993 to December 1999, 46 type 2 diabetic patients with e4/4 or e4/3, 96 with e3/3 and 45 with e2/2 or e3/2 genotypes were recruited. All subjects were unrelated elderly type 2 diabetic patients with ischaemia electrocardiographic change, aged 60-87 years, and their cardiac function were all the class I stage at their time of enrollment. A follow-up study of 3-10 years was undergone. The results are as follows: At baseline, serum total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were higher in subjects with e4/3 or e4/4 than in subjects with e2/2 or e3/2 (p<0.05). Lipoprotein(a) concentration was lower in subjects with e2/2 or e3/2 than in subjects with e3/3 and e4/3 or e4/4 (p < 0.05). During the 3-10 years follow-up period, a total of 55 patients who died from CAD were recorded in this sample. Compared with patients with e3/3 (p = 0.024) and patients with e2/2 or e2/3 genotypes (p = 0.002), the mortality rate of CAD in patients with e4/3 or e4/4 genotypes was the highest (47.8%). Stepwise discriminant analysis revealed that in the diabetic population studied Apo e4 allele was independently and significantly associated with CAD death (B = 0.65). However, the strength of the association decreased (B = 0.44) when total cholesterol, LDL-cholesterol and lipoprotein(a) were included in the model. Therefore, we concluded that Apo e4 allele increases the risk of CAD death in elderly type 2 diabetes mellitus with ischaemia electrocardiographic change.

Authors+Show Affiliations

Department of Endocrinology, Wuhan General Hospital of Guangzhou Command of PLA, Wuhan 430070, PR China. guangda64@163.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15936464

Citation

Guang-da, Xiang, et al. "Apolipoprotein E4 Allele and the Risk of CAD Death in Type 2 Diabetes Mellitus With Ischaemia Electrocardiographic Change." Diabetes Research and Clinical Practice, vol. 68, no. 3, 2005, pp. 223-9.
Guang-da X, Xiang-Jiu Y, Lin-Shuang Z, et al. Apolipoprotein e4 allele and the risk of CAD death in type 2 diabetes mellitus with ischaemia electrocardiographic change. Diabetes Res Clin Pract. 2005;68(3):223-9.
Guang-da, X., Xiang-Jiu, Y., Lin-Shuang, Z., Zhi-Song, C., & Yu-Sheng, H. (2005). Apolipoprotein e4 allele and the risk of CAD death in type 2 diabetes mellitus with ischaemia electrocardiographic change. Diabetes Research and Clinical Practice, 68(3), 223-9.
Guang-da X, et al. Apolipoprotein E4 Allele and the Risk of CAD Death in Type 2 Diabetes Mellitus With Ischaemia Electrocardiographic Change. Diabetes Res Clin Pract. 2005;68(3):223-9. PubMed PMID: 15936464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein e4 allele and the risk of CAD death in type 2 diabetes mellitus with ischaemia electrocardiographic change. AU - Guang-da,Xiang, AU - Xiang-Jiu,Yang, AU - Lin-Shuang,Zhao, AU - Zhi-Song,Chen, AU - Yu-Sheng,He, PY - 2003/09/10/received PY - 2004/08/13/revised PY - 2004/09/06/accepted PY - 2005/6/7/pubmed PY - 2005/12/13/medline PY - 2005/6/7/entrez SP - 223 EP - 9 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 68 IS - 3 N2 - The presence of apolipoprotein (Apo) e4 allele is reported to be associated with the increased risk of coronary artery disease (CAD), as well as the impairment of endothelium-dependent arterial dilation in type 2 diabetes mellitus. Therefore, we hypothesized that Apo e4 allele increases the death risk from coronary artery disease in type 2 diabetes with ischaemia electrocardiographic change. From January 1993 to December 1999, 46 type 2 diabetic patients with e4/4 or e4/3, 96 with e3/3 and 45 with e2/2 or e3/2 genotypes were recruited. All subjects were unrelated elderly type 2 diabetic patients with ischaemia electrocardiographic change, aged 60-87 years, and their cardiac function were all the class I stage at their time of enrollment. A follow-up study of 3-10 years was undergone. The results are as follows: At baseline, serum total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were higher in subjects with e4/3 or e4/4 than in subjects with e2/2 or e3/2 (p<0.05). Lipoprotein(a) concentration was lower in subjects with e2/2 or e3/2 than in subjects with e3/3 and e4/3 or e4/4 (p < 0.05). During the 3-10 years follow-up period, a total of 55 patients who died from CAD were recorded in this sample. Compared with patients with e3/3 (p = 0.024) and patients with e2/2 or e2/3 genotypes (p = 0.002), the mortality rate of CAD in patients with e4/3 or e4/4 genotypes was the highest (47.8%). Stepwise discriminant analysis revealed that in the diabetic population studied Apo e4 allele was independently and significantly associated with CAD death (B = 0.65). However, the strength of the association decreased (B = 0.44) when total cholesterol, LDL-cholesterol and lipoprotein(a) were included in the model. Therefore, we concluded that Apo e4 allele increases the risk of CAD death in elderly type 2 diabetes mellitus with ischaemia electrocardiographic change. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/15936464/Apolipoprotein_e4_allele_and_the_risk_of_CAD_death_in_type_2_diabetes_mellitus_with_ischaemia_electrocardiographic_change_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(04)00289-X DB - PRIME DP - Unbound Medicine ER -