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Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile.
Diabetes Res Clin Pract. 2005 Jun; 68(3):244-9.DR

Abstract

Apolipoprotein E (apo E) modulates the metabolism of atherogenic lipoprotein particles and participates in the process of cellular incorporation of specific lipoproteins. Genetic polymorphism of apo E has been reported as an important dyslipidemia genetic marker associated with coronary artery disease. Type 2 diabetes mellitus is a disease with a high incidence and prevalence in the world. The main cause of death in these patients is myocardial stroke and a high incidence of general cardiovascular complications. The purpose of this work was to characterize the genotype of apo E in diabetic patients from Talca, Chile, in order to describe the allelic frequency of the apo E gene and its correlation to the lipids profile. Type 2 diabetic patients (200) were recruited from the Diabetes Program of Talca Hospital, Chile. Apo E genotype was determined by restriction fragment-length polymorphism analysis. A biochemical characterization was performed in all the subjects. Type 2 diabetic patients had elevated levels of glycemia, lipid profile and BMI compared to the control group. The E3/3 genotype and epsilon3 allele had a higher frequency in both groups. The E2/3 and E3/4 genotypes had higher levels of triglyceride (TG) and cholesterol respectively; however, there was not any statistical relationship between them. In conclusion, genotype of apo E in diabetic patients did not differ with healthy; E2/3 and E3/4 genotypes tend to have higher levels of triglyceride and cholesterol respectively. We think that these results corroborate that in the etiology of the dyslipidemia, there is more than one associate genetic marker.

Authors+Show Affiliations

Laboratorio de Bioquímica Clínica, Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile. eleivam@utalca.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15936467

Citation

Leiva, Elba, et al. "Apolipoprotein E Polymorphism in Type 2 Diabetic Patients of Talca, Chile." Diabetes Research and Clinical Practice, vol. 68, no. 3, 2005, pp. 244-9.
Leiva E, Mujica V, Orrego R, et al. Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile. Diabetes Res Clin Pract. 2005;68(3):244-9.
Leiva, E., Mujica, V., Orrego, R., Prieto, M., & Arredondo, M. (2005). Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile. Diabetes Research and Clinical Practice, 68(3), 244-9.
Leiva E, et al. Apolipoprotein E Polymorphism in Type 2 Diabetic Patients of Talca, Chile. Diabetes Res Clin Pract. 2005;68(3):244-9. PubMed PMID: 15936467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile. AU - Leiva,Elba, AU - Mujica,Verónica, AU - Orrego,Roxana, AU - Prieto,María, AU - Arredondo,Miguel, Y1 - 2005/01/26/ PY - 2004/02/16/received PY - 2004/07/06/revised PY - 2004/09/27/accepted PY - 2005/6/7/pubmed PY - 2005/12/13/medline PY - 2005/6/7/entrez SP - 244 EP - 9 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 68 IS - 3 N2 - Apolipoprotein E (apo E) modulates the metabolism of atherogenic lipoprotein particles and participates in the process of cellular incorporation of specific lipoproteins. Genetic polymorphism of apo E has been reported as an important dyslipidemia genetic marker associated with coronary artery disease. Type 2 diabetes mellitus is a disease with a high incidence and prevalence in the world. The main cause of death in these patients is myocardial stroke and a high incidence of general cardiovascular complications. The purpose of this work was to characterize the genotype of apo E in diabetic patients from Talca, Chile, in order to describe the allelic frequency of the apo E gene and its correlation to the lipids profile. Type 2 diabetic patients (200) were recruited from the Diabetes Program of Talca Hospital, Chile. Apo E genotype was determined by restriction fragment-length polymorphism analysis. A biochemical characterization was performed in all the subjects. Type 2 diabetic patients had elevated levels of glycemia, lipid profile and BMI compared to the control group. The E3/3 genotype and epsilon3 allele had a higher frequency in both groups. The E2/3 and E3/4 genotypes had higher levels of triglyceride (TG) and cholesterol respectively; however, there was not any statistical relationship between them. In conclusion, genotype of apo E in diabetic patients did not differ with healthy; E2/3 and E3/4 genotypes tend to have higher levels of triglyceride and cholesterol respectively. We think that these results corroborate that in the etiology of the dyslipidemia, there is more than one associate genetic marker. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/15936467/Apolipoprotein_E_polymorphism_in_type_2_diabetic_patients_of_Talca_Chile_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(04)00307-9 DB - PRIME DP - Unbound Medicine ER -