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Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia.
Neurosci Lett. 2005 Jul 22-29; 383(1-2):12-6.NL

Abstract

In this study we aimed to evaluate the possibility of using cerebrospinal fluid (CSF) tau, Abeta(1-42) and inflammatory cytokines for diagnosis of Alzheimer's disease (AD) and vascular dementia (VD). We measured levels of total tau (T-tau), phospho-tau (P-tau), Abeta(1-42), IL-6, and TNFalpha in CSF in groups of AD, VD, and controls using enzyme-linked immunosorbent assay (ELISA). T-tau level was found significantly higher in groups of AD (t = 3.015, P < 0.01) and VD (t = 2.872, P < 0.01) than in controls. IL-6 level as also higher in AD (t = 2.883, P < 0.01) and VD (t = 3.032, P < 0.01) than in controls. Both T-tau and IL-6 were not significantly different between AD and VD (P > 0.05). The group of AD had remarkably higher P-tau (t = 4.261 and 3.883, respectively, P < 0.01) and lower Abeta(1-42) (t = 3.883 and 4.129, respectively, P < 0.01), as compared with those in VD and controls. TNFalpha level in AD was significantly higher than that in controls (t = 2.745, P < 0.01), but lower than in VD (t = 3.032, P < 0.01). Our data suggested that increment of T-tau and IL-6 levels in CSF was useful for screening AD and VD in certain population, while descending Abeta(1-42) and ascending TNFalpha in CSF are preferable to diagnose AD. In addition, a higher level of CSF P-tau might support AD diagnosis.

Authors+Show Affiliations

Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China. jjpneuro@public3.bta.net.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15936505

Citation

Jia, J P., et al. "Cerebrospinal Fluid Tau, Abeta1-42 and Inflammatory Cytokines in Patients With Alzheimer's Disease and Vascular Dementia." Neuroscience Letters, vol. 383, no. 1-2, 2005, pp. 12-6.
Jia JP, Meng R, Sun YX, et al. Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neurosci Lett. 2005;383(1-2):12-6.
Jia, J. P., Meng, R., Sun, Y. X., Sun, W. J., Ji, X. M., & Jia, L. F. (2005). Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neuroscience Letters, 383(1-2), 12-6.
Jia JP, et al. Cerebrospinal Fluid Tau, Abeta1-42 and Inflammatory Cytokines in Patients With Alzheimer's Disease and Vascular Dementia. Neurosci Lett. 2005 Jul 22-29;383(1-2):12-6. PubMed PMID: 15936505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. AU - Jia,J P, AU - Meng,R, AU - Sun,Y X, AU - Sun,W J, AU - Ji,X M, AU - Jia,L F, Y1 - 2005/04/25/ PY - 2005/02/10/received PY - 2005/03/22/revised PY - 2005/03/23/accepted PY - 2005/6/7/pubmed PY - 2005/8/23/medline PY - 2005/6/7/entrez SP - 12 EP - 6 JF - Neuroscience letters JO - Neurosci Lett VL - 383 IS - 1-2 N2 - In this study we aimed to evaluate the possibility of using cerebrospinal fluid (CSF) tau, Abeta(1-42) and inflammatory cytokines for diagnosis of Alzheimer's disease (AD) and vascular dementia (VD). We measured levels of total tau (T-tau), phospho-tau (P-tau), Abeta(1-42), IL-6, and TNFalpha in CSF in groups of AD, VD, and controls using enzyme-linked immunosorbent assay (ELISA). T-tau level was found significantly higher in groups of AD (t = 3.015, P < 0.01) and VD (t = 2.872, P < 0.01) than in controls. IL-6 level as also higher in AD (t = 2.883, P < 0.01) and VD (t = 3.032, P < 0.01) than in controls. Both T-tau and IL-6 were not significantly different between AD and VD (P > 0.05). The group of AD had remarkably higher P-tau (t = 4.261 and 3.883, respectively, P < 0.01) and lower Abeta(1-42) (t = 3.883 and 4.129, respectively, P < 0.01), as compared with those in VD and controls. TNFalpha level in AD was significantly higher than that in controls (t = 2.745, P < 0.01), but lower than in VD (t = 3.032, P < 0.01). Our data suggested that increment of T-tau and IL-6 levels in CSF was useful for screening AD and VD in certain population, while descending Abeta(1-42) and ascending TNFalpha in CSF are preferable to diagnose AD. In addition, a higher level of CSF P-tau might support AD diagnosis. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15936505/Cerebrospinal_fluid_tau_Abeta1_42_and_inflammatory_cytokines_in_patients_with_Alzheimer's_disease_and_vascular_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(05)00357-5 DB - PRIME DP - Unbound Medicine ER -