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Functional neuroanatomy of the endocannabinoid system.
Pharmacol Biochem Behav. 2005 Jun; 81(2):239-47.PB

Abstract

Several components of the endocannabinoid system have been fully characterized. Among them are two types of cannabinoid receptors (termed CB1 and CB2), endogenous ligands for those receptors (referred to as "endocannabinoids"), and specific enzymes responsible for their degradation and inactivation. The study of the distribution and abundance of these elements in the central nervous system has provided the basis for the well-known effects of exogenous (both natural and synthetic) and endogenous cannabinoids. In addition, recent developments also support the idea that the endocannabinoid system plays a critical neuromodulatory role in the central nervous system. For instance, cannabinoid CB1 receptor activation is known to modify the release of several neurotransmitters, such as glutamate and gamma-aminobutyric acid. However, we still lack knowledge on fundamental aspects of the physiological roles of this system. Interestingly, changes in the distribution and activity of some of these components of the endocannabinoid system have been reported under different pathological conditions, suggesting their possible involvement in the pathogenesis of these diseases. As comprehensive excellent reviews have been recently published, the present review will focus only on the most recent advances in the field, considering a new perspective of the endocannabinoid system as composed of both neuronal and glial divisions.

Authors+Show Affiliations

Laboratorio de Apoyo a la Investigación, Fundación Hospital Alcorcón, C/ Budapest 1, Alcorcón, Madrid 28922, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15936805

Citation

Pazos, María Ruth, et al. "Functional Neuroanatomy of the Endocannabinoid System." Pharmacology, Biochemistry, and Behavior, vol. 81, no. 2, 2005, pp. 239-47.
Pazos MR, Núñez E, Benito C, et al. Functional neuroanatomy of the endocannabinoid system. Pharmacol Biochem Behav. 2005;81(2):239-47.
Pazos, M. R., Núñez, E., Benito, C., Tolón, R. M., & Romero, J. (2005). Functional neuroanatomy of the endocannabinoid system. Pharmacology, Biochemistry, and Behavior, 81(2), 239-47.
Pazos MR, et al. Functional Neuroanatomy of the Endocannabinoid System. Pharmacol Biochem Behav. 2005;81(2):239-47. PubMed PMID: 15936805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional neuroanatomy of the endocannabinoid system. AU - Pazos,María Ruth, AU - Núñez,Estefanía, AU - Benito,Cristina, AU - Tolón,Rosa María, AU - Romero,Julián, PY - 2004/10/18/received PY - 2004/12/23/revised PY - 2005/01/16/accepted PY - 2005/6/7/pubmed PY - 2005/9/9/medline PY - 2005/6/7/entrez SP - 239 EP - 47 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 81 IS - 2 N2 - Several components of the endocannabinoid system have been fully characterized. Among them are two types of cannabinoid receptors (termed CB1 and CB2), endogenous ligands for those receptors (referred to as "endocannabinoids"), and specific enzymes responsible for their degradation and inactivation. The study of the distribution and abundance of these elements in the central nervous system has provided the basis for the well-known effects of exogenous (both natural and synthetic) and endogenous cannabinoids. In addition, recent developments also support the idea that the endocannabinoid system plays a critical neuromodulatory role in the central nervous system. For instance, cannabinoid CB1 receptor activation is known to modify the release of several neurotransmitters, such as glutamate and gamma-aminobutyric acid. However, we still lack knowledge on fundamental aspects of the physiological roles of this system. Interestingly, changes in the distribution and activity of some of these components of the endocannabinoid system have been reported under different pathological conditions, suggesting their possible involvement in the pathogenesis of these diseases. As comprehensive excellent reviews have been recently published, the present review will focus only on the most recent advances in the field, considering a new perspective of the endocannabinoid system as composed of both neuronal and glial divisions. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/15936805/Functional_neuroanatomy_of_the_endocannabinoid_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(05)00132-2 DB - PRIME DP - Unbound Medicine ER -