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Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell line.
Virus Res. 2005 Nov; 113(2):89-99.VR

Abstract

Recently we confirmed that latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) accelerates a newly forming active c-Jun/Jun B heterodimer, a transcription factor, but little is known about the target gene regulated by it. In this paper, results indicated that a c-Jun/Jun B heterodimer induced by LMP1 upregulated cyclin D1 promoters activity and expression, on the contrary, downregulated p16, and maladjustment of cyclin D1 and p16 expression accelerated progression of cell cycle. Firstly, we found a c-Jun/Jun B heterodimer regulated synchronously and directly cyclin D1 and p16 in the Tet-on-LMP1-HNE2 cell line, in which LMP1 expression is regulated by Tet-on system. This paper investigated in depth function of the newly forming active c-Jun/Jun B heterodimer, and built new connection between environmental pathogenic factor, signal transduction and cell cycle.

Authors+Show Affiliations

Cancer Research Institute, Xiangya School of Medicine, Central South of University, No. 88 Road Xiangya, Changsha 410078, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15936839

Citation

Song, X, et al. "Latent Membrane Protein 1 Encoded By Epstein-Barr Virus Modulates Directly and Synchronously Cyclin D1 and P16 By Newly Forming a c-Jun/Jun B Heterodimer in Nasopharyngeal Carcinoma Cell Line." Virus Research, vol. 113, no. 2, 2005, pp. 89-99.
Song X, Tao YG, Zeng L, et al. Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell line. Virus Res. 2005;113(2):89-99.
Song, X., Tao, Y. G., Zeng, L., Deng, X. Y., Lee, L. M., Gong, J. P., Wu, Q., & Cao, Y. (2005). Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell line. Virus Research, 113(2), 89-99.
Song X, et al. Latent Membrane Protein 1 Encoded By Epstein-Barr Virus Modulates Directly and Synchronously Cyclin D1 and P16 By Newly Forming a c-Jun/Jun B Heterodimer in Nasopharyngeal Carcinoma Cell Line. Virus Res. 2005;113(2):89-99. PubMed PMID: 15936839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell line. AU - Song,X, AU - Tao,Y G, AU - Zeng,L, AU - Deng,X Y, AU - Lee,L M, AU - Gong,J P, AU - Wu,Q, AU - Cao,Y, PY - 2004/11/22/received PY - 2005/04/20/revised PY - 2005/04/27/accepted PY - 2005/6/7/pubmed PY - 2005/11/8/medline PY - 2005/6/7/entrez SP - 89 EP - 99 JF - Virus research JO - Virus Res VL - 113 IS - 2 N2 - Recently we confirmed that latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) accelerates a newly forming active c-Jun/Jun B heterodimer, a transcription factor, but little is known about the target gene regulated by it. In this paper, results indicated that a c-Jun/Jun B heterodimer induced by LMP1 upregulated cyclin D1 promoters activity and expression, on the contrary, downregulated p16, and maladjustment of cyclin D1 and p16 expression accelerated progression of cell cycle. Firstly, we found a c-Jun/Jun B heterodimer regulated synchronously and directly cyclin D1 and p16 in the Tet-on-LMP1-HNE2 cell line, in which LMP1 expression is regulated by Tet-on system. This paper investigated in depth function of the newly forming active c-Jun/Jun B heterodimer, and built new connection between environmental pathogenic factor, signal transduction and cell cycle. SN - 0168-1702 UR - https://www.unboundmedicine.com/medline/citation/15936839/Latent_membrane_protein_1_encoded_by_Epstein_Barr_virus_modulates_directly_and_synchronously_cyclin_D1_and_p16_by_newly_forming_a_c_Jun/Jun_B_heterodimer_in_nasopharyngeal_carcinoma_cell_line_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(05)00154-1 DB - PRIME DP - Unbound Medicine ER -