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Antioxidant activities of Swertia decussata xanthones.
Nat Prod Res. 2005 Jun; 19(4):347-54.NP

Abstract

The lipid peroxidation inhibitory activities of four hydroxyxanthones, isolated from the whole plant Swertia decussata, were evaluated for the first time. The most promising antioxidant among the xanthones, 1,7,8-trihydroxy-3-methoxyxanthone (swertianine, 4) was also tested for its scavenging potential against DPPH and superoxide radicals. The data clearly revealed good antioxidant activity of the xanthones, especially 4 which also showed strong protection against y-ray induced pBR322 DNA damage. A comparison of the radioprotecting activities of the monomethylated tetrahydroxyxanthone 4 with that of its congener, 1,3,7-trihydroxy-8-methoxyxanthone (5) revealed that the radioprotecting activity was not affected by the position of methylation.

Authors+Show Affiliations

Patro BS
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Chintalwar GJ
No affiliation info available
Chattopadhyay S
No affiliation info available

MeSH

AnimalsAntioxidantsDNA DamageIn Vitro TechniquesLipid PeroxidationRatsSwertiaXanthones

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15938140

Citation

Patro, Birija S., et al. "Antioxidant Activities of Swertia Decussata Xanthones." Natural Product Research, vol. 19, no. 4, 2005, pp. 347-54.
Patro BS, Chintalwar GJ, Chattopadhyay S. Antioxidant activities of Swertia decussata xanthones. Nat Prod Res. 2005;19(4):347-54.
Patro, B. S., Chintalwar, G. J., & Chattopadhyay, S. (2005). Antioxidant activities of Swertia decussata xanthones. Natural Product Research, 19(4), 347-54.
Patro BS, Chintalwar GJ, Chattopadhyay S. Antioxidant Activities of Swertia Decussata Xanthones. Nat Prod Res. 2005;19(4):347-54. PubMed PMID: 15938140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activities of Swertia decussata xanthones. AU - Patro,Birija S, AU - Chintalwar,Gajanan J, AU - Chattopadhyay,Subrata, PY - 2005/6/9/pubmed PY - 2005/9/13/medline PY - 2005/6/9/entrez SP - 347 EP - 54 JF - Natural product research JO - Nat Prod Res VL - 19 IS - 4 N2 - The lipid peroxidation inhibitory activities of four hydroxyxanthones, isolated from the whole plant Swertia decussata, were evaluated for the first time. The most promising antioxidant among the xanthones, 1,7,8-trihydroxy-3-methoxyxanthone (swertianine, 4) was also tested for its scavenging potential against DPPH and superoxide radicals. The data clearly revealed good antioxidant activity of the xanthones, especially 4 which also showed strong protection against y-ray induced pBR322 DNA damage. A comparison of the radioprotecting activities of the monomethylated tetrahydroxyxanthone 4 with that of its congener, 1,3,7-trihydroxy-8-methoxyxanthone (5) revealed that the radioprotecting activity was not affected by the position of methylation. SN - 1478-6419 UR - https://www.unboundmedicine.com/medline/citation/15938140/Antioxidant_activities_of_Swertia_decussata_xanthones_ DB - PRIME DP - Unbound Medicine ER -