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Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype.
Atherosclerosis. 2005 Jul; 181(1):115-24.A

Abstract

We tested the hypothesis that dietary alpha-linolenic acid (ALA) can exert effects on markers of cardiovascular risk similar to that produced by its longer chain counterparts in fish-oil. A dietary intervention study was undertaken to examine the effects of an ALA-enriched diet in 57 men expressing an atherogenic lipoprotein phenotype (ALP). Subjects were randomly assigned to one of three diets enriched either with flaxseed oil (FXO: high ALA, n = 21), sunflower oil (SO: high linoleic acid, n = 17), or SO with fish-oil (SOF n = 19) for 12 weeks, resulting in dietary intake ratios of n-6:n-3 PUFA of 0.5, 27.9 and 5.2, respectively. The relative abundance of ALA and EPA in erythrocyte membranes increased on the FXO diet (p < 0.001), whereas both EPA and DHA increased after fish-oil (p < 0.001). There were significant decreases in total plasma cholesterol within (FXO -12.3%, p = 0.001; SOF -7.6%, p = 0.014; SO -7.3%, p = 0.033) and between diets (p = 0.019), and decreases within diets after 12 weeks for HDL cholesterol on flaxseed oil (FXO -10%, p=0.009), plasma TG (-23%, p < 0.001) and small, dense LDL (-22% p = 0.003) in fish-oil. Membrane DHA levels were inversely associated with the changes in plasma TG (p= 0.001) and small, dense LDL (p<0.05) after fish-oil. In conclusion, fish-oil produced predictable changes in plasma lipids and small, dense LDL (sdLDL) that were not reproduced by the ALA-enriched diet. Membrane DHA levels appeared to be an important determinant of these fish-oil-induced effects.

Authors+Show Affiliations

Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15939062

Citation

Wilkinson, Paul, et al. "Influence of Alpha-linolenic Acid and Fish-oil On Markers of Cardiovascular Risk in Subjects With an Atherogenic Lipoprotein Phenotype." Atherosclerosis, vol. 181, no. 1, 2005, pp. 115-24.
Wilkinson P, Leach C, Ah-Sing EE, et al. Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis. 2005;181(1):115-24.
Wilkinson, P., Leach, C., Ah-Sing, E. E., Hussain, N., Miller, G. J., Millward, D. J., & Griffin, B. A. (2005). Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis, 181(1), 115-24.
Wilkinson P, et al. Influence of Alpha-linolenic Acid and Fish-oil On Markers of Cardiovascular Risk in Subjects With an Atherogenic Lipoprotein Phenotype. Atherosclerosis. 2005;181(1):115-24. PubMed PMID: 15939062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. AU - Wilkinson,Paul, AU - Leach,Clare, AU - Ah-Sing,Eric E, AU - Hussain,Nahed, AU - Miller,George J, AU - Millward,D Joe, AU - Griffin,Bruce A, PY - 2004/06/16/received PY - 2004/12/02/revised PY - 2004/12/07/accepted PY - 2005/6/9/pubmed PY - 2005/10/28/medline PY - 2005/6/9/entrez SP - 115 EP - 24 JF - Atherosclerosis JO - Atherosclerosis VL - 181 IS - 1 N2 - We tested the hypothesis that dietary alpha-linolenic acid (ALA) can exert effects on markers of cardiovascular risk similar to that produced by its longer chain counterparts in fish-oil. A dietary intervention study was undertaken to examine the effects of an ALA-enriched diet in 57 men expressing an atherogenic lipoprotein phenotype (ALP). Subjects were randomly assigned to one of three diets enriched either with flaxseed oil (FXO: high ALA, n = 21), sunflower oil (SO: high linoleic acid, n = 17), or SO with fish-oil (SOF n = 19) for 12 weeks, resulting in dietary intake ratios of n-6:n-3 PUFA of 0.5, 27.9 and 5.2, respectively. The relative abundance of ALA and EPA in erythrocyte membranes increased on the FXO diet (p < 0.001), whereas both EPA and DHA increased after fish-oil (p < 0.001). There were significant decreases in total plasma cholesterol within (FXO -12.3%, p = 0.001; SOF -7.6%, p = 0.014; SO -7.3%, p = 0.033) and between diets (p = 0.019), and decreases within diets after 12 weeks for HDL cholesterol on flaxseed oil (FXO -10%, p=0.009), plasma TG (-23%, p < 0.001) and small, dense LDL (-22% p = 0.003) in fish-oil. Membrane DHA levels were inversely associated with the changes in plasma TG (p= 0.001) and small, dense LDL (p<0.05) after fish-oil. In conclusion, fish-oil produced predictable changes in plasma lipids and small, dense LDL (sdLDL) that were not reproduced by the ALA-enriched diet. Membrane DHA levels appeared to be an important determinant of these fish-oil-induced effects. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/15939062/Influence_of_alpha_linolenic_acid_and_fish_oil_on_markers_of_cardiovascular_risk_in_subjects_with_an_atherogenic_lipoprotein_phenotype_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(05)00012-2 DB - PRIME DP - Unbound Medicine ER -