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Ewing's sarcoma and primitive neuroectodermal family of tumors.
Hematol Oncol Clin North Am. 2005 Jun; 19(3):501-25, vi-vii.HO

Abstract

Ewing's sarcoma (ES) initially was believed to be of perivascular endothelial origin. The Ewing's sarcoma family of tumors (EFT) includes ES of bone (ESB), extraosseous ES (EES), peripheral primitive neuroectodermal tumor of bone (pPNET), and malignant small-cell tumor of the thoracopulmonary region, or Askin's tumor, all of which are now known to be neoplasms of neuroectodermal origin. The degree of neuronal differentiation has been used for histopathologic subclassification of the EFT as classical ES (ESB or EES), which is characterized by minimal evidence of neural differentiation, and pPNET, which displays evidence of neural differentiation by standard microscopy, electron microscopy, or immunohistochemistry. Because the behavior, prognosis, and treatment appear to be similar for all subsets of EFT, this histopathologic subclassification may not be clinically significant, though some debate remains whether neural differentiation predicts for inferior outcome.

Authors+Show Affiliations

Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021-6007, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15939194

Citation

Carvajal, Richard, and Paul Meyers. "Ewing's Sarcoma and Primitive Neuroectodermal Family of Tumors." Hematology/oncology Clinics of North America, vol. 19, no. 3, 2005, pp. 501-25, vi-vii.
Carvajal R, Meyers P. Ewing's sarcoma and primitive neuroectodermal family of tumors. Hematol Oncol Clin North Am. 2005;19(3):501-25, vi-vii.
Carvajal, R., & Meyers, P. (2005). Ewing's sarcoma and primitive neuroectodermal family of tumors. Hematology/oncology Clinics of North America, 19(3), 501-25, vi-vii.
Carvajal R, Meyers P. Ewing's Sarcoma and Primitive Neuroectodermal Family of Tumors. Hematol Oncol Clin North Am. 2005;19(3):501-25, vi-vii. PubMed PMID: 15939194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ewing's sarcoma and primitive neuroectodermal family of tumors. AU - Carvajal,Richard, AU - Meyers,Paul, PY - 2005/6/9/pubmed PY - 2005/8/10/medline PY - 2005/6/9/entrez SP - 501-25, vi-vii JF - Hematology/oncology clinics of North America JO - Hematol. Oncol. Clin. North Am. VL - 19 IS - 3 N2 - Ewing's sarcoma (ES) initially was believed to be of perivascular endothelial origin. The Ewing's sarcoma family of tumors (EFT) includes ES of bone (ESB), extraosseous ES (EES), peripheral primitive neuroectodermal tumor of bone (pPNET), and malignant small-cell tumor of the thoracopulmonary region, or Askin's tumor, all of which are now known to be neoplasms of neuroectodermal origin. The degree of neuronal differentiation has been used for histopathologic subclassification of the EFT as classical ES (ESB or EES), which is characterized by minimal evidence of neural differentiation, and pPNET, which displays evidence of neural differentiation by standard microscopy, electron microscopy, or immunohistochemistry. Because the behavior, prognosis, and treatment appear to be similar for all subsets of EFT, this histopathologic subclassification may not be clinically significant, though some debate remains whether neural differentiation predicts for inferior outcome. SN - 0889-8588 UR - https://www.unboundmedicine.com/medline/citation/15939194/Ewing's_sarcoma_and_primitive_neuroectodermal_family_of_tumors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8588(05)00031-6 DB - PRIME DP - Unbound Medicine ER -