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Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations.
J Neurosci Methods. 2005 Oct 15; 148(1):78-87.JN

Abstract

This study compares histological, neurochemical, behavioral, motor and cognitive alterations as well as mortality of two models of Parkinson's disease in which 100 microg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6 microg 6-hydroxydopamine (6-OHDA) was bilaterally infused into the central region of the substantia nigra, compact part, of adult male Wistar rats. Both neurotoxins caused a significant loss of nigral tyrosine hydroxylase-immunostained cells and striatal dopamine depletion, but 6-OHDA caused more widespread and intense cell loss, more intense body weight loss and more mortality than MPTP. Both 6-OHDA- and MPTP-lesioned rats presented similar deficits in performing a working memory and a cued version of the Morris water maze task and few exploratory/motor alterations in the open field and catalepsy tests. However, rats presented a significant and transitory increase in locomotor activity after the MPTP lesion and a hypolocomotor behavior tended to be present after the 6-OHDA lesion. The picture of mild motor effects and robust impairment of habit learning and spatial working memory observed in MPTP-lesioned rats models the early phase of Parkinson's disease.

Authors+Show Affiliations

Ferro MM
Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, Brazil.
Bellissimo MI
No affiliation info available
Anselmo-Franci JA
No affiliation info available
Angellucci ME
No affiliation info available
Canteras NS
No affiliation info available
Da Cunha C
No affiliation info available

MeSH

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAdrenergic AgentsAnalysis of VarianceAnimalsBrain ChemistryDisease Models, AnimalMaleMemoryMotor ActivityOxidopamineParkinsonian DisordersRatsRats, WistarSubstantia NigraTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15939479

Citation

Ferro, Marcelo Machado, et al. "Comparison of Bilaterally 6-OHDA- and MPTP-lesioned Rats as Models of the Early Phase of Parkinson's Disease: Histological, Neurochemical, Motor and Memory Alterations." Journal of Neuroscience Methods, vol. 148, no. 1, 2005, pp. 78-87.
Ferro MM, Bellissimo MI, Anselmo-Franci JA, et al. Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations. J Neurosci Methods. 2005;148(1):78-87.
Ferro, M. M., Bellissimo, M. I., Anselmo-Franci, J. A., Angellucci, M. E., Canteras, N. S., & Da Cunha, C. (2005). Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations. Journal of Neuroscience Methods, 148(1), 78-87.
Ferro MM, et al. Comparison of Bilaterally 6-OHDA- and MPTP-lesioned Rats as Models of the Early Phase of Parkinson's Disease: Histological, Neurochemical, Motor and Memory Alterations. J Neurosci Methods. 2005 Oct 15;148(1):78-87. PubMed PMID: 15939479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations. AU - Ferro,Marcelo Machado, AU - Bellissimo,Maria Ines, AU - Anselmo-Franci,Janete Aparecida, AU - Angellucci,Miriam Elizabeth Mendes, AU - Canteras,Newton Sabino, AU - Da Cunha,Claudio, Y1 - 2005/06/06/ PY - 2004/11/18/received PY - 2005/04/04/revised PY - 2005/04/12/accepted PY - 2005/6/9/pubmed PY - 2006/1/21/medline PY - 2005/6/9/entrez SP - 78 EP - 87 JF - Journal of neuroscience methods JO - J Neurosci Methods VL - 148 IS - 1 N2 - This study compares histological, neurochemical, behavioral, motor and cognitive alterations as well as mortality of two models of Parkinson's disease in which 100 microg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6 microg 6-hydroxydopamine (6-OHDA) was bilaterally infused into the central region of the substantia nigra, compact part, of adult male Wistar rats. Both neurotoxins caused a significant loss of nigral tyrosine hydroxylase-immunostained cells and striatal dopamine depletion, but 6-OHDA caused more widespread and intense cell loss, more intense body weight loss and more mortality than MPTP. Both 6-OHDA- and MPTP-lesioned rats presented similar deficits in performing a working memory and a cued version of the Morris water maze task and few exploratory/motor alterations in the open field and catalepsy tests. However, rats presented a significant and transitory increase in locomotor activity after the MPTP lesion and a hypolocomotor behavior tended to be present after the 6-OHDA lesion. The picture of mild motor effects and robust impairment of habit learning and spatial working memory observed in MPTP-lesioned rats models the early phase of Parkinson's disease. SN - 0165-0270 UR - https://www.unboundmedicine.com/medline/citation/15939479/Comparison_of_bilaterally_6_OHDA__and_MPTP_lesioned_rats_as_models_of_the_early_phase_of_Parkinson's_disease:_histological_neurochemical_motor_and_memory_alterations_ DB - PRIME DP - Unbound Medicine ER -