Tags

Type your tag names separated by a space and hit enter

The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus.
Vaccine. 2005 Sep 15; 23(39):4785-92.V

Abstract

Seven volunteers involved in flavivirus studies have been immunized with commercial Japanese encephalitis and yellow fever vaccines JE-VAX and YF-VAX. Strong homologous and cross-reactive with West Nile virus (WNV) antibody responses with titers 1:1600 to 1:51200 were found in all donors. All donors developed high levels of yellow fever virus (YFV) and Japanese encephalitis virus (JEV) neutralizing antibodies with titers 1:50 to 1:1600 and 1:20 to 1:640, respectively, and WNV neutralizing antibodies with titers 1:10 to 1:80. In contrast, predominantly YF-specific cell-mediated immunity was detected in all immunized donors. Responses to YFV were long lasting, but the anti-JEV humoral immunity was found to decrease with time. Cross-reactive anti-WNV responses were following the same trend dropping below detectable level at 4 years post-immunization and sharply coming back after booster immunization with the JE vaccine. Thus, immunization with the commercial flavivirus JE vaccine may be beneficial for individuals at high risk of exposure to WNV, such as personnel involved in WN research.

Authors+Show Affiliations

Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside ave, Lawrence, KS 66045, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15939510

Citation

Yamshchikov, Galina, et al. "The Suitability of Yellow Fever and Japanese Encephalitis Vaccines for Immunization Against West Nile Virus." Vaccine, vol. 23, no. 39, 2005, pp. 4785-92.
Yamshchikov G, Borisevich V, Kwok CW, et al. The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus. Vaccine. 2005;23(39):4785-92.
Yamshchikov, G., Borisevich, V., Kwok, C. W., Nistler, R., Kohlmeier, J., Seregin, A., Chaporgina, E., Benedict, S., & Yamshchikov, V. (2005). The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus. Vaccine, 23(39), 4785-92.
Yamshchikov G, et al. The Suitability of Yellow Fever and Japanese Encephalitis Vaccines for Immunization Against West Nile Virus. Vaccine. 2005 Sep 15;23(39):4785-92. PubMed PMID: 15939510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus. AU - Yamshchikov,Galina, AU - Borisevich,Victoria, AU - Kwok,Chun Wai, AU - Nistler,Ryan, AU - Kohlmeier,Jake, AU - Seregin,Alexey, AU - Chaporgina,Elena, AU - Benedict,Stephen, AU - Yamshchikov,Vladimir, PY - 2005/02/08/received PY - 2005/04/18/revised PY - 2005/04/19/accepted PY - 2005/6/9/pubmed PY - 2005/9/30/medline PY - 2005/6/9/entrez SP - 4785 EP - 92 JF - Vaccine JO - Vaccine VL - 23 IS - 39 N2 - Seven volunteers involved in flavivirus studies have been immunized with commercial Japanese encephalitis and yellow fever vaccines JE-VAX and YF-VAX. Strong homologous and cross-reactive with West Nile virus (WNV) antibody responses with titers 1:1600 to 1:51200 were found in all donors. All donors developed high levels of yellow fever virus (YFV) and Japanese encephalitis virus (JEV) neutralizing antibodies with titers 1:50 to 1:1600 and 1:20 to 1:640, respectively, and WNV neutralizing antibodies with titers 1:10 to 1:80. In contrast, predominantly YF-specific cell-mediated immunity was detected in all immunized donors. Responses to YFV were long lasting, but the anti-JEV humoral immunity was found to decrease with time. Cross-reactive anti-WNV responses were following the same trend dropping below detectable level at 4 years post-immunization and sharply coming back after booster immunization with the JE vaccine. Thus, immunization with the commercial flavivirus JE vaccine may be beneficial for individuals at high risk of exposure to WNV, such as personnel involved in WN research. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/15939510/The_suitability_of_yellow_fever_and_Japanese_encephalitis_vaccines_for_immunization_against_West_Nile_virus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(05)00498-6 DB - PRIME DP - Unbound Medicine ER -