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Postmenopausal hormone therapy and mammographic breast density.
Maturitas. 2006 Jan 10; 53(1):59-64.M

Abstract

OBJECTIVE

The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density.

MATERIALS AND METHODS

In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die plus medroxyprogesterone acetate (MPA) 5mg/die or placebo. Mammograms were performed at baseline and after 12 months of treatment. Mammographic density was quantified according to the Wolfe classification.

RESULTS

After 12 months of HRT 16 of the 35 patients (45.1%) receiving continuous combined hormonal therapy showed an increase of breast density change in the Wolfe classification. After treatment with tibolone, an up grading in breast density, according to Wolfe's classification, was found in 2 of the 43 patients (2.3%). No changes were recorded in the 25 patients of the control group. The difference between the group treated with continuous combined hormonal therapy and the control group was highly significant (p<0.001). The difference in breast density between patients in treatment with tibolone and the control group was not statistically significant (p=0.34).

DISCUSSION

Continuous combination HRT may be more commonly associated with an increase of mammography density than tibolone treatment.

Authors+Show Affiliations

Department of Surgical Sciences, Chair of Obstetrics and Gynecology, University of Udine, P.le Santa Maria della Misericordia, 33100 Udine, Italy. diego.marchesoni@dsc.uniud.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15939560

Citation

Marchesoni, D, et al. "Postmenopausal Hormone Therapy and Mammographic Breast Density." Maturitas, vol. 53, no. 1, 2006, pp. 59-64.
Marchesoni D, Driul L, Ianni A, et al. Postmenopausal hormone therapy and mammographic breast density. Maturitas. 2006;53(1):59-64.
Marchesoni, D., Driul, L., Ianni, A., Fabiani, G., Della Martina, M., Zuiani, C., & Bazzocchi, M. (2006). Postmenopausal hormone therapy and mammographic breast density. Maturitas, 53(1), 59-64.
Marchesoni D, et al. Postmenopausal Hormone Therapy and Mammographic Breast Density. Maturitas. 2006 Jan 10;53(1):59-64. PubMed PMID: 15939560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postmenopausal hormone therapy and mammographic breast density. AU - Marchesoni,D, AU - Driul,L, AU - Ianni,A, AU - Fabiani,G, AU - Della Martina,M, AU - Zuiani,C, AU - Bazzocchi,M, Y1 - 2005/06/06/ PY - 2004/10/28/received PY - 2005/02/06/revised PY - 2005/02/09/accepted PY - 2005/6/9/pubmed PY - 2007/3/27/medline PY - 2005/6/9/entrez SP - 59 EP - 64 JF - Maturitas JO - Maturitas VL - 53 IS - 1 N2 - OBJECTIVE: The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density. MATERIALS AND METHODS: In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die plus medroxyprogesterone acetate (MPA) 5mg/die or placebo. Mammograms were performed at baseline and after 12 months of treatment. Mammographic density was quantified according to the Wolfe classification. RESULTS: After 12 months of HRT 16 of the 35 patients (45.1%) receiving continuous combined hormonal therapy showed an increase of breast density change in the Wolfe classification. After treatment with tibolone, an up grading in breast density, according to Wolfe's classification, was found in 2 of the 43 patients (2.3%). No changes were recorded in the 25 patients of the control group. The difference between the group treated with continuous combined hormonal therapy and the control group was highly significant (p<0.001). The difference in breast density between patients in treatment with tibolone and the control group was not statistically significant (p=0.34). DISCUSSION: Continuous combination HRT may be more commonly associated with an increase of mammography density than tibolone treatment. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/15939560/Postmenopausal_hormone_therapy_and_mammographic_breast_density_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(05)00028-9 DB - PRIME DP - Unbound Medicine ER -