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Antibiotic exposure in early infancy and risk for childhood atopy.
J Allergy Clin Immunol. 2005 Jun; 115(6):1218-24.JA

Abstract

BACKGROUND

The increase in pediatric allergy and asthma parallels the increase in use of antibiotics. Antibiotics disturb the flora of the gastrointestinal tract, possibly perturbing the developing immune system.

OBJECTIVE

We evaluated whether antibiotic use during early infancy increased the risk for atopy.

METHODS

Antibiotic prescriptions documented in medical records were collected from a birth cohort born from 1987 through 1989 (n = 725). At 6 to 7 years of age, 448 were followed by means of examination, including skin prick tests and serum IgE measurements to common allergens.

RESULTS

Adjusted odds ratios (aORs) and 95% CIs were calculated comparing children with any versus those with no antibiotic use in the first 6 months and the outcomes of atopy (any positive skin test response), seroatopy (any positive specific IgE test result), either atopy or seroatopy, and both atopy and seroatopy. Atopy increased with antibiotic use approaching statistical significance (aOR, 1.48; 95% CI, 0.94-2.34; P = .09); however, the risk was concentrated among children with less than 2 pets in the home (aOR, 1.73; 95% CI, 1.07-2.80; P = .024) and children breast-fed for 4 or more months (aOR, 3.02; 95% CI, 1.27-7.17; P = .013). The aORs were generally in the same direction for seroatopy and the combined categories.

CONCLUSION

Antibiotic use in early life appears to contribute to increased risk for atopy in certain subgroups of children.

Authors+Show Affiliations

Department of Biostatistics and Research Epidemiology, Henry Ford Health System, 1 Ford Place 5C, Detroit, MI 48202, USA. cjohnso1@hfhs.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15940137

Citation

Johnson, Christine Cole, et al. "Antibiotic Exposure in Early Infancy and Risk for Childhood Atopy." The Journal of Allergy and Clinical Immunology, vol. 115, no. 6, 2005, pp. 1218-24.
Johnson CC, Ownby DR, Alford SH, et al. Antibiotic exposure in early infancy and risk for childhood atopy. J Allergy Clin Immunol. 2005;115(6):1218-24.
Johnson, C. C., Ownby, D. R., Alford, S. H., Havstad, S. L., Williams, L. K., Zoratti, E. M., Peterson, E. L., & Joseph, C. L. (2005). Antibiotic exposure in early infancy and risk for childhood atopy. The Journal of Allergy and Clinical Immunology, 115(6), 1218-24.
Johnson CC, et al. Antibiotic Exposure in Early Infancy and Risk for Childhood Atopy. J Allergy Clin Immunol. 2005;115(6):1218-24. PubMed PMID: 15940137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic exposure in early infancy and risk for childhood atopy. AU - Johnson,Christine Cole, AU - Ownby,Dennis R, AU - Alford,Sharon Hensley, AU - Havstad,Suzanne L, AU - Williams,L Keoki, AU - Zoratti,Edward M, AU - Peterson,Edward L, AU - Joseph,Christine L M, PY - 2005/6/9/pubmed PY - 2005/8/3/medline PY - 2005/6/9/entrez SP - 1218 EP - 24 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 115 IS - 6 N2 - BACKGROUND: The increase in pediatric allergy and asthma parallels the increase in use of antibiotics. Antibiotics disturb the flora of the gastrointestinal tract, possibly perturbing the developing immune system. OBJECTIVE: We evaluated whether antibiotic use during early infancy increased the risk for atopy. METHODS: Antibiotic prescriptions documented in medical records were collected from a birth cohort born from 1987 through 1989 (n = 725). At 6 to 7 years of age, 448 were followed by means of examination, including skin prick tests and serum IgE measurements to common allergens. RESULTS: Adjusted odds ratios (aORs) and 95% CIs were calculated comparing children with any versus those with no antibiotic use in the first 6 months and the outcomes of atopy (any positive skin test response), seroatopy (any positive specific IgE test result), either atopy or seroatopy, and both atopy and seroatopy. Atopy increased with antibiotic use approaching statistical significance (aOR, 1.48; 95% CI, 0.94-2.34; P = .09); however, the risk was concentrated among children with less than 2 pets in the home (aOR, 1.73; 95% CI, 1.07-2.80; P = .024) and children breast-fed for 4 or more months (aOR, 3.02; 95% CI, 1.27-7.17; P = .013). The aORs were generally in the same direction for seroatopy and the combined categories. CONCLUSION: Antibiotic use in early life appears to contribute to increased risk for atopy in certain subgroups of children. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15940137/Antibiotic_exposure_in_early_infancy_and_risk_for_childhood_atopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674905007633 DB - PRIME DP - Unbound Medicine ER -