Tags

Type your tag names separated by a space and hit enter

Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome.

Abstract

BACKGROUND

The immunomodulating mechanisms of Lactobacillus GG (LGG) and other probiotics are poorly understood.

OBJECTIVE

We studied in vivo the immunologic effects of probiotics in infants with atopic eczema-dermatitis syndrome (AEDS) and cow's milk allergy (CMA).

METHODS

Two hundred thirty infants with AEDS and suspected CMA received, concomitant with elimination diet, either LGG, a mixture of 4 probiotic strains (MIX), or placebo for 4 weeks. All available paired pretreatment and posttreatment plasma samples (n = 132) were analyzed for concentrations of IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma, soluble intercellular adhesion molecule 1, soluble E-selectin, TGF-beta1, TGF-beta2, and C-reactive protein.

RESULTS

In infants with IgE-associated AEDS, treatment with LGG induced higher C-reactive protein levels than in the placebo group (geometric mean, 0.83 microg/mL [95% CI, 0.56-0.81] vs 0.42 microg/mL [95% CI, 0.27-0.65]; P = .021). Concomitantly, IL-6 levels increased after treatment with LGG ( P = .023) but not with MIX or placebo. Soluble E-selectin levels were higher after probiotic than after placebo treatment in infants with IgE-mediated CMA (LGG geometric mean, 86.7 ng/mL [95% CI, 75.2-100]; MIX geometric mean, 91.6 ng/mL [95% CI, 74.8-111.9]; and placebo geometric mean, 64.9 ng/mL [95% CI, 53-79.3]; analysis of covariance, P = .035; LGG vs placebo, P = .023; MIX vs placebo, P = .020). Use of MIX induced an increase in plasma IL-10 levels ( P = .016).

CONCLUSION

Probiotics induced systemically detectable low-grade inflammation, which might explain the clinical effects of probiotics in AEDS and CMA.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Skin and Allergy Hospital, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland. mirva.viljanen@hus.fi

    , , , , , ,

    Source

    MeSH

    Animals
    C-Reactive Protein
    Dermatitis, Atopic
    Double-Blind Method
    E-Selectin
    Female
    Humans
    Infant
    Inflammation Mediators
    Interleukin-6
    Lactobacillus
    Male
    Milk Hypersensitivity
    Probiotics

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15940143

    Citation

    Viljanen, Mirva, et al. "Induction of Inflammation as a Possible Mechanism of Probiotic Effect in Atopic Eczema-dermatitis Syndrome." The Journal of Allergy and Clinical Immunology, vol. 115, no. 6, 2005, pp. 1254-9.
    Viljanen M, Pohjavuori E, Haahtela T, et al. Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome. J Allergy Clin Immunol. 2005;115(6):1254-9.
    Viljanen, M., Pohjavuori, E., Haahtela, T., Korpela, R., Kuitunen, M., Sarnesto, A., ... Savilahti, E. (2005). Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome. The Journal of Allergy and Clinical Immunology, 115(6), pp. 1254-9.
    Viljanen M, et al. Induction of Inflammation as a Possible Mechanism of Probiotic Effect in Atopic Eczema-dermatitis Syndrome. J Allergy Clin Immunol. 2005;115(6):1254-9. PubMed PMID: 15940143.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome. AU - Viljanen,Mirva, AU - Pohjavuori,Emma, AU - Haahtela,Tari, AU - Korpela,Riitta, AU - Kuitunen,Mikael, AU - Sarnesto,Annikki, AU - Vaarala,Outi, AU - Savilahti,Erkki, PY - 2005/6/9/pubmed PY - 2005/8/3/medline PY - 2005/6/9/entrez SP - 1254 EP - 9 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 115 IS - 6 N2 - BACKGROUND: The immunomodulating mechanisms of Lactobacillus GG (LGG) and other probiotics are poorly understood. OBJECTIVE: We studied in vivo the immunologic effects of probiotics in infants with atopic eczema-dermatitis syndrome (AEDS) and cow's milk allergy (CMA). METHODS: Two hundred thirty infants with AEDS and suspected CMA received, concomitant with elimination diet, either LGG, a mixture of 4 probiotic strains (MIX), or placebo for 4 weeks. All available paired pretreatment and posttreatment plasma samples (n = 132) were analyzed for concentrations of IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma, soluble intercellular adhesion molecule 1, soluble E-selectin, TGF-beta1, TGF-beta2, and C-reactive protein. RESULTS: In infants with IgE-associated AEDS, treatment with LGG induced higher C-reactive protein levels than in the placebo group (geometric mean, 0.83 microg/mL [95% CI, 0.56-0.81] vs 0.42 microg/mL [95% CI, 0.27-0.65]; P = .021). Concomitantly, IL-6 levels increased after treatment with LGG ( P = .023) but not with MIX or placebo. Soluble E-selectin levels were higher after probiotic than after placebo treatment in infants with IgE-mediated CMA (LGG geometric mean, 86.7 ng/mL [95% CI, 75.2-100]; MIX geometric mean, 91.6 ng/mL [95% CI, 74.8-111.9]; and placebo geometric mean, 64.9 ng/mL [95% CI, 53-79.3]; analysis of covariance, P = .035; LGG vs placebo, P = .023; MIX vs placebo, P = .020). Use of MIX induced an increase in plasma IL-10 levels ( P = .016). CONCLUSION: Probiotics induced systemically detectable low-grade inflammation, which might explain the clinical effects of probiotics in AEDS and CMA. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15940143/Induction_of_inflammation_as_a_possible_mechanism_of_probiotic_effect_in_atopic_eczema_dermatitis_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674905007189 DB - PRIME DP - Unbound Medicine ER -