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[Research on Parvovirus B19 infections and chronic articular manifestations in a Tunisian hospital].
Arch Inst Pasteur Tunis. 2003; 80(1-4):9-15.AI

Abstract

Parvovirus B19 infection is often associated with acute and chronic joint diseases thus suggesting an etiologic role for the virus in these pathologies. In this work, we looked for a possible correlation between Parvovirus B19 infection and certain types of chronic inflammatory rheumatisms. We therefore, screened a population of 100 patients with different chronic inflammatory rheumatismal affections for serological markers of Parvovirus B19 infection. All patients were Tunisians of both sexes, who presented at the service of Rheumatology of the Charles Nicolle Hospital, Tunis. One hundred blood donors were taken as controls. Specific Immunoenzyme Assays of the ELISA type (Biotrin International, France) were used to detect anti-Parvovirus IgG and IgM. On the other hand, viral DNA was sought by nested PCR in synovial fluid from 14 patients. The data obtained indicate that specific anti-Parvovirus B19 IgG was detectable in the sera of 80.7% of patients and 43% of controls. In contrast, none of the sera was found positive for specific IgM antibodies. Synovial fluid samples could be collected from 14 anti-Parvovirus B19 seropositive patients and were tested for the presence of viral DNA. None of the samples was found positive. The results of our serological study reinforce the hypothesis that Parvovirus B19 infection is associated with rheumatismal joint affections. However, the lack of detectable viral DNA in synovial fluid of the tested seropositive patients points to an indirect role of the virus in these joint disorders.

Authors+Show Affiliations

Banque du sang, Hôpital Charles Nicolle a Tunis.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

15941063

Citation

Regaya, F, et al. "[Research On Parvovirus B19 Infections and Chronic Articular Manifestations in a Tunisian Hospital]." Archives De l'Institut Pasteur De Tunis, vol. 80, no. 1-4, 2003, pp. 9-15.
Regaya F, Khelifa R, Zouari R, et al. [Research on Parvovirus B19 infections and chronic articular manifestations in a Tunisian hospital]. Arch Inst Pasteur Tunis. 2003;80(1-4):9-15.
Regaya, F., Khelifa, R., Zouari, R., Kchir, M., Karoui, M., & Essid, R. (2003). [Research on Parvovirus B19 infections and chronic articular manifestations in a Tunisian hospital]. Archives De l'Institut Pasteur De Tunis, 80(1-4), 9-15.
Regaya F, et al. [Research On Parvovirus B19 Infections and Chronic Articular Manifestations in a Tunisian Hospital]. Arch Inst Pasteur Tunis. 2003;80(1-4):9-15. PubMed PMID: 15941063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Research on Parvovirus B19 infections and chronic articular manifestations in a Tunisian hospital]. AU - Regaya,F, AU - Khelifa,R, AU - Zouari,R, AU - Kchir,M, AU - Karoui,M, AU - Essid,R, PY - 2005/6/9/pubmed PY - 2005/6/24/medline PY - 2005/6/9/entrez SP - 9 EP - 15 JF - Archives de l'Institut Pasteur de Tunis JO - Arch Inst Pasteur Tunis VL - 80 IS - 1-4 N2 - Parvovirus B19 infection is often associated with acute and chronic joint diseases thus suggesting an etiologic role for the virus in these pathologies. In this work, we looked for a possible correlation between Parvovirus B19 infection and certain types of chronic inflammatory rheumatisms. We therefore, screened a population of 100 patients with different chronic inflammatory rheumatismal affections for serological markers of Parvovirus B19 infection. All patients were Tunisians of both sexes, who presented at the service of Rheumatology of the Charles Nicolle Hospital, Tunis. One hundred blood donors were taken as controls. Specific Immunoenzyme Assays of the ELISA type (Biotrin International, France) were used to detect anti-Parvovirus IgG and IgM. On the other hand, viral DNA was sought by nested PCR in synovial fluid from 14 patients. The data obtained indicate that specific anti-Parvovirus B19 IgG was detectable in the sera of 80.7% of patients and 43% of controls. In contrast, none of the sera was found positive for specific IgM antibodies. Synovial fluid samples could be collected from 14 anti-Parvovirus B19 seropositive patients and were tested for the presence of viral DNA. None of the samples was found positive. The results of our serological study reinforce the hypothesis that Parvovirus B19 infection is associated with rheumatismal joint affections. However, the lack of detectable viral DNA in synovial fluid of the tested seropositive patients points to an indirect role of the virus in these joint disorders. SN - 0020-2509 UR - https://www.unboundmedicine.com/medline/citation/15941063/[Research_on_Parvovirus_B19_infections_and_chronic_articular_manifestations_in_a_Tunisian_hospital]_ L2 - https://medlineplus.gov/infectiousarthritis.html DB - PRIME DP - Unbound Medicine ER -