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Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells.
J Agric Food Chem. 2005 Jun 15; 53(12):4728-35.JA

Abstract

Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS(*+), DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection.

Authors+Show Affiliations

Institute for Chemical and Environmental Research (IIQAB-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15941307

Citation

Touriño, Sonia, et al. "Procyanidin Fractions From Pine (Pinus Pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells." Journal of Agricultural and Food Chemistry, vol. 53, no. 12, 2005, pp. 4728-35.
Touriño S, Selga A, Jiménez A, et al. Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells. J Agric Food Chem. 2005;53(12):4728-35.
Touriño, S., Selga, A., Jiménez, A., Juliá, L., Lozano, C., Lizárraga, D., Cascante, M., & Torres, J. L. (2005). Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells. Journal of Agricultural and Food Chemistry, 53(12), 4728-35.
Touriño S, et al. Procyanidin Fractions From Pine (Pinus Pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells. J Agric Food Chem. 2005 Jun 15;53(12):4728-35. PubMed PMID: 15941307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells. AU - Touriño,Sonia, AU - Selga,Ariadna, AU - Jiménez,Aurora, AU - Juliá,Lluís, AU - Lozano,Carles, AU - Lizárraga,Daneida, AU - Cascante,Marta, AU - Torres,Josep Lluís, PY - 2005/6/9/pubmed PY - 2005/8/18/medline PY - 2005/6/9/entrez SP - 4728 EP - 35 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 53 IS - 12 N2 - Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS(*+), DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15941307/Procyanidin_fractions_from_pine__Pinus_pinaster__bark:_radical_scavenging_power_in_solution_antioxidant_activity_in_emulsion_and_antiproliferative_effect_in_melanoma_cells_ L2 - https://doi.org/10.1021/jf050262q DB - PRIME DP - Unbound Medicine ER -