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Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali.
Trop Med Int Health. 2005 Jun; 10(6):550-6.TM

Abstract

BACKGROUND

Modelling malaria parasitaemia as function of fever has been proposed as best alternative to estimate the attributable fraction of malaria fever and the sensitivity and specificity of different case definitions of malaria disease.

OBJECTIVES

To determine the prevalence of fever and its relation to malaria parasitaemia and to establish a pyrogenic threshold for malaria disease in the area.

METHODS

We conducted two cross-sectional surveys in children of 6 months to 9 years of age (2434 during the rainy season of 1993 and 2353 during the dry season of 1994) randomly selected from 21 areas of Bandiagara district, Mali.

RESULTS

The relationship between fever and Plasmodium falciparum parasitaemia depends strongly on the season, thus affecting the malaria-attributable fraction of fever cases and the sensitivity and specificity of malaria case definitions. The overall proportion of fever attributable to malaria parasitaemia was 33.6% during the rainy season and 23.3% during the dry season, with the highest proportion occurring among the youngest children. The cut-off value, where the sensitivity curve crosses the specificity curve, was around 3200 pf/microl for all age categories during the rainy season and 200 pf/microl during the dry season.

CONCLUSIONS

Malaria remains a main cause of fever in this area of Mali. The pyrogenic threshold of parasitaemia depends strongly on the season, and different cut-off levels of parasitaemia should be used during the two seasons to define malaria cases in this area.

Authors+Show Affiliations

Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-stomatology, University of Bamako, Bamako, Mali. adicko@mrtcbko.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15941418

Citation

Dicko, Alassane, et al. "Season, Fever Prevalence and Pyrogenic Threshold for Malaria Disease Definition in an Endemic Area of Mali." Tropical Medicine & International Health : TM & IH, vol. 10, no. 6, 2005, pp. 550-6.
Dicko A, Mantel C, Kouriba B, et al. Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali. Trop Med Int Health. 2005;10(6):550-6.
Dicko, A., Mantel, C., Kouriba, B., Sagara, I., Thera, M. A., Doumbia, S., Diallo, M., Poudiougou, B., Diakite, M., & Doumbo, O. K. (2005). Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali. Tropical Medicine & International Health : TM & IH, 10(6), 550-6.
Dicko A, et al. Season, Fever Prevalence and Pyrogenic Threshold for Malaria Disease Definition in an Endemic Area of Mali. Trop Med Int Health. 2005;10(6):550-6. PubMed PMID: 15941418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali. AU - Dicko,Alassane, AU - Mantel,Carsten, AU - Kouriba,Boureima, AU - Sagara,Issaka, AU - Thera,Mahamadou A, AU - Doumbia,Seydou, AU - Diallo,Mouctar, AU - Poudiougou,Belco, AU - Diakite,Mahamadou, AU - Doumbo,Ogobara K, PY - 2005/6/9/pubmed PY - 2005/6/29/medline PY - 2005/6/9/entrez SP - 550 EP - 6 JF - Tropical medicine & international health : TM & IH JO - Trop Med Int Health VL - 10 IS - 6 N2 - BACKGROUND: Modelling malaria parasitaemia as function of fever has been proposed as best alternative to estimate the attributable fraction of malaria fever and the sensitivity and specificity of different case definitions of malaria disease. OBJECTIVES: To determine the prevalence of fever and its relation to malaria parasitaemia and to establish a pyrogenic threshold for malaria disease in the area. METHODS: We conducted two cross-sectional surveys in children of 6 months to 9 years of age (2434 during the rainy season of 1993 and 2353 during the dry season of 1994) randomly selected from 21 areas of Bandiagara district, Mali. RESULTS: The relationship between fever and Plasmodium falciparum parasitaemia depends strongly on the season, thus affecting the malaria-attributable fraction of fever cases and the sensitivity and specificity of malaria case definitions. The overall proportion of fever attributable to malaria parasitaemia was 33.6% during the rainy season and 23.3% during the dry season, with the highest proportion occurring among the youngest children. The cut-off value, where the sensitivity curve crosses the specificity curve, was around 3200 pf/microl for all age categories during the rainy season and 200 pf/microl during the dry season. CONCLUSIONS: Malaria remains a main cause of fever in this area of Mali. The pyrogenic threshold of parasitaemia depends strongly on the season, and different cut-off levels of parasitaemia should be used during the two seasons to define malaria cases in this area. SN - 1360-2276 UR - https://www.unboundmedicine.com/medline/citation/15941418/Season_fever_prevalence_and_pyrogenic_threshold_for_malaria_disease_definition_in_an_endemic_area_of_Mali_ L2 - https://doi.org/10.1111/j.1365-3156.2005.01418.x DB - PRIME DP - Unbound Medicine ER -