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[Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming].
Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Apr; 26(4):286-9.ZL

Abstract

OBJECTIVE

To explore the immunogenetic features of human leukocyte antigen DRB1, DQB1 locus and children with Helicobacter pylori (H. pylori) infection in Han ethnic population in Kunming and its association with digestive diseases and H. pylori to better understand the immunogenetic features of the H. pylori infection.

METHODS

Polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to study the HLA-DRB1, DQB1 allelic frequency distribution on 35 children with H. pylori infection and 37 healthy controls in Han ethnic population in Kunming.

RESULTS

Allelic frequencies of HLA-DRB1 * 0901, DQB1 * 03032 in the H. pylori infection group were lower than those of the healthy control group (7.14% vs. 31.08%, chi(2) = 13.16, Pc < 0.012; 5.71% vs. 25.68%, chi(2) = 10.68, Pc = 0.007) but the rest alleles' frequencies did not show significant differences.

CONCLUSION

These result suggested that HLA-DRB1 * 0901, DQB1 * 03032 might protect the H. pylori infection in Han ethnic population in Kunming.

Authors+Show Affiliations

Department of Pediatrics, The first Affiliated Hospital of Kunming Medical College, Kunming 650032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15941540

Citation

Wen, Ge-sheng, et al. "[Immunogenetic Analysis of Human Leukocyte Antigen DRB1, DQB1 Locus Among Han Ethnic Children With Helicobacter Pylori Infection in Kunming]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 26, no. 4, 2005, pp. 286-9.
Wen GS, Huang YK, Hao P, et al. [Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26(4):286-9.
Wen, G. S., Huang, Y. K., Hao, P., Li, H. L., Qi, Q., & Zhou, L. F. (2005). [Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 26(4), 286-9.
Wen GS, et al. [Immunogenetic Analysis of Human Leukocyte Antigen DRB1, DQB1 Locus Among Han Ethnic Children With Helicobacter Pylori Infection in Kunming]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26(4):286-9. PubMed PMID: 15941540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming]. AU - Wen,Ge-sheng, AU - Huang,Yong-kun, AU - Hao,Ping, AU - Li,Hai-lin, AU - Qi,Qin, AU - Zhou,Li-fang, PY - 2005/6/9/pubmed PY - 2007/7/11/medline PY - 2005/6/9/entrez SP - 286 EP - 9 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 26 IS - 4 N2 - OBJECTIVE: To explore the immunogenetic features of human leukocyte antigen DRB1, DQB1 locus and children with Helicobacter pylori (H. pylori) infection in Han ethnic population in Kunming and its association with digestive diseases and H. pylori to better understand the immunogenetic features of the H. pylori infection. METHODS: Polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to study the HLA-DRB1, DQB1 allelic frequency distribution on 35 children with H. pylori infection and 37 healthy controls in Han ethnic population in Kunming. RESULTS: Allelic frequencies of HLA-DRB1 * 0901, DQB1 * 03032 in the H. pylori infection group were lower than those of the healthy control group (7.14% vs. 31.08%, chi(2) = 13.16, Pc < 0.012; 5.71% vs. 25.68%, chi(2) = 10.68, Pc = 0.007) but the rest alleles' frequencies did not show significant differences. CONCLUSION: These result suggested that HLA-DRB1 * 0901, DQB1 * 03032 might protect the H. pylori infection in Han ethnic population in Kunming. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/15941540/[Immunogenetic_analysis_of_human_leukocyte_antigen_DRB1_DQB1_locus_among_Han_ethnic_children_with_Helicobacter_pylori_infection_in_Kunming]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0254-6450&amp;year=2005&amp;vol=26&amp;issue=4&amp;fpage=286 DB - PRIME DP - Unbound Medicine ER -