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Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections.

Abstract

BACKGROUND

The effect of coffee consumption on the cardiovascular system is still an unresolved issue. Aortic stiffness and wave reflections are important prognosticators of cardiovascular disease risk. We have shown that caffeine acutely increases aortic stiffness and wave reflections.

OBJECTIVE

The objective was to investigate the effect of chronic coffee consumption on aortic stiffness and wave reflections.

DESIGN

This was a cross-sectional study of 228 healthy subjects: 141 men (x +/- SD: 41 +/- 8 y old) and 87 women (41 +/- 9 y old). Aortic stiffness was evaluated with carotid-femoral pulse wave velocity (PWV). Wave reflections were evaluated with augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform with the use of high-fidelity pulse wave analysis. Coffee consumption was ascertained over 1 y with a food-frequency questionnaire.

RESULTS

A linear relation between coffee consumption and PWV, AIx, and AP was observed (P for trend < 0.05). Compared with the nonconsumption group, PWV was on average 13% higher, AIx was 2-fold higher, and AP was 2.4-fold higher (P < 0.01 for all) in the high-consumption group (>450 mL/d). The findings remained significant after control for confounders such as age, sex, smoking habits, body mass index, total and LDL cholesterol, triacylglycerols, blood glucose, mean blood pressure, and heart rate. The linear relation (P for trend < 0.05) observed between coffee consumption and arterial pressures was largely explained when the covariates were entered in the model.

CONCLUSIONS

Chronic coffee consumption exerts a detrimental effect on aortic stiffness and wave reflections, which may increase the risk of cardiovascular disease.

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  • Authors+Show Affiliations

    ,

    1st Department of Cardiology, Hippokration Hospital, School of Medicine, University of Athens, Athens, Greece. cvlachop@otenet.gr

    , , ,

    Source

    MeSH

    Adult
    Aorta
    Aortic Diseases
    Blood Flow Velocity
    Blood Pressure
    Caffeine
    Cardiovascular Diseases
    Central Nervous System Stimulants
    Coffee
    Confounding Factors (Epidemiology)
    Cross-Sectional Studies
    Elasticity
    Female
    Humans
    Longitudinal Studies
    Male
    Pulsatile Flow
    Surveys and Questionnaires
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15941880

    Citation

    Vlachopoulos, Charalambos, et al. "Chronic Coffee Consumption Has a Detrimental Effect On Aortic Stiffness and Wave Reflections." The American Journal of Clinical Nutrition, vol. 81, no. 6, 2005, pp. 1307-12.
    Vlachopoulos C, Panagiotakos D, Ioakeimidis N, et al. Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections. Am J Clin Nutr. 2005;81(6):1307-12.
    Vlachopoulos, C., Panagiotakos, D., Ioakeimidis, N., Dima, I., & Stefanadis, C. (2005). Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections. The American Journal of Clinical Nutrition, 81(6), pp. 1307-12.
    Vlachopoulos C, et al. Chronic Coffee Consumption Has a Detrimental Effect On Aortic Stiffness and Wave Reflections. Am J Clin Nutr. 2005;81(6):1307-12. PubMed PMID: 15941880.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections. AU - Vlachopoulos,Charalambos, AU - Panagiotakos,Demosthenes, AU - Ioakeimidis,Nikolaos, AU - Dima,Ioanna, AU - Stefanadis,Christodoulos, PY - 2005/6/9/pubmed PY - 2005/7/19/medline PY - 2005/6/9/entrez SP - 1307 EP - 12 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 81 IS - 6 N2 - BACKGROUND: The effect of coffee consumption on the cardiovascular system is still an unresolved issue. Aortic stiffness and wave reflections are important prognosticators of cardiovascular disease risk. We have shown that caffeine acutely increases aortic stiffness and wave reflections. OBJECTIVE: The objective was to investigate the effect of chronic coffee consumption on aortic stiffness and wave reflections. DESIGN: This was a cross-sectional study of 228 healthy subjects: 141 men (x +/- SD: 41 +/- 8 y old) and 87 women (41 +/- 9 y old). Aortic stiffness was evaluated with carotid-femoral pulse wave velocity (PWV). Wave reflections were evaluated with augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform with the use of high-fidelity pulse wave analysis. Coffee consumption was ascertained over 1 y with a food-frequency questionnaire. RESULTS: A linear relation between coffee consumption and PWV, AIx, and AP was observed (P for trend < 0.05). Compared with the nonconsumption group, PWV was on average 13% higher, AIx was 2-fold higher, and AP was 2.4-fold higher (P < 0.01 for all) in the high-consumption group (>450 mL/d). The findings remained significant after control for confounders such as age, sex, smoking habits, body mass index, total and LDL cholesterol, triacylglycerols, blood glucose, mean blood pressure, and heart rate. The linear relation (P for trend < 0.05) observed between coffee consumption and arterial pressures was largely explained when the covariates were entered in the model. CONCLUSIONS: Chronic coffee consumption exerts a detrimental effect on aortic stiffness and wave reflections, which may increase the risk of cardiovascular disease. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15941880/Chronic_coffee_consumption_has_a_detrimental_effect_on_aortic_stiffness_and_wave_reflections_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/81.6.1307 DB - PRIME DP - Unbound Medicine ER -