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Family history of cancer, its combination with smoking and drinking, and risk of squamous cell carcinoma of the esophagus.

Abstract

We analyzed the association between history of cancer in first-degree relatives and the risk of squamous cell carcinoma of the esophagus (SCCE) using data from three case-control studies conducted in Italy and Switzerland on 805 incident, histologically confirmed SCCE, and 3,461 hospital controls. The alcohol- and tobacco-adjusted odds ratio (OR) for a family history of esophageal cancer was 3.2 [95% confidence interval (CI), 1.7-6.2], and the OR was higher when the affected relative was a brother or was diagnosed at age <55 years. Compared to subjects without family history of esophageal cancer, non-current smokers, drinking <49 drinks per week, the OR was 2.9 (95% CI, 1.1-7.5) for family history alone, 15.5 (95% CI, 11.7-20.5) for current smokers drinking > or = 49 drinks per week without family history of esophageal cancer, and 107.0 (95% CI, 13.0-880.2) for current smokers drinking > or = 49 drinks per week who also had a family history of esophageal cancer. The risk of SCCE was also increased in subjects with a family history of cancer of the oral cavity/pharynx (OR, 3.7; 95% CI, 1.5-9.0) and stomach (OR, 2.0; 95% CI, 1.1-3.6), but not of other cancers, nor for a family history of any cancer (OR, 1.0; 95% CI, 0.8-1.4). These data show that, as for many other epithelial cancers, the risk of SCCE is increased in subjects with a family history of the disease, and that--in Western countries--avoidance of alcohol and tobacco is also the best way to prevent SCCE in subjects with a family history of the disease.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62-20157 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15941946

Citation

Garavello, Werner, et al. "Family History of Cancer, Its Combination With Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 6, 2005, pp. 1390-3.
Garavello W, Negri E, Talamini R, et al. Family history of cancer, its combination with smoking and drinking, and risk of squamous cell carcinoma of the esophagus. Cancer Epidemiol Biomarkers Prev. 2005;14(6):1390-3.
Garavello, W., Negri, E., Talamini, R., Levi, F., Zambon, P., Dal Maso, L., ... La Vecchia, C. (2005). Family history of cancer, its combination with smoking and drinking, and risk of squamous cell carcinoma of the esophagus. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(6), pp. 1390-3.
Garavello W, et al. Family History of Cancer, Its Combination With Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus. Cancer Epidemiol Biomarkers Prev. 2005;14(6):1390-3. PubMed PMID: 15941946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of cancer, its combination with smoking and drinking, and risk of squamous cell carcinoma of the esophagus. AU - Garavello,Werner, AU - Negri,Eva, AU - Talamini,Renato, AU - Levi,Fabio, AU - Zambon,Paola, AU - Dal Maso,Luigino, AU - Bosetti,Cristina, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, PY - 2005/6/9/pubmed PY - 2005/9/1/medline PY - 2005/6/9/entrez SP - 1390 EP - 3 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 6 N2 - We analyzed the association between history of cancer in first-degree relatives and the risk of squamous cell carcinoma of the esophagus (SCCE) using data from three case-control studies conducted in Italy and Switzerland on 805 incident, histologically confirmed SCCE, and 3,461 hospital controls. The alcohol- and tobacco-adjusted odds ratio (OR) for a family history of esophageal cancer was 3.2 [95% confidence interval (CI), 1.7-6.2], and the OR was higher when the affected relative was a brother or was diagnosed at age <55 years. Compared to subjects without family history of esophageal cancer, non-current smokers, drinking <49 drinks per week, the OR was 2.9 (95% CI, 1.1-7.5) for family history alone, 15.5 (95% CI, 11.7-20.5) for current smokers drinking > or = 49 drinks per week without family history of esophageal cancer, and 107.0 (95% CI, 13.0-880.2) for current smokers drinking > or = 49 drinks per week who also had a family history of esophageal cancer. The risk of SCCE was also increased in subjects with a family history of cancer of the oral cavity/pharynx (OR, 3.7; 95% CI, 1.5-9.0) and stomach (OR, 2.0; 95% CI, 1.1-3.6), but not of other cancers, nor for a family history of any cancer (OR, 1.0; 95% CI, 0.8-1.4). These data show that, as for many other epithelial cancers, the risk of SCCE is increased in subjects with a family history of the disease, and that--in Western countries--avoidance of alcohol and tobacco is also the best way to prevent SCCE in subjects with a family history of the disease. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15941946/Family_history_of_cancer_its_combination_with_smoking_and_drinking_and_risk_of_squamous_cell_carcinoma_of_the_esophagus_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15941946 DB - PRIME DP - Unbound Medicine ER -