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Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up.

Abstract

BACKGROUND

The aim of the current study was to evaluate the relation between physical activity and prostate cancer risk with specific emphasis on interaction with body mass index (BMI) and baseline energy intake.

METHODS

The association between prostate cancer and physical activity was evaluated in the Netherlands Cohort Study, conducted among 58,279 men ages 55 to 69 years at entry. Information regarding baseline nonoccupational physical activity, history of sports participation, and occupational physical activity was collected with a questionnaire in 1986. After 9.3 years, 1,386 incident prostate cancer cases were available for case-cohort analyses. Multivariate incidence rate ratios (RR) and corresponding 95% confidence intervals (95% CI) were calculated using Cox regression analyses.

RESULTS

Neither baseline nonoccupational physical activity (RR, 1.01; 95% CI, 0.81-1.25 for >90 versus <30 minutes per day), history of sports participation (RR, 1.04; 95% CI, 0.90-1.22 for ever versus never participated), nor occupational physical activity (RR, 0.91; 95% CI, 0.70-1.18 for >12 versus <8 KJ/min energy expenditure in the longest held job) showed an inverse relation with prostate cancer risk. We found an increased risk of prostate cancer for men who were physically active for >1 hour per day in obese men (BMI > 30) and men with a high baseline energy intake.

DISCUSSION

The results of this current study do not support the hypothesis that physical activity protects against prostate cancer in men.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, Netherlands. m.p.zeegers@bham.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15941961

Citation

Zeegers, Maurice P A., et al. "Physical Activity and the Risk of Prostate Cancer in the Netherlands Cohort Study, Results After 9.3 Years of Follow-up." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 6, 2005, pp. 1490-5.
Zeegers MP, Dirx MJ, van den Brandt PA. Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiol Biomarkers Prev. 2005;14(6):1490-5.
Zeegers, M. P., Dirx, M. J., & van den Brandt, P. A. (2005). Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(6), pp. 1490-5.
Zeegers MP, Dirx MJ, van den Brandt PA. Physical Activity and the Risk of Prostate Cancer in the Netherlands Cohort Study, Results After 9.3 Years of Follow-up. Cancer Epidemiol Biomarkers Prev. 2005;14(6):1490-5. PubMed PMID: 15941961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. AU - Zeegers,Maurice P A, AU - Dirx,Miranda J M, AU - van den Brandt,Piet A, PY - 2005/6/9/pubmed PY - 2005/9/1/medline PY - 2005/6/9/entrez SP - 1490 EP - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 6 N2 - BACKGROUND: The aim of the current study was to evaluate the relation between physical activity and prostate cancer risk with specific emphasis on interaction with body mass index (BMI) and baseline energy intake. METHODS: The association between prostate cancer and physical activity was evaluated in the Netherlands Cohort Study, conducted among 58,279 men ages 55 to 69 years at entry. Information regarding baseline nonoccupational physical activity, history of sports participation, and occupational physical activity was collected with a questionnaire in 1986. After 9.3 years, 1,386 incident prostate cancer cases were available for case-cohort analyses. Multivariate incidence rate ratios (RR) and corresponding 95% confidence intervals (95% CI) were calculated using Cox regression analyses. RESULTS: Neither baseline nonoccupational physical activity (RR, 1.01; 95% CI, 0.81-1.25 for >90 versus <30 minutes per day), history of sports participation (RR, 1.04; 95% CI, 0.90-1.22 for ever versus never participated), nor occupational physical activity (RR, 0.91; 95% CI, 0.70-1.18 for >12 versus <8 KJ/min energy expenditure in the longest held job) showed an inverse relation with prostate cancer risk. We found an increased risk of prostate cancer for men who were physically active for >1 hour per day in obese men (BMI > 30) and men with a high baseline energy intake. DISCUSSION: The results of this current study do not support the hypothesis that physical activity protects against prostate cancer in men. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15941961/Physical_activity_and_the_risk_of_prostate_cancer_in_the_Netherlands_cohort_study_results_after_9_3_years_of_follow_up_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15941961 DB - PRIME DP - Unbound Medicine ER -