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Current concepts in therapy of chronic rhinosinusitis and nasal polyposis.

Abstract

The exact pathophysiological mechanisms leading to chronic rhinosinusitis (CRS) still to a large extent remain obscure. However, recently there has been some progress in elucidating the etiology of nasal polyposis, especially regarding tissue eosinophilia as well as the role of aspirin intolerance and eicosanoid mediators. Endonasal sinus surgery has evolved to be the treatment of choice in CRS and nasal polyposis in all cases where conservative treatment has failed or resulted in only a partial or temporary relief. Today, state of the art in surgical technique includes the ability to combine microscopic and endoscopic procedures. Regardless of technical advances like powered instrumentation or computer-aided surgery, in a modern protocol, surgical therapy can offer only one option within a complex and individually tailored therapeutical concept. This review discusses current concepts and new developments in the diagnosis and treatment of CRS and nasal polyposis.

Authors+Show Affiliations

Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Mainz, Mainz, Germany. gosepath@hno.klinik.uni-mainz.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15942266

Citation

Gosepath, Jan, and Wolf J. Mann. "Current Concepts in Therapy of Chronic Rhinosinusitis and Nasal Polyposis." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 67, no. 3, 2005, pp. 125-36.
Gosepath J, Mann WJ. Current concepts in therapy of chronic rhinosinusitis and nasal polyposis. ORL J Otorhinolaryngol Relat Spec. 2005;67(3):125-36.
Gosepath, J., & Mann, W. J. (2005). Current concepts in therapy of chronic rhinosinusitis and nasal polyposis. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 67(3), pp. 125-36.
Gosepath J, Mann WJ. Current Concepts in Therapy of Chronic Rhinosinusitis and Nasal Polyposis. ORL J Otorhinolaryngol Relat Spec. 2005;67(3):125-36. PubMed PMID: 15942266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current concepts in therapy of chronic rhinosinusitis and nasal polyposis. AU - Gosepath,Jan, AU - Mann,Wolf J, PY - 2004/02/18/received PY - 2004/07/01/accepted PY - 2005/6/9/pubmed PY - 2006/5/16/medline PY - 2005/6/9/entrez SP - 125 EP - 36 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 67 IS - 3 N2 - The exact pathophysiological mechanisms leading to chronic rhinosinusitis (CRS) still to a large extent remain obscure. However, recently there has been some progress in elucidating the etiology of nasal polyposis, especially regarding tissue eosinophilia as well as the role of aspirin intolerance and eicosanoid mediators. Endonasal sinus surgery has evolved to be the treatment of choice in CRS and nasal polyposis in all cases where conservative treatment has failed or resulted in only a partial or temporary relief. Today, state of the art in surgical technique includes the ability to combine microscopic and endoscopic procedures. Regardless of technical advances like powered instrumentation or computer-aided surgery, in a modern protocol, surgical therapy can offer only one option within a complex and individually tailored therapeutical concept. This review discusses current concepts and new developments in the diagnosis and treatment of CRS and nasal polyposis. SN - 0301-1569 UR - https://www.unboundmedicine.com/medline/citation/15942266/Current_concepts_in_therapy_of_chronic_rhinosinusitis_and_nasal_polyposis_ L2 - https://www.karger.com?DOI=10.1159/000086075 DB - PRIME DP - Unbound Medicine ER -