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Microscopic morphology and histology of the human meninges.
Morphologie 2005; 89(284):22-34M

Abstract

The meninges comprise the dura mater and the leptomeninges (arachnoid and pia mater). Dura forms an outer endosteal layer related to the bones of the skull and spine and an inner layer closely applied to the arachnoid mater. Leptomeninges have multiple functions and anatomical relationships. The outer parietal layer of arachnoid is impermeable to CSF due to tight intercellular junctions; elsewhere leptomeningeal cells form demosomes and gap junctions. Trabeculae of leptomeninges compartmentalize the subarachnoid space and join the pia to arachnoid mater. In bacterial meningitis leptomeningeal cells secrete cytokines. Pia mater is reflected from the surface of the brain and spinal cord onto arteries and veins, thus separating the subarachnoid space from the brain and cord. A sheath of leptomeninges accompanies arteries into the brain and is related to the pathways for the drainage of interstitial fluid that play a role in inflammatory responses in the brain and appear to be blocked by amyloid-beta in Alzheimer's disease. Specialised leptomeningeal cells in the stroma of the choroid plexus form collagen whorls that become calcified with age. Leptomeningeal cells also form channels in the core and apical cap of arachnoid granulations for the drainage of CSF into venous sinuses. In the spine, leptomeninges form highly perforated intermediate sheets of arachnoid and delicate ligaments that compartmentalize the subarachnoid space; dentate ligaments anchor subpial collagen to the dura mater and stabilize the spinal cord. Despite the multiple anatomical arrangements and physiological functions, leptomeningeal cells retain many histological features that are similar from site to site.

Authors+Show Affiliations

Clinical Neurosciences, Southampton University School of Medicine, Mail Point 813, Southampton General Hospital, Southampton SO16 6YD, UK. row@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15943078

Citation

Weller, R O.. "Microscopic Morphology and Histology of the Human Meninges." Morphologie : Bulletin De l'Association Des Anatomistes, vol. 89, no. 284, 2005, pp. 22-34.
Weller RO. Microscopic morphology and histology of the human meninges. Morphologie. 2005;89(284):22-34.
Weller, R. O. (2005). Microscopic morphology and histology of the human meninges. Morphologie : Bulletin De l'Association Des Anatomistes, 89(284), pp. 22-34.
Weller RO. Microscopic Morphology and Histology of the Human Meninges. Morphologie. 2005;89(284):22-34. PubMed PMID: 15943078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microscopic morphology and histology of the human meninges. A1 - Weller,R O, PY - 2005/6/10/pubmed PY - 2006/2/24/medline PY - 2005/6/10/entrez SP - 22 EP - 34 JF - Morphologie : bulletin de l'Association des anatomistes JO - Morphologie VL - 89 IS - 284 N2 - The meninges comprise the dura mater and the leptomeninges (arachnoid and pia mater). Dura forms an outer endosteal layer related to the bones of the skull and spine and an inner layer closely applied to the arachnoid mater. Leptomeninges have multiple functions and anatomical relationships. The outer parietal layer of arachnoid is impermeable to CSF due to tight intercellular junctions; elsewhere leptomeningeal cells form demosomes and gap junctions. Trabeculae of leptomeninges compartmentalize the subarachnoid space and join the pia to arachnoid mater. In bacterial meningitis leptomeningeal cells secrete cytokines. Pia mater is reflected from the surface of the brain and spinal cord onto arteries and veins, thus separating the subarachnoid space from the brain and cord. A sheath of leptomeninges accompanies arteries into the brain and is related to the pathways for the drainage of interstitial fluid that play a role in inflammatory responses in the brain and appear to be blocked by amyloid-beta in Alzheimer's disease. Specialised leptomeningeal cells in the stroma of the choroid plexus form collagen whorls that become calcified with age. Leptomeningeal cells also form channels in the core and apical cap of arachnoid granulations for the drainage of CSF into venous sinuses. In the spine, leptomeninges form highly perforated intermediate sheets of arachnoid and delicate ligaments that compartmentalize the subarachnoid space; dentate ligaments anchor subpial collagen to the dura mater and stabilize the spinal cord. Despite the multiple anatomical arrangements and physiological functions, leptomeningeal cells retain many histological features that are similar from site to site. SN - 1286-0115 UR - https://www.unboundmedicine.com/medline/citation/15943078/Microscopic_morphology_and_histology_of_the_human_meninges_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1286-0115(05)83235-7 DB - PRIME DP - Unbound Medicine ER -