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Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS).
Clin Endocrinol (Oxf) 2005; 62(6):644-9CE

Abstract

OBJECTIVE

To determine the prevalence of adrenal androgen (AA) excess in the polycystic ovary syndrome (PCOS) using age- and race-specific normative values.

DESIGN

Cross-sectional observational study.

PATIENTS

One hundred and eight-two (88 Black and 94 White) age-matched healthy eumenorrhoeic nonhirsute women (controls) and 213 (27 Black and 186 White) women with PCOS were recruited.

MEASUREMENTS

Total testosterone (T), free T, androstenedione (A4), dehydroepiandrosterone sulfate (DHEAS) and SHBG, as well as fasting insulin and glucose, were measured in plasma.

RESULTS

The mean total T, free T, A4, DHEAS and body mass index (BMI) were higher in women with PCOS than in control women. DHEAS levels were significantly lower in Black controls than White controls, whereas fasting insulin and BMI were higher in Black controls. In control and Black PCOS women, DHEAS levels did not correlate with BMI, waist-to-hip ratio (WHR) or fasting insulin. Among White women with PCOS, DHEAS levels correlated negatively with BMI and fasting insulin. DHEAS levels decreased similarly with age in control and PCOS women of either race. For each race and age group the upper 95% normative values for log DHEAS was calculated, and the number of PCOS subjects with log DHEAS values above this level were assessed. The prevalence of supranormal DHEAS levels was 33.3% and 19.9%, respectively, among Black and White women with PCOS.

CONCLUSIONS

The prevalence of DHEAS excess is approximately 20% among White and 30% among Black PCOS patients, when using age- and race-adjusted normative values. This study also indicates that the age-associated decline in DHEAS levels is observable and similar in both control and PCOS women, regardless of race. While BMI and fasting insulin had little impact on circulating DHEAS levels in healthy women, among White PCOS patients these parameters were negatively associated with circulating DHEAS levels.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15943823

Citation

Kumar, Ashim, et al. "Prevalence of Adrenal Androgen Excess in Patients With the Polycystic Ovary Syndrome (PCOS)." Clinical Endocrinology, vol. 62, no. 6, 2005, pp. 644-9.
Kumar A, Woods KS, Bartolucci AA, et al. Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf). 2005;62(6):644-9.
Kumar, A., Woods, K. S., Bartolucci, A. A., & Azziz, R. (2005). Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS). Clinical Endocrinology, 62(6), pp. 644-9.
Kumar A, et al. Prevalence of Adrenal Androgen Excess in Patients With the Polycystic Ovary Syndrome (PCOS). Clin Endocrinol (Oxf). 2005;62(6):644-9. PubMed PMID: 15943823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS). AU - Kumar,Ashim, AU - Woods,Keslie S, AU - Bartolucci,Alfred A, AU - Azziz,Ricardo, PY - 2005/6/10/pubmed PY - 2005/8/12/medline PY - 2005/6/10/entrez SP - 644 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 62 IS - 6 N2 - OBJECTIVE: To determine the prevalence of adrenal androgen (AA) excess in the polycystic ovary syndrome (PCOS) using age- and race-specific normative values. DESIGN: Cross-sectional observational study. PATIENTS: One hundred and eight-two (88 Black and 94 White) age-matched healthy eumenorrhoeic nonhirsute women (controls) and 213 (27 Black and 186 White) women with PCOS were recruited. MEASUREMENTS: Total testosterone (T), free T, androstenedione (A4), dehydroepiandrosterone sulfate (DHEAS) and SHBG, as well as fasting insulin and glucose, were measured in plasma. RESULTS: The mean total T, free T, A4, DHEAS and body mass index (BMI) were higher in women with PCOS than in control women. DHEAS levels were significantly lower in Black controls than White controls, whereas fasting insulin and BMI were higher in Black controls. In control and Black PCOS women, DHEAS levels did not correlate with BMI, waist-to-hip ratio (WHR) or fasting insulin. Among White women with PCOS, DHEAS levels correlated negatively with BMI and fasting insulin. DHEAS levels decreased similarly with age in control and PCOS women of either race. For each race and age group the upper 95% normative values for log DHEAS was calculated, and the number of PCOS subjects with log DHEAS values above this level were assessed. The prevalence of supranormal DHEAS levels was 33.3% and 19.9%, respectively, among Black and White women with PCOS. CONCLUSIONS: The prevalence of DHEAS excess is approximately 20% among White and 30% among Black PCOS patients, when using age- and race-adjusted normative values. This study also indicates that the age-associated decline in DHEAS levels is observable and similar in both control and PCOS women, regardless of race. While BMI and fasting insulin had little impact on circulating DHEAS levels in healthy women, among White PCOS patients these parameters were negatively associated with circulating DHEAS levels. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15943823/Prevalence_of_adrenal_androgen_excess_in_patients_with_the_polycystic_ovary_syndrome__PCOS__ L2 - https://doi.org/10.1111/j.1365-2265.2005.02256.x DB - PRIME DP - Unbound Medicine ER -