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A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure.
Clin Endocrinol (Oxf). 2005 Jun; 62(6):713-20.CE

Abstract

OBJECTIVE

Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism.

DESIGN

A population study including 4649 randomly selected subjects.

MEASUREMENTS

Blood tests were used to analyse for thyroid peroxidase autoantibodies (TPO-Ab), thyroglobulin autoantibodies (Tg-Ab), TSH, fT3 and fT4.

RESULTS

Thyroid volume was categorized as small (< 6.6 ml) in 4.7%, normal (6.6-14.9 ml) in 60.4% and large (> 14.9 ml) in 34.9% of participants. Thyroid nodules were found in 29.7%. Serum TSH was low (< 0.4 mIU/l) in 4.7%, normal (0.4-3.6) in 91.0% and high (> 3.6) in 4.3%. The prevalence rate of subclinical goitrous Hashimoto's disease was 0.62% and of subclinical autoimmune atrophic thyroiditis 0.24%. There was a strong association between large volume and autoantibodies, but only in subjects with elevated TSH (P < 0.001). An association between thyroid nodules and TPO-Ab in univariate analyses (P < 0.001) was due to confounding by sex and age (multivariate model, P = 0.23).

CONCLUSION

We identified a subgroup of the population with subclinical goitrous Hashimoto's disease and a smaller subgroup with subclinical autoimmune atrophic thyroiditis. This relationship between small and large thyroid volume in subclinical disease is opposite to that in overt disease, which may suggest that the period between development of a small volume with circulating autoantibodies and overt hypothyroidism is relatively short.

Authors+Show Affiliations

Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Denmark. Ibulow@aas.nja.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15943834

Citation

Bülow Pedersen, Inge, et al. "A Population Study of the Association Between Thyroid Autoantibodies in Serum and Abnormalities in Thyroid Function and Structure." Clinical Endocrinology, vol. 62, no. 6, 2005, pp. 713-20.
Bülow Pedersen I, Laurberg P, Knudsen N, et al. A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clin Endocrinol (Oxf). 2005;62(6):713-20.
Bülow Pedersen, I., Laurberg, P., Knudsen, N., Jørgensen, T., Perrild, H., Ovesen, L., & Rasmussen, L. B. (2005). A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clinical Endocrinology, 62(6), 713-20.
Bülow Pedersen I, et al. A Population Study of the Association Between Thyroid Autoantibodies in Serum and Abnormalities in Thyroid Function and Structure. Clin Endocrinol (Oxf). 2005;62(6):713-20. PubMed PMID: 15943834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. AU - Bülow Pedersen,Inge, AU - Laurberg,Peter, AU - Knudsen,Nils, AU - Jørgensen,Torben, AU - Perrild,Hans, AU - Ovesen,Lars, AU - Rasmussen,Lone Banke, PY - 2005/6/10/pubmed PY - 2005/8/12/medline PY - 2005/6/10/entrez SP - 713 EP - 20 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 62 IS - 6 N2 - OBJECTIVE: Patients with autoimmune overt hypothyroidism may present with goitrous Hashimoto's disease or autoimmune atrophic thyroiditis. Little is known about the prevalence of subclinical autoimmune hypothyroidism. The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism. DESIGN: A population study including 4649 randomly selected subjects. MEASUREMENTS: Blood tests were used to analyse for thyroid peroxidase autoantibodies (TPO-Ab), thyroglobulin autoantibodies (Tg-Ab), TSH, fT3 and fT4. RESULTS: Thyroid volume was categorized as small (< 6.6 ml) in 4.7%, normal (6.6-14.9 ml) in 60.4% and large (> 14.9 ml) in 34.9% of participants. Thyroid nodules were found in 29.7%. Serum TSH was low (< 0.4 mIU/l) in 4.7%, normal (0.4-3.6) in 91.0% and high (> 3.6) in 4.3%. The prevalence rate of subclinical goitrous Hashimoto's disease was 0.62% and of subclinical autoimmune atrophic thyroiditis 0.24%. There was a strong association between large volume and autoantibodies, but only in subjects with elevated TSH (P < 0.001). An association between thyroid nodules and TPO-Ab in univariate analyses (P < 0.001) was due to confounding by sex and age (multivariate model, P = 0.23). CONCLUSION: We identified a subgroup of the population with subclinical goitrous Hashimoto's disease and a smaller subgroup with subclinical autoimmune atrophic thyroiditis. This relationship between small and large thyroid volume in subclinical disease is opposite to that in overt disease, which may suggest that the period between development of a small volume with circulating autoantibodies and overt hypothyroidism is relatively short. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15943834/A_population_study_of_the_association_between_thyroid_autoantibodies_in_serum_and_abnormalities_in_thyroid_function_and_structure_ L2 - https://doi.org/10.1111/j.1365-2265.2005.02284.x DB - PRIME DP - Unbound Medicine ER -