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The level of response to alcohol in daughters of alcoholics and controls.
Drug Alcohol Depend. 2005 Jul; 79(1):83-93.DA

Abstract

BACKGROUND

The low level of response (LR) to alcohol is a genetically influenced characteristic related to the development of alcohol use disorders (AUDs). This phenotype is found in men with a family history (FH) of alcoholism, predicts future AUDs, and has heritabilities as high as 60%. However, despite evidence of genetic influences for AUDs in both sexes, the majority of studies evaluating differences in LR across high- and low-risk groups have been conducted on males, and it is unclear how generalizable these results are to women.

METHODS

Twenty-five women who are family history positive (FHP) for alcohol dependence were matched with 25 women with no FH of alcoholism (FHN) on factors that may impact LR. Using an alcohol challenge paradigm, data on the reaction to a moderate dose of alcohol were gathered over a period of 3.5 h. Assessments included breath alcohol concentrations (BrACs), the Subjective High Assessment Scale (SHAS), as well as body sway or static ataxia.

RESULTS

Family history positives reported lower subjective intoxication than FHNs. In addition, when body sway scores were corrected for skewness, FHPs had significantly lower scores on alcohol-related changes in lateral sway. These differences remained after considering the effects of drinking history and BrAC values.

CONCLUSIONS

This study evaluated the LR to alcohol in the largest sample of alcohol challenges in matched FHP and FHN women to date. Overall, the findings are consistent with most data from earlier investigations of smaller sized samples of FHP women. The results suggest that, similar to sons of alcoholics, a low LR to alcohol might also be characteristic of daughters of alcoholics.

Authors+Show Affiliations

San Diego State University, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15943947

Citation

Eng, Mimy Y., et al. "The Level of Response to Alcohol in Daughters of Alcoholics and Controls." Drug and Alcohol Dependence, vol. 79, no. 1, 2005, pp. 83-93.
Eng MY, Schuckit MA, Smith TL. The level of response to alcohol in daughters of alcoholics and controls. Drug Alcohol Depend. 2005;79(1):83-93.
Eng, M. Y., Schuckit, M. A., & Smith, T. L. (2005). The level of response to alcohol in daughters of alcoholics and controls. Drug and Alcohol Dependence, 79(1), 83-93.
Eng MY, Schuckit MA, Smith TL. The Level of Response to Alcohol in Daughters of Alcoholics and Controls. Drug Alcohol Depend. 2005;79(1):83-93. PubMed PMID: 15943947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The level of response to alcohol in daughters of alcoholics and controls. AU - Eng,Mimy Y, AU - Schuckit,Marc A, AU - Smith,Tom L, PY - 2004/08/04/received PY - 2004/12/29/revised PY - 2005/01/10/accepted PY - 2005/6/10/pubmed PY - 2005/11/9/medline PY - 2005/6/10/entrez SP - 83 EP - 93 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 79 IS - 1 N2 - BACKGROUND: The low level of response (LR) to alcohol is a genetically influenced characteristic related to the development of alcohol use disorders (AUDs). This phenotype is found in men with a family history (FH) of alcoholism, predicts future AUDs, and has heritabilities as high as 60%. However, despite evidence of genetic influences for AUDs in both sexes, the majority of studies evaluating differences in LR across high- and low-risk groups have been conducted on males, and it is unclear how generalizable these results are to women. METHODS: Twenty-five women who are family history positive (FHP) for alcohol dependence were matched with 25 women with no FH of alcoholism (FHN) on factors that may impact LR. Using an alcohol challenge paradigm, data on the reaction to a moderate dose of alcohol were gathered over a period of 3.5 h. Assessments included breath alcohol concentrations (BrACs), the Subjective High Assessment Scale (SHAS), as well as body sway or static ataxia. RESULTS: Family history positives reported lower subjective intoxication than FHNs. In addition, when body sway scores were corrected for skewness, FHPs had significantly lower scores on alcohol-related changes in lateral sway. These differences remained after considering the effects of drinking history and BrAC values. CONCLUSIONS: This study evaluated the LR to alcohol in the largest sample of alcohol challenges in matched FHP and FHN women to date. Overall, the findings are consistent with most data from earlier investigations of smaller sized samples of FHP women. The results suggest that, similar to sons of alcoholics, a low LR to alcohol might also be characteristic of daughters of alcoholics. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/15943947/The_level_of_response_to_alcohol_in_daughters_of_alcoholics_and_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(05)00023-2 DB - PRIME DP - Unbound Medicine ER -