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Evaluation of the Cozart RapiScan drug test system for opiates and cocaine in oral fluid.
Forensic Sci Int. 2005 Jun 10; 150(2-3):239-43.FS

Abstract

The purpose of this study was to evaluate the efficiency of the Cozart RapiScan (CRS) drug test system for detecting opiates and cocaine in oral fluid. Oral fluid samples were collected using the Cozart RapiScan collection system from 358 donors who were receiving treatment for their addiction and were monitored for drug misuse. A further 103 oral fluid samples were collected from volunteer donors who were not drug users. The samples were analyzed in the laboratory using the two-panel Cozart RapiScan cartridge for opiates and cocaine and confirmed using gas chromatography-mass spectrometry (GC-MS). The samples were stored frozen at -20 degrees C until analysis by GC-MS. The overall accuracy of the CRS for both opiates and cocaine was 100%. Samples spiked at 50% above and below the cut-off consistently gave negative and positive results respectively. A total of 88 samples were positive for various opiates and 111 samples were positive for cocaine and/or its metabolites. The CRS for opiates and cocaine in oral fluid, using a cut-off of 30 ng/mL morphine or benzoylecgonine equivalents in neat oral fluid, had overall efficiencies of 98% and 99%, respectively, versus GC-MS. A series of potential adulterants of oral fluid were evaluated and shown not to alter the outcome of the test result.

Authors+Show Affiliations

Cozart Bioscience Ltd., Abingdon, Oxfordshire OX14 4RY, UK. cooper@cozart.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15944065

Citation

Cooper, Gail, et al. "Evaluation of the Cozart RapiScan Drug Test System for Opiates and Cocaine in Oral Fluid." Forensic Science International, vol. 150, no. 2-3, 2005, pp. 239-43.
Cooper G, Wilson L, Reid C, et al. Evaluation of the Cozart RapiScan drug test system for opiates and cocaine in oral fluid. Forensic Sci Int. 2005;150(2-3):239-43.
Cooper, G., Wilson, L., Reid, C., Main, L., & Hand, C. (2005). Evaluation of the Cozart RapiScan drug test system for opiates and cocaine in oral fluid. Forensic Science International, 150(2-3), 239-43.
Cooper G, et al. Evaluation of the Cozart RapiScan Drug Test System for Opiates and Cocaine in Oral Fluid. Forensic Sci Int. 2005 Jun 10;150(2-3):239-43. PubMed PMID: 15944065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the Cozart RapiScan drug test system for opiates and cocaine in oral fluid. AU - Cooper,Gail, AU - Wilson,Lisa, AU - Reid,Claire, AU - Main,Lianne, AU - Hand,Chris, Y1 - 2005/04/15/ PY - 2004/09/28/received PY - 2004/12/24/revised PY - 2004/12/24/accepted PY - 2005/6/10/pubmed PY - 2005/9/9/medline PY - 2005/6/10/entrez SP - 239 EP - 43 JF - Forensic science international JO - Forensic Sci. Int. VL - 150 IS - 2-3 N2 - The purpose of this study was to evaluate the efficiency of the Cozart RapiScan (CRS) drug test system for detecting opiates and cocaine in oral fluid. Oral fluid samples were collected using the Cozart RapiScan collection system from 358 donors who were receiving treatment for their addiction and were monitored for drug misuse. A further 103 oral fluid samples were collected from volunteer donors who were not drug users. The samples were analyzed in the laboratory using the two-panel Cozart RapiScan cartridge for opiates and cocaine and confirmed using gas chromatography-mass spectrometry (GC-MS). The samples were stored frozen at -20 degrees C until analysis by GC-MS. The overall accuracy of the CRS for both opiates and cocaine was 100%. Samples spiked at 50% above and below the cut-off consistently gave negative and positive results respectively. A total of 88 samples were positive for various opiates and 111 samples were positive for cocaine and/or its metabolites. The CRS for opiates and cocaine in oral fluid, using a cut-off of 30 ng/mL morphine or benzoylecgonine equivalents in neat oral fluid, had overall efficiencies of 98% and 99%, respectively, versus GC-MS. A series of potential adulterants of oral fluid were evaluated and shown not to alter the outcome of the test result. SN - 0379-0738 UR - https://www.unboundmedicine.com/medline/citation/15944065/Evaluation_of_the_Cozart_RapiScan_drug_test_system_for_opiates_and_cocaine_in_oral_fluid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(05)00135-0 DB - PRIME DP - Unbound Medicine ER -