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The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults.

Abstract

This study determined whether stressful life events and social support were related to antibody status following both thymus-dependent and thymus-independent vaccinations. Life events in the previous year and customary social support were measured in 57 healthy students at baseline. Antibody status was also assessed at baseline and at five weeks and five months following vaccination with the trivalent influenza vaccine and the meningococcal A+C polysaccharide vaccine. Taking into account baseline antibody titre, high life events scores prior to vaccination were associated with lower responses to the B/Shangdong influenza strain at both five weeks and five months and meningococcal C at five weeks. Life event scores were not associated with response to the other two influenza viral strains nor response to meningococcal A. Those with high social support scores had stronger 5-week and 5-month antibody responses to the A/Panama influenza strain, but not to any of the other strains. These associations could not be accounted for by demographic or health behaviour factors, and also emerged from analyses comparing those who exhibited a fourfold increase in antibody titre from baseline with those who did not. Life events and social support were related to antibody status following influenza vaccination in distinctive ways that may be partly determined by vaccine novelty and prior naturalistic exposure. Life events also predicted poor antibody response to meningococcal C polysaccharide vaccination after previous meningococcal C conjugate vaccination. Neither psychosocial factor was associated with response to primary meningococcal A polysaccharide vaccination.

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  • Authors+Show Affiliations

    ,

    School of Sport and Exercise Sciences, University of Birmingham, UK. a.c.phillips@bham.ac.uk

    , , ,

    Source

    Brain, behavior, and immunity 19:4 2005 Jul pg 325-33

    MeSH

    Adult
    Analysis of Variance
    Antibodies
    Antibody Formation
    Female
    Follow-Up Studies
    Humans
    Influenza Vaccines
    Influenzavirus A
    Influenzavirus B
    Life Change Events
    Male
    Meningococcal Vaccines
    Polysaccharides, Bacterial
    Social Support
    Species Specificity
    Stress, Psychological
    T-Lymphocytes

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    15944072

    Citation

    Phillips, Anna C., et al. "The Association Between Life Events, Social Support, and Antibody Status Following Thymus-dependent and Thymus-independent Vaccinations in Healthy Young Adults." Brain, Behavior, and Immunity, vol. 19, no. 4, 2005, pp. 325-33.
    Phillips AC, Burns VE, Carroll D, et al. The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults. Brain Behav Immun. 2005;19(4):325-33.
    Phillips, A. C., Burns, V. E., Carroll, D., Ring, C., & Drayson, M. (2005). The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults. Brain, Behavior, and Immunity, 19(4), pp. 325-33.
    Phillips AC, et al. The Association Between Life Events, Social Support, and Antibody Status Following Thymus-dependent and Thymus-independent Vaccinations in Healthy Young Adults. Brain Behav Immun. 2005;19(4):325-33. PubMed PMID: 15944072.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults. AU - Phillips,Anna C, AU - Burns,Victoria E, AU - Carroll,Douglas, AU - Ring,Christopher, AU - Drayson,Mark, Y1 - 2004/12/15/ PY - 2004/09/07/received PY - 2004/10/25/revised PY - 2004/10/25/accepted PY - 2005/6/10/pubmed PY - 2005/9/28/medline PY - 2005/6/10/entrez SP - 325 EP - 33 JF - Brain, behavior, and immunity JO - Brain Behav. Immun. VL - 19 IS - 4 N2 - This study determined whether stressful life events and social support were related to antibody status following both thymus-dependent and thymus-independent vaccinations. Life events in the previous year and customary social support were measured in 57 healthy students at baseline. Antibody status was also assessed at baseline and at five weeks and five months following vaccination with the trivalent influenza vaccine and the meningococcal A+C polysaccharide vaccine. Taking into account baseline antibody titre, high life events scores prior to vaccination were associated with lower responses to the B/Shangdong influenza strain at both five weeks and five months and meningococcal C at five weeks. Life event scores were not associated with response to the other two influenza viral strains nor response to meningococcal A. Those with high social support scores had stronger 5-week and 5-month antibody responses to the A/Panama influenza strain, but not to any of the other strains. These associations could not be accounted for by demographic or health behaviour factors, and also emerged from analyses comparing those who exhibited a fourfold increase in antibody titre from baseline with those who did not. Life events and social support were related to antibody status following influenza vaccination in distinctive ways that may be partly determined by vaccine novelty and prior naturalistic exposure. Life events also predicted poor antibody response to meningococcal C polysaccharide vaccination after previous meningococcal C conjugate vaccination. Neither psychosocial factor was associated with response to primary meningococcal A polysaccharide vaccination. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/15944072/The_association_between_life_events_social_support_and_antibody_status_following_thymus_dependent_and_thymus_independent_vaccinations_in_healthy_young_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(04)00134-5 DB - PRIME DP - Unbound Medicine ER -