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Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood.
Synapse. 2005 Sep 01; 57(3):148-59.S

Abstract

This study determined whether developmental and adult 3,4-methylenedioxymethamphetamine (MDMA) exposures in rats have interactive effects on body temperature, learning, other behaviors, and monoamine concentrations in the hippocampus, prefrontal cortex, and striatum. Learning was assessed in the Cincinnati water maze (CWM), Morris water maze (MWM), and novel object recognition (NOR). On acquisition trials in the MWM, significant differences from developmental MDMA exposure were found on latency, cumulative distance, path length, and angle of first bearing to the goal, but the early and adult MDMA exposure group performed no worse than the developmental-only MDMA group. In the reversal trials, however, an interaction was seen: latency to the goal, cumulative distance, and angle of first bearing were increased in animals treated both developmentally and in adulthood with MDMA compared with those treated only developmentally. Other tests (elevated zero maze, CWM, NOR, and open-field activity) did not show an interaction, nor did hippocampal concentrations of serotonin or dopamine. However, several behavioral tests showed neonatal MDMA effects, including increased errors in the CWM, reduced time spent with a new object in the NOR test, and reduced locomotor activity in the open-field. By contrast, adult MDMA decreased the number of entries into open quadrants of the elevated zero maze. Litter effects were controlled by treating litter as the experimental unit and using mixed models repeated measures analyses. Correlational analyses suggested that the MWM reversal interaction involves multiple monoamine changes. The results indicate that developmental MDMA exposure can interact with adult exposure to interfere with some aspects of learning.

Authors+Show Affiliations

Division of Neurology, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15945064

Citation

Cohen, Martha A., et al. "Learning and Memory After Neonatal Exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in Rats: Interaction With Exposure in Adulthood." Synapse (New York, N.Y.), vol. 57, no. 3, 2005, pp. 148-59.
Cohen MA, Skelton MR, Schaefer TL, et al. Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood. Synapse. 2005;57(3):148-59.
Cohen, M. A., Skelton, M. R., Schaefer, T. L., Gudelsky, G. A., Vorhees, C. V., & Williams, M. T. (2005). Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood. Synapse (New York, N.Y.), 57(3), 148-59.
Cohen MA, et al. Learning and Memory After Neonatal Exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in Rats: Interaction With Exposure in Adulthood. Synapse. 2005 Sep 1;57(3):148-59. PubMed PMID: 15945064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood. AU - Cohen,Martha A, AU - Skelton,Matthew R, AU - Schaefer,Tori L, AU - Gudelsky,Gary A, AU - Vorhees,Charles V, AU - Williams,Michael T, PY - 2005/6/10/pubmed PY - 2005/10/28/medline PY - 2005/6/10/entrez SP - 148 EP - 59 JF - Synapse (New York, N.Y.) JO - Synapse VL - 57 IS - 3 N2 - This study determined whether developmental and adult 3,4-methylenedioxymethamphetamine (MDMA) exposures in rats have interactive effects on body temperature, learning, other behaviors, and monoamine concentrations in the hippocampus, prefrontal cortex, and striatum. Learning was assessed in the Cincinnati water maze (CWM), Morris water maze (MWM), and novel object recognition (NOR). On acquisition trials in the MWM, significant differences from developmental MDMA exposure were found on latency, cumulative distance, path length, and angle of first bearing to the goal, but the early and adult MDMA exposure group performed no worse than the developmental-only MDMA group. In the reversal trials, however, an interaction was seen: latency to the goal, cumulative distance, and angle of first bearing were increased in animals treated both developmentally and in adulthood with MDMA compared with those treated only developmentally. Other tests (elevated zero maze, CWM, NOR, and open-field activity) did not show an interaction, nor did hippocampal concentrations of serotonin or dopamine. However, several behavioral tests showed neonatal MDMA effects, including increased errors in the CWM, reduced time spent with a new object in the NOR test, and reduced locomotor activity in the open-field. By contrast, adult MDMA decreased the number of entries into open quadrants of the elevated zero maze. Litter effects were controlled by treating litter as the experimental unit and using mixed models repeated measures analyses. Correlational analyses suggested that the MWM reversal interaction involves multiple monoamine changes. The results indicate that developmental MDMA exposure can interact with adult exposure to interfere with some aspects of learning. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/15945064/Learning_and_memory_after_neonatal_exposure_to_34_methylenedioxymethamphetamine__ecstasy__in_rats:_interaction_with_exposure_in_adulthood_ L2 - https://doi.org/10.1002/syn.20166 DB - PRIME DP - Unbound Medicine ER -